CAS 67-30-1

Tetraiodothyroacetic acid

Description:

Tetraiodothyroacetic acid, commonly referred to as Tetrac, is a synthetic derivative of thyroxine (T4) and is characterized by the presence of four iodine atoms attached to its aromatic structure. This compound is known for its role in influencing metabolic processes and has been studied for its potential therapeutic applications, particularly in the context of thyroid hormone regulation. Tetraiodothyroacetic acid exhibits high lipophilicity due to its iodine content, which affects its solubility and bioavailability. It is typically found in a crystalline form and is stable under standard laboratory conditions. The compound interacts with thyroid hormone receptors, influencing gene expression and metabolic pathways. Its pharmacological properties have made it a subject of interest in endocrinology and metabolic research. However, as with many iodine-containing compounds, caution is advised regarding its use, as excessive iodine can lead to thyroid dysfunction. Overall, Tetraiodothyroacetic acid represents a significant compound in the study of thyroid hormones and their analogs.

Formula: C₁₄H₈I₄O₄

InChI: InChI=1/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)

InChI key: InChIKey=PPJYSSNKSXAVDB-UHFFFAOYSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(CC(O)=O)C=C2I

Synonyms:

• 3,3′,5,5′-Tetraiodothyroacetic acid
• 3,5,3′,5′-Tetraiodothyroacetic acid
• 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid
• 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid
• 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid
• Acetic acid, (4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)- (8CI)
• Acetic acid, [4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-
• Acide 3,5,3',5'-tetraiodothyroacetique
• Acide 3,5,3',5'-tetraiodothyroacetique [French]
• Benzeneacetic acid, 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-
• Benzeneacetic acid, 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-
• Tetrac
• Tetraiodothyroacetic acid
• Thyroacetic acid, 3,3',5,5'-tetraiodo-
• Thyroacetic acid, 3,3′,5,5′-tetraiodo-
• 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid, Tetrac
• 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid
• (4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-aceticaci
• 2-[3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
• 3,3’,5,5’-tetraiodo-thyroaceticaci
• tetraiodothyroaceticacid
• 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci
• 3,5,3',5'-Tetraiodothyroacetic acid
• 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
• 3,5-DIIODO-4-(4-HYDROXY-3,5-DIIODOPHENOXY)PHENYLACETIC ACID
• [3,5-Diiodo-4-(3,5-diiodo-4-hydroxyphenoxy)phenyl]acetic acid
• acide3,5,3’,5’-tetraiodothyroacetique

3,3',5,5'-Tetraiodothyroacetic Acid

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Yellow to Green powder to crystal

Molecular weight: 747.83

Ref: 3B-T3730

Tetraiodothyroacetic Acid (2-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)acetic acid)

CAS: 67-30-1

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Formula: C₁₄H₈I₄O₄

Color and Shape: Off-White Powder

Molecular weight: 747.66015

Ref: 45-1A11700

Tetrac

CAS: 67-30-1

Tetrac

Formula: C₁₄H₈I₄O₄

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 747.83

Ref: 54-BUP11003

Liothyronine EP Impurity D (Levothyroxine EP Impurity D, Tetraiodothyroacetic Acid)

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Molecular weight: 747.83

Ref: 4Z-L-242007

[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic Acid (Tetraiodothyroacetic Acid)

Controlled Product

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Color and Shape: Neat

Molecular weight: 747.83

Ref: 86-MM0626.05

Tetrac

CAS: 67-30-1

Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking

Formula: C₁₄H₈I₄O₄

Purity: 99.00%

Color and Shape: White Solid

Molecular weight: 747.83

Ref: TM-T36715

Liothyronine EP Impurity D

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Molecular weight: 747.8

Ref: ST-EA-CP-L45004

Levothyroxine EP Impurity D

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Molecular weight: 747.82

Ref: ST-EA-CP-L18004

3,5,3',5'-Tetraiodo Thyroacetic Acid

Controlled Product

CAS: 67-30-1

Impurity Levothyroxine EP Impurity D / T4-Acetic Acid (USP)
Applications Thyroid hormone analogue. A potent Thyroxine impurity. T4-Acetic Acid (USP).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Horst, C., et al.: Biochem. J., 261, 945 (1989), Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992), Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999), Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002),

Formula: C₁₄H₈I₄O₄

Color and Shape: Neat

Molecular weight: 747.83

Ref: TR-T296125

3,5,3',5'-Tetraiodothyroacetic acid

CAS: 67-30-1

3,5,3',5'-Tetraiodothyroacetic acid (T4) is a thyroid hormone that can be found in the blood and has been shown to have angiogenic properties. T4 has been shown to bind to integrin receptors on endothelial cells and stimulate the proliferation of these cells. This hormone also has pro-apoptotic activity, inducing programmed cell death in cancer cells. T4 is used as a model system for studying the molecular pathogenesis of thyroid cancer. T4 is also able to inhibit DNA polymerase activity, which may be responsible for its ability to inhibit tumor growth.

Formula: C₁₄H₈I₄O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 747.83 g/mol

Ref: 3D-FT28150

Tetrac

CAS: 67-30-1

Purity: 98%

Molecular weight: 747.832

Ref: 10-F987812

Liothyronine EP Impurity D

CAS: 67-30-1

Formula: C₁₄H₈I₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 747.83

Ref: 4Z-T-4212