CAS 70578-24-4

Yunaconitine

Description:

Yunaconitine is a chemical compound classified as an alkaloid, specifically derived from the plant genus Aconitum, commonly known as monkshood. It is known for its complex structure, which includes multiple rings and functional groups characteristic of alkaloids. Yunaconitine exhibits potent pharmacological properties, particularly as a neurotoxin, affecting the nervous system by blocking sodium channels, which can lead to significant physiological effects. This compound has garnered interest in medicinal chemistry for its potential therapeutic applications, although its toxicity limits its use. In terms of solubility, yunaconitine is typically soluble in organic solvents but may have limited solubility in water. Its stability can be influenced by environmental factors such as pH and temperature. Due to its toxic nature, handling yunaconitine requires caution, and it is subject to regulatory scrutiny in many regions. Research continues to explore its mechanisms of action and potential applications in pain management and other medical fields, while also emphasizing the importance of safety and toxicity assessments.

Formula: C₃₅H₄₉NO₁₁

InChI: InChI=1S/C35H49NO11/c1-8-36-16-32(17-41-3)22(38)13-23(43-5)35-21-14-33(40)24(44-6)15-34(47-18(2)37,26(29(35)36)27(45-7)28(32)35)25(21)30(33)46-31(39)19-9-11-20(42-4)12-10-19/h9-12,21-30,38,40H,8,13-17H2,1-7H3/t21-,22-,23+,24+,25-,26+,27+,28-,29-,30-,32+,33+,34-,35+/m1/s1

InChI key: InChIKey=LLEMSCWAKNQHHA-IWXJPZPUSA-N

SMILES: O(C)[C@@H]1[C@@]23[C@]4([C@](COC)(CN(CC)[C@@]2([C@]([C@@H]4OC)([C@]5(OC(C)=O)[C@@]6([C@]3(C[C@@](O)([C@@H]6OC(=O)C7=CC=C(OC)C=C7)[C@@H](OC)C5)[H])[H])[H])[H])[C@H](O)C1)[H]

Synonyms:

• (1alpha,3alpha,6alpha,14alpha,16beta)-8-Acetoxy-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl 4-methoxybenzoate
• 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14-tetrol deriv.
• 3α,13-Dihydroxyforesaconitine
• 8-(Acetyloxy)-20-Ethyl-3,13-Dihydroxy-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitan-14-Yl 4-Methoxybenzoate
• Aconitane-3,8,13,14-tetrol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-(4-methoxybenzoate), (1α,3α,6α,14α,16β)-
• Guayewuanine B
• Isoaconitine
• Vilmorrianine B
• Yunaconitine
• Yunnaconitine

3α,13-Dihydroxyforesaconitine

CAS: 70578-24-4

Formula: C₃₅H₄₉NO₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 659.7637

Ref: IN-DA00FBG2

Yunaconitine

CAS: 70578-24-4

Formula: C₃₅H₄₉NO₁₁

Molecular weight: 659.77

Ref: 7W-GY4091

Yunaconitine

CAS: 70578-24-4

Yunaconitine

Purity: ≥98%

Molecular weight: 659.76g/mol

Ref: 54-BUP04592

Yunaconitine

CAS: 70578-24-4

Formula: C₃₅H₄₉NO₁₁

Purity: 95%~99%

Molecular weight: 659.773

Ref: BP-BP1463

Yunaconitine

CAS: 70578-24-4

Yunaconitine has anti-inflammatory, analgesic effects, reduces fever at 5μg/kg orally, and inhibits granuloma and vascular permeability.

Formula: C₃₅H₄₉NO₁₁

Purity: 98.13% - 98.46%

Color and Shape: Solid

Molecular weight: 659.76

Ref: TM-T5S1889

Yunnaconitine

Controlled Product

CAS: 70578-24-4

Applications Yunnaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes. Yunnaconitine is a deiterpene alkaloid, known to exhibit cytotoxic activity in human leukemic cell. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References He, Y.Q., et al.: J. Pharma. Analysis., 1, 57 (2011); Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010); Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010);

Formula: C₃₅H₄₉NO₁₁

Color and Shape: Neat

Molecular weight: 659.76

Ref: TR-Y100900

Yunaconitine

CAS: 70578-24-4

Yunaconitine is a diterpenoid alkaloid, which is a natural compound derived from Aconitum species, specifically found in plants such as monkshood. This compound affects the functionality of sodium ion channels by prolonging the open state, allowing continuous influx of sodium ions into cells. As a result, it can significantly alter cellular excitability and conductivity.

Formula: C₃₅H₄₉NO₁₁

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 659.76 g/mol

Ref: 3D-FY65733