CAS 72509-76-3

Felodipine

Description:

Felodipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by selectively inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle during depolarization, leading to vasodilation and reduced blood pressure. Felodipine is characterized by its lipophilic nature, which enhances its absorption and bioavailability. The compound typically appears as a yellow crystalline solid and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics are influenced by factors such as food intake, which can affect its absorption. Felodipine is metabolized in the liver, primarily by cytochrome P450 enzymes, and its metabolites are excreted mainly through urine. Common side effects may include peripheral edema, headache, and flushing. Due to its mechanism of action, felodipine is effective in managing cardiovascular conditions, but it should be used with caution in patients with certain pre-existing conditions or those taking specific medications that may interact with its metabolism.

Formula: C₁₈H₁₉Cl₂NO₄

InChI: InChI=1/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key: InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(Cl)C(Cl)=CC=C2

Synonyms:

• H 154/82
• Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Felodipine
• Plendil
• 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
• 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
• ,ethylmethylester
• Felodipin
• Agon
• 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
• FelodipineUsp25DmfGmp
• dl-Felodipine
• h154/82
• Hydac
• (RS)-Felodipine
• Splendil
• modip
• ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
• FEXOFENADINE HCL

Felodipine

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light orange to Pale yellow green powder to crystal

Molecular weight: 384.25

Ref: 3B-F0814

Felodipine

CAS: 72509-76-3

A dihydropyridine calcium channel blocker

Formula: C₁₈H₁₉Cl₂NO₄

Color and Shape: Powder or crystals or crystalline powder, Yellow to yellow-green

Molecular weight: 384.25

Ref: 02-J61195

Felodipine

CAS: 72509-76-3

Color and Shape: Neat

Ref: 61-FOR0139.00

Felodipine impurity standard

CAS: 72509-76-3

Felodipine impurity standard

Color and Shape: Off White Solid

Ref: 47-758

Felodipine

CAS: 72509-76-3

Felodipine

Formula: C₁₈H₁₉Cl₂NO₄

Purity: 99.8%

Color and Shape: Off White

Molecular weight: 383.06911

Ref: 47-777

FELODIPINE CRS

CAS: 72509-76-3

FELODIPINE CRS

Ref: 41-F0030000

Felodipine

CAS: 72509-76-3

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₈H₁₉Cl₂NO₄

Color and Shape: White Yellow Powder

Molecular weight: 383.06911

Ref: 45-1269389

Felodipine

CAS: 72509-76-3

Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.

Formula: C₁₈H₁₉Cl₂NO₄

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 384.25

Ref: TM-T0145

Felodipine

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 384.2538

Ref: IN-DA005SL4

3-Ethyl 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate

CAS: 72509-76-3

3-Ethyl 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate

Purity: 99%

Molecular weight: 384.25g/mol

Ref: 54-OR1010981

Felodipine

CAS: 72509-76-3

Felodipine

Purity: ≥98%

Molecular weight: 384.25g/mol

Ref: 54-BUP15014

Felodipine

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Color and Shape: Pale Green Solid

Molecular weight: 384.25

Ref: 4Z-F-132

Felodipine

CAS: 72509-76-3

Felodipine

Purity: 99%

Molecular weight: 384.25g/mol

Ref: 54-OR1025140

Felodipine

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White or light-yellow crystalline powder

Molecular weight: 384.25

Ref: 7W-GP8252

Felodipine-d3 (2,3-dichlorophenyl-d3)

CAS: 1219795-30-8, 72509-76-3

Purity: 99 atom % D

Color and Shape: Yellow Solid

Molecular weight: 387.28

Ref: 3U-D7175

Felodipine 100 µg/mL in Acetonitrile

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Color and Shape: Single Solution

Molecular weight: 384.25

Ref: 04-A13407800AL-100

Felodipine

CAS: 72509-76-3

Formula: C₁₈H₁₉Cl₂NO₄

Color and Shape: Neat

Molecular weight: 384.25

Ref: 04-C13407800

Felodipine

CAS: 72509-76-3

Color and Shape: Neat

Ref: 86-MM0139.00

Felodipine-13C4-d3

CAS: 72509-76-3

Formula: C₁₈H₁₆Cl₂NO₄D₃

Molecular weight: 391.24

Ref: 4Z-F-135

Felodipine-13C4, d3

Controlled Product

CAS: 72509-76-3

Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.
References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)

Formula: C₁₄₁₃C₄H₁₆D₃Cl₂NO₄

Color and Shape: Neat

Molecular weight: 391.24

Ref: TR-F232376