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CAS 70458-96-7

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norfloxacin

Description:
Norfloxacin is a synthetic fluoroquinolone antibiotic that is primarily used to treat bacterial infections, particularly those affecting the urinary tract and gastrointestinal system. It operates by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair, thereby preventing bacterial growth. Norfloxacin is characterized by its broad-spectrum activity against both Gram-negative and some Gram-positive bacteria. It is typically administered orally and is well-absorbed in the gastrointestinal tract, although its bioavailability can be affected by the presence of divalent and trivalent metal ions, which can form insoluble complexes. The substance is generally considered to have a favorable safety profile, but it may cause side effects such as gastrointestinal disturbances, central nervous system effects, and, in rare cases, tendon damage. Norfloxacin is also subject to resistance, which can limit its effectiveness. As with all antibiotics, it is essential to use norfloxacin judiciously to minimize the development of resistance and preserve its efficacy in treating infections.
Formula:C16H18FN3O3
InChI:InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChI key:InChIKey=OGJPXUAPXNRGGI-UHFFFAOYSA-N
SMILES:C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2)N3CCNCC3
Synonyms:
  • 1,4-Dihydro-1-Ethyl-6-Fluoro-4-Oxo-7-(1-Piperazinyl)-3-Quinolinecarboxylic Acid
  • 1-Ethyl-6-Fluoro-4-Oxo-7-Piperazin-1-Yl-Quinoline-3-Carboxylic Acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
  • 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
  • 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
  • 2-Hydroxypropanoic Acid
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
  • 4803P
  • See more synonyms
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