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Hexamethylphosphoramide

CAS 680-31-9: Hexamethylphosphoramide

Description:Hexamethylphosphoramide (HMPA) is an organophosphorus compound characterized by its chemical formula C6H18N3OP. It is a colorless, odorless liquid that is highly polar and exhibits excellent solubility in water and many organic solvents. HMPA is known for its ability to act as a strong polar aprotic solvent, making it valuable in various chemical reactions, particularly in nucleophilic substitutions and polymer chemistry. Its structure features a phosphorus atom bonded to three methyl groups and a phosphoramidate group, contributing to its unique properties. HMPA is also recognized for its ability to stabilize reactive intermediates, such as carbocations and carbanions, due to its strong hydrogen-bonding capabilities. However, it is important to note that HMPA is considered toxic and poses health risks upon exposure, necessitating careful handling and appropriate safety measures in laboratory settings. Its applications extend to organic synthesis, where it serves as a solvent and reagent, as well as in the production of various chemical compounds.

Formula:C6H18N3OP

InChI:InChI=1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3

InChI key:InChIKey=GNOIPBMMFNIUFM-UHFFFAOYSA-N

SMILES:O=P(N(C)C)(N(C)C)N(C)C

  • Synonyms:
  • Eastman Inhibitor HPT
  • Ent 50,882
  • HPT
  • Hempa
  • Hexametapol
  • Hexamethylorthophosphoric triamide
  • Hexamethylphosphamide
  • Hexamethylphosphoramde (HMPA)
  • Hexamethylphosphoramide
  • Hexamethylphosphoric Triamide
  • See more synonyms
  • Hexamethylphosphoric acid triamide
  • Hexamethylphosphorotriamide
  • Hexamethylphosphorsaeuretriamid
  • Hexamethylphosporic triamide
  • Hexamethyltriamidophosphate
  • Hexametiltriamida Fosforica
  • Hmpa
  • Hmpt
  • Hmpta
  • Light Stabilizer HPT
  • N,N',N''-Hexamethylphosphoramide
  • N,N,N′,N′,N′′,N′′-Hexamethylphosphoric triamide
  • Nsc 113131
  • Nsc 7967
  • Phosphoric acid hexamethyltriamide
  • Phosphoric hexamethyltriamide
  • Phosphoric triamide, N,N,N',N',N'',N''-hexamethyl-
  • Phosphoric tris(dimethylamide)
  • Phosphoryl hexamethyltriamide
  • Triamide hexamethylphosphorique
  • Tris(dimethylamino)phosphine oxide
  • [Bis(dimethylamino)phosphoryl]dimethylamine
  • Hexamethyl Phosphoramide
  • Phosphoric triamide, hexamethyl-
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Hexamethylphosphoramide

CAS:680-31-9

Ref: 10-F075260

1kg77.00 €
25g14.00 €
100g21.00 €
500g48.00 €
Estimated delivery in United States, on Thursday 10 Apr 2025
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Hexamethylphosphoric Triamide

CAS:680-31-9

Ref: 3B-H0095

25g30.00 €
100g71.00 €
500g200.00 €
Estimated delivery in United States, on Thursday 10 Apr 2025
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Hexamethylphosphoramide

CAS:680-31-9

Ref: IN-DA0034ZW

1kg77.00 €
25g25.00 €
5kg192.00 €
100g25.00 €
10kg318.00 €
250g36.00 €
500g52.00 €
Estimated delivery in United States, on Thursday 17 Apr 2025
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Hexamethylphosphamide

Controlled Product
CAS:680-31-9

Ref: 04-C14194700

5ml101.00 €
Estimated delivery in United States, on Tuesday 22 Apr 2025
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Hexamethylphosphoramide

CAS:680-31-9

Ref: 54-OR13709

1kg129.00 €
Estimated delivery in United States, on Thursday 24 Apr 2025
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Hexamethyltriamidophosphate

Controlled Product
CAS:680-31-9

Ref: TR-H294325

5g97.00 €
100g160.00 €
250g351.00 €
Estimated delivery in United States, on Wednesday 28 May 2025
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Hexamethylphosphoramide

Controlled Product
CAS:680-31-9

Ref: 3D-FH04180

1kg663.00 €
2kg1,005.00 €
5kg1,184.00 €
Estimated delivery in United States, on Thursday 12 Jun 2025
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