CAS 80-08-0
:Dapsone
Description:
Dapsone, with the CAS number 80-08-0, is an aromatic sulfonamide antibiotic primarily used in the treatment of leprosy and certain types of dermatitis, such as dermatitis herpetiformis. It is a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Dapsone functions by inhibiting bacterial folate synthesis, thereby exerting its antimicrobial effects. Its chemical formula is C12H12N2O2S, and it has a molecular weight of approximately 240.3 g/mol. Dapsone is known for its anti-inflammatory properties, making it effective in treating autoimmune skin conditions. While generally well-tolerated, it can cause side effects such as hemolytic anemia, especially in individuals with glucose-6-phosphate dehydrogenase deficiency. Monitoring of blood parameters is recommended during treatment. Dapsone is often used in combination with other medications to enhance therapeutic efficacy and reduce the risk of resistance.
Formula:C12H12N2O2S
InChI:InChI=1/C12H10O2S.C7H6N2O5/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12;1-4-2-5(8(11)12)3-6(7(4)10)9(13)14/h1-10H;2-3,10H,1H3
InChI key:InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=CC=C(N)C=C1)C2=CC=C(N)C=C2
Synonyms:- 1,1'-Sulfonylbis[4-aminobenzene]
- 1358F
- 4,4'-Dapsone
- 4,4'-Dds
- 4,4'-Diamino Diphenyl Sulfone
- 4,4'-Diamino Diphenyl Sulphone
- 4,4'-Diaminodiphenylsulfon
- 4,4'-Diaminodiphenylsulfone
- 4,4'-Sulfonylbisaniline
- 4,4'-Sulfonylbisbenzamine
- 4,4'-Sulfonyldiphenylamine
- 4,4-Diaminodiphenyl sulfone
- 4,4-Diaminodiphenyl sulphone
- 4,4-Sulfonyldianiline
- 4,4-Sulphonyldianiline
- 4,4′-Diaminobiphenyl sulfone
- 4,4′-Sulfonylbis[benzenamine]
- 4-((4-Aminophenyl)Sulfonyl)Phenylamine
- 4-(4-Aminophenyl)sulfonylaniline
- 4-(4-Aminophenylsulfonyl)benzenamine
- 4-Aminophenyl sulphone
- 44Dds
- Aczone
- Aniline, 4,4'-sulfonyldi-
- Aradur 9664-1
- Aradur 9664-1NL
- Aradur 976
- Aradur 976-1
- Aradur 9761-1
- Araldite HT 976
- Atrisone
- Avlosulfon
- Avlosulfone
- Avlosulphone
- Benzenamine, 4,4'-sulfonylbis-
- Bis(4-aminophenyl) sulfone
- Bis(P-Aminophenyl)Sulfone
- Croysulfone
- Croysulphone
- D 0089
- DDS
- DDS (pharmaceutical)
- DSS
- Dadfs
- Dadps
- Dapson
- Dapsone
- Di(4-Aminophenyl) Sulphone
- Di(4-aminophenyl)sulfone
- Di(p-aminophenyl) sulfone
- Diaminodiphenylsulfone
- Diaphenylsulfon
- Diaphenylsulfone
- Diphenasone
- Diphenyl Sulfone, 4,4'-Diamino-
- Diphone
- Disulone
- Dumitone
- Eporal
- F 1358
- Hardener HT 976
- Hb-Mc-Ge 40
- Hb-Mc-Ge 45
- Hew 62
- Ht 9664
- Ht 976
- Ht 976-1
- Hy 976
- Lapox K 10
- Metabolite C
- Novophone
- Nsc 6091
- P,P'-Sulfonyldianiline
- P-Aminophenyl Sulfone
- Seikacure S
- Servidapson
- Sulfona
- Sulfona-Mae
- Sulphadione
- Sumicure S
- Timtec-Bb Sbb003168
- Udolac
- p,p'-Diaminodiphenyl sulfone
- 4,4'-SULFONYLBISBENZENEAMINE
- Dapsonum
- 4,4-DIAMINODIPHENYLSULPHONE
- 4-AMINOPHENYL SULONE
- See more synonyms
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4,4'-Diaminodiphenyl sulfone, 98%
CAS:<p>It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the</p>Formula:C12H12N2O2SPurity:98%Color and Shape:White to pale cream, PowderMolecular weight:248.30Dapsone
CAS:<p>Other aromatic organo-sulfur compounds (excluding pesticides)</p>Formula:C12H12N2O2SColor and Shape:White Off-White Light Yellow Crystalline PowderMolecular weight:248.061954,4'-Sulfonyldianiline
CAS:Formula:C12H12N2O2SPurity:98%Color and Shape:SolidMolecular weight:248.3009Dapsone
CAS:<p>Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.</p>Formula:C12H12N2O2SPurity:99.84%Color and Shape:White To Creamy Solid CrystallineMolecular weight:248.30Bis(4-aminophenyl) Sulfone
CAS:<p>Bis(4-aminophenyl) Sulfone</p>Formula:C12H12N2O2SPurity:99%Color and Shape: off-white solidMolecular weight:248.30g/molDapsone
CAS:Formula:C12H12N2O2SPurity:(Titration) 98.0 - 102.0 %Color and Shape:White to off-white crystalline powderMolecular weight:248.30Smart Solutions™ v59 PharmaVetResiMix Kit 1
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Color and Shape:MixtureDapson 100 µg/mL in Methanol
CAS:Controlled ProductFormula:C12H12N2O2SColor and Shape:Single SolutionMolecular weight:248.30Bis(4-aminophenyl) Sulfone
CAS:Formula:C12H12N2O2SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:248.30Dapsone
CAS:Controlled Product<p>Applications An antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>Formula:C12H12N2O2SColor and Shape:NeatMolecular weight:248.30Dapsone
CAS:<p>Dapsone is a nonsteroidal anti-inflammatory drug that is used to treat various types of infectious diseases and skin disorders. It acts by blocking the synthesis of dihydrofolic acid, which leads to inhibition of bacterial growth. Dapsone inhibits the activity of monoethyl ether reductase (NADH) in human polymorphonuclear leukocytes, which slows the production of hydrogen peroxide and prevents oxidative damage to cellular components. It has been shown to be effective against both erythema multiforme and chronic dermatitis herpetiformis with minimal side effects. The use of dapsone may be helpful in diagnosis as it can inhibit polymerase chain reactions that are specific for squamous cells. There are also reports that dapsone may affect intestinal motility and cause bowel disease.</p>Formula:C12H12N2O2SPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:248.3 g/mol
