CAS 67914-60-7

1-Acetyl-4-(4-hydroxyphenyl)piperazine

Description:

1-Acetyl-4-(4-hydroxyphenyl)piperazine, with the CAS number 67914-60-7, is a chemical compound characterized by its piperazine core, which is a six-membered ring containing two nitrogen atoms. This compound features an acetyl group and a para-hydroxyphenyl substituent, contributing to its unique properties. It is typically a white to off-white solid and is soluble in organic solvents, reflecting its moderate polarity. The presence of the hydroxyl group enhances its potential for hydrogen bonding, which can influence its reactivity and interactions with biological systems. This compound may exhibit pharmacological activity, making it of interest in medicinal chemistry, particularly in the development of therapeutic agents. Its structure allows for various modifications, which can lead to derivatives with altered biological activities. As with many piperazine derivatives, it may interact with neurotransmitter systems, suggesting potential applications in treating neurological disorders. However, specific biological activities and safety profiles would require further investigation through empirical studies.

Formula: C₁₂H₁₆N₂O₂

InChI: InChI=1S/C12H16N2O2/c1-10(15)13-6-8-14(9-7-13)11-2-4-12(16)5-3-11/h2-5,16H,6-9H2,1H3

InChI key: InChIKey=AGVNLFCRZULMKK-UHFFFAOYSA-N

SMILES: C(C)(=O)N1CCN(CC1)C2=CC=C(O)C=C2

Synonyms:

• 1-Acetyl-4-(4hydroxyphenyl)piperazine
• 1-Acetyl-4-(p-hydroxyphenyl)piperazine
• 1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone
• 1-[4-(4-Hydroxyphenyl)Piperazin-1-Yl]Ethanone
• 1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethan-1-one
• 4-(1-Acetylpiperazin-4-yl)phenol
• 4-(4-Acetyl-1-piperazino)phenol
• 4-(4-Acetylpiperazin-1-yl)phenol
• 4-(4-Acetylpiperazin-4-Yl)Phenol
• 4-(4-Acetylpiperazino)phenol
• Ethanone, 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-
• Piperazine, 1-acetyl-4-(4-hydroxyphenyl)-
• T 1141

1-Acetyl-4-(4-hydroxyphenyl)piperazine

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Light red powder to crystal

Molecular weight: 220.27

Ref: 3B-A1845

4-(1-Acetylpiperazin-4-yl)phenol

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 220.2676

Ref: IN-DA003JXV

Ketoconazole Impurity 13

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 220.27

Ref: 4Z-K-019

1-Acetyl-4-(4-hydroxyphenyl)piperazine

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Molecular weight: 220.27

Ref: 7W-GK0155

1-[4-(4-Hydroxyphenyl)piperazino]ethan-1-one

CAS: 67914-60-7

1-[4-(4-Hydroxyphenyl)piperazino]ethan-1-one

Purity: 98%

Molecular weight: 220.27g/mol

Ref: 54-OR28969

1-Acetyl-4-(4-hydroxyphenyl)piperazine

Controlled Product

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Color and Shape: Neat

Molecular weight: 220.27

Ref: 86-MM0145.05

1-Acetyl-4-(4-hydroxyphenyl)piperazine

Controlled Product

CAS: 67914-60-7

Applications 1-Acetyl-4-(4-hydroxyphenyl)piperazine is an intermediate used to prepare Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo.
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

Formula: C₁₂H₁₆N₂O₂

Color and Shape: White

Molecular weight: 220.27

Ref: TR-A179045

1-Acetyl-4-(4-hydroxyphenyl)piperazine

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Molecular weight: 220.27

Ref: ST-EA-CP-K2006

1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

CAS: 67914-60-7

Formula: C₁₂H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid, White to pale yellow powder

Molecular weight: 220.272

Ref: 10-F321259

1-Acetyl-4-(4-hydroxyphenyl)piperazine

CAS: 67914-60-7

1-Acetyl-4-(4-hydroxyphenyl)piperazine is a triazole antifungal that inhibits the synthesis and activity of nitric oxide. It binds to the N1 atom of the molecule, which is the site of nitrite ion, and prevents it from reacting with chloride ions. This binding also prevents nucleophilic attack on imine bonds in proteins and DNA. The photophysical properties of 1-acetyl-4-(4-hydroxyphenyl)piperazine are determined by its coumarin derivatives, which absorb light at wavelengths between 400 and 500 nm. The compound has been found to be specific for fungi, but not bacteria or yeast. 1-Acetyl-4-(4-hydroxyphenyl)piperazine has been shown to be effective against Candida albicans and other strains of yeast when used as an oral or topical treatment.

Formula: C₁₂H₁₆N₂O₂

Purity: Min. 95%

Molecular weight: 220.27 g/mol

Ref: 3D-FA17079

1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

CAS: 67914-60-7

1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T67589 and the CAS number is 67914-60-7.

Formula: C₁₂H₁₆N₂O₂

Color and Shape: Solid

Molecular weight: 220.272

Ref: TM-T67589