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CAS 79660-72-3

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Fleroxacin

Description:
Fleroxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those caused by Gram-negative and some Gram-positive organisms. The compound works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription, thereby preventing bacterial cell division and growth. Fleroxacin is typically administered orally and is known for its favorable pharmacokinetic properties, including good absorption and tissue penetration. Its chemical structure includes a bicyclic core with a fluorine atom, which enhances its potency and spectrum of activity compared to earlier generations of quinolones. However, like other fluoroquinolones, it may be associated with side effects such as gastrointestinal disturbances, central nervous system effects, and potential tendon damage. Caution is advised in its use, particularly in certain populations, including those with a history of tendon disorders or in pediatric patients. Overall, Fleroxacin represents an important option in the arsenal of antibiotics for treating resistant bacterial infections.
Formula:C17H18F3N3O3
InChI:InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChI key:InChIKey=XBJBPGROQZJDOJ-UHFFFAOYSA-N
SMILES:C(CF)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2F)N3CCN(C)CC3
Synonyms:
  • 3-Quinolinecarboxylic acid, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
  • 6,8-Difluoro-1-(2-Fluoroethyl)-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid
  • 6,8-Difluoro-1-(2-Fluoroethyl)-1,4-Dihydro-7-(4-Methylpiperazino)-4-Oxo-3-Quinolinecarboxylic Acid
  • 6,8-Difluoro-1-(2-Fluoroethyl)-7-(4-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
  • Am 833
  • Flerofloxacin
  • Megalocin
  • Megalone
  • Quinodis
  • Ro 23-6240
  • See more synonyms
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Found 15 products.