CAS 64987-85-5

Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate

Description:

Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate, with the CAS number 64987-85-5, is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a succinimidyl ester functional group, which is known for its ability to react with amine groups on proteins, facilitating the formation of stable amide bonds. The presence of a maleimide group allows for selective conjugation to thiol groups, making it particularly useful in creating targeted bioconjugates. This compound is typically characterized by its solid state at room temperature and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Its reactivity and specificity make it valuable in various fields, including biochemistry and molecular biology, for applications such as drug delivery, diagnostic assays, and the development of therapeutic agents. Proper handling and storage conditions are essential to maintain its stability and reactivity, as it may be sensitive to moisture and light.

Formula: C₁₆H₁₈N₂O₆

InChI: InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2

InChI key: InChIKey=JJAHTWIKCUJRDK-UHFFFAOYSA-N

SMILES: C(N1C(=O)C=CC1=O)C2CCC(C(ON3C(=O)CCC3=O)=O)CC2

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
• 1-[(4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexyl)methyl]-1H-pyrrole-2,5-dione
• 1H-Pyrrole-2,5-dione, 1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-
• 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexancarboxylate
• 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate
• 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester
• 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester
• Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester
• N-Hydroxysuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
• N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate
• N-Succinimidyl4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• NSC 344483
• Smcc
• Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
• Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
• Succinimidyl 4-[maleimidomethyl]cyclohexan-1-carboxylate

N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate

CAS: 64987-85-5

Formula: C₁₆H₁₈N₂O₆

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 334.33

Ref: 3B-S0853

N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate

CAS: 64987-85-5

Formula: C₁₆H₁₈N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 334.3239

Ref: IN-DA0038KF

SMCC

CAS: 64987-85-5

SMCC

Formula: C₁₆H₁₈N₂O₆

Purity: ≥98%

Molecular weight: 334.32

Ref: 54-BUP16020

Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate

CAS: 64987-85-5

Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate

Formula: C₁₆H₁₈N₂O₆

Purity: By hplc: 99.8% (Typical Value in Batch COA)

Color and Shape: White Solid-Powder

Molecular weight: 334.32392

Ref: 54-BICL206

SMCC

CAS: 64987-85-5

SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.

Formula: C₁₆H₁₈N₂O₆

Purity: 98.96% - 99.53%

Color and Shape: White Solid

Molecular weight: 334.32

Ref: TM-T9116

N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate

Controlled Product

CAS: 64987-85-5

Applications A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab’)2 fragments to ß-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms
References Maham, D.G., et al.: Anal. Biochem., 162, 163 (1987), Yoshitake, S., et al.: Eur. J. Biochem., 101, 395 (1979), Freytag, J.W., et al.: Clin. Chem., 30(9), 1494 (1984), Mahan, D.E., et al.: Anal. Biochem., 162, 163 (1987), Peeters, J.M., et al.: J. Immunol. Meth., 120, 133 (1989),

Formula: C₁₆H₁₈N₂O₆

Color and Shape: Neat

Molecular weight: 334.32

Ref: TR-S690400

N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

CAS: 64987-85-5

N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate is a versatile compound with a wide range of applications. It is commonly used in research settings as a cross-linking agent and can be utilized in the synthesis of various compounds such as ribavirin, farnesene, temozolomide, gliclazide, and more.

Formula: C₁₆H₁₈N₂O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 334.32 g/mol

Ref: 3D-FS27894

2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate

CAS: 64987-85-5

Formula: C₁₆H₁₈N₂O₆

Purity: 95%

Color and Shape: Solid, White powder

Molecular weight: 334.328

Ref: 10-F214622

SMCC

CAS: 64987-85-5

2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate

Formula: C₁₆H₁₈N₂O₆

Purity: 97%

Molecular weight: 334.32

Ref: IN-DG151232

Succinimidyl-4-(N- (N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC), 98%

CAS: 64987-85-5

Formula: C₁₆H₁₈N₂O₆

Purity: min. 98%

Color and Shape: White, Crystalline powder

Molecular weight: 334.32

Ref: SR-24088