CAS 789-61-7

2′-Deoxy-6-thioguanosine

Description:

2′-Deoxy-6-thioguanosine is a nucleoside analog that features a thiol group at the 6-position of the guanine base, replacing the typical oxygen found in standard nucleosides. This modification imparts unique biochemical properties, making it of interest in various fields, including medicinal chemistry and molecular biology. The compound consists of a deoxyribose sugar linked to a modified guanine base, which can participate in nucleic acid synthesis and potentially interfere with normal cellular processes. Its structure allows it to be incorporated into DNA, where it may affect replication and transcription. 2′-Deoxy-6-thioguanosine has been studied for its potential therapeutic applications, particularly in the context of antiviral and anticancer treatments, as it can mimic natural nucleosides and disrupt the function of nucleic acids in pathogens or cancer cells. Additionally, its unique thiol group can participate in redox reactions, influencing cellular signaling pathways. Overall, this compound represents a significant area of research due to its potential to modulate biological systems.

Formula: C₁₀H₁₃N₅O₃S

InChI: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1

InChI key: InChIKey=SCVJRXQHFJXZFZ-KVQBGUIXSA-N

SMILES: S=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Synonyms:

• 2′-Deoxythioguanosine
• Thioguanine deoxyriboside
• Guanosine, 2′-deoxy-6-thio-
• 2′-Deoxy-6-thioguanosine
• 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

Formula: C₁₀H₁₃N₅O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 283.3069

Ref: IN-DA00G38M

2''-Deoxy-6-thioguanosine

CAS: 789-61-7

Ref: 7W-GN2065

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine

Purity: ≥95%

Molecular weight: 283.31g/mol

Ref: 54-BUP06562

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.

Formula: C₁₀H₁₃N₅O₃S

Purity: 97.52%

Color and Shape: Solid

Molecular weight: 283.31

Ref: TM-T6746

2′-Deoxy-6-Thio-Guanosine

CAS: 789-61-7

Formula: C₁₀H₁₃N₅O₃S

Molecular weight: 283.31

Ref: 4Z-G-2462

2'-Deoxy-6-thio Guanosine

Controlled Product

CAS: 789-61-7

Applications Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);

Formula: C₁₀H₁₃N₅O₃S

Color and Shape: Neat

Molecular weight: 283.31

Ref: TR-D281650

2'-Deoxy-6-thioguanosine

CAS: 789-61-7

2'-Deoxy-6-thioguanosine is a purine nucleoside analog that inhibits the activation of transcription factors such as nuclear factor kappa-B (NF-κB) and activator protein 1 (AP-1). It also inhibits the synthesis of proinflammatory cytokines, such as IL-1β, IL-6, and TNFα. The matrix effect is an important factor in the prevention of tumor progression. 2'-Deoxy-6-thioguanosine has been shown to inhibit cell proliferation and induce apoptosis in squamous cell carcinoma cells by modulating the expression of HLA class II molecules on tumors. It also prevents invasion by blocking matrix metalloproteinase activity. 2'-Deoxy-6-thioguanosine has been found to be effective against bowel diseases such as ulcerative colitis and Crohn's disease, as well as infectious diseases such as HIV/AIDS.

Formula: C₁₀H₁₃N₅O₃S

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 283.31 g/mol

Ref: 3D-ND08563

2'-Deoxy-6-thioguanosine - Bio-X ™

CAS: 789-61-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₃N₅O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 283.31 g/mol

Ref: 3D-BD300155

6-Thio-2′-deoxyguanosine

CAS: 789-61-7

Purity: 98%

Molecular weight: 283.310

Ref: 10-F980551

2'-Deoxy-6-thio Guanosine-13C, 15N2

Controlled Product

CAS: 789-61-7

Applications 2'-Deoxy-6-thio Guanosine-13C, 15N2 is labelled 2'-Deoxy-6-thio Guanosine (D281650) which is a Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999)

Formula: CC₉H₁₃₁₅N₂N₃O₃S

Color and Shape: Neat

Molecular weight: 286.286

Ref: TR-D281652