CAS 84449-90-1

Raloxifene

Description:

Raloxifene is a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of osteoporosis in postmenopausal women and for reducing the risk of invasive breast cancer. Its chemical formula is C28H27NO4S, and it features a sulfonamide group, which contributes to its biological activity. Raloxifene exhibits estrogenic effects on bone tissue, promoting bone density while antagonizing estrogen receptors in breast and uterine tissues, thereby reducing the risk of estrogen-dependent cancers. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Raloxifene is well-absorbed in the gastrointestinal tract, but its bioavailability is affected by first-pass metabolism. Common side effects may include hot flashes, leg cramps, and an increased risk of thromboembolic events. As a non-steroidal compound, Raloxifene's mechanism of action involves binding to estrogen receptors and modulating gene expression, making it a valuable therapeutic option in women's health.

Formula: C₂₈H₂₇NO₄S

InChI: InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2

InChI key: InChIKey=GZUITABIAKMVPG-UHFFFAOYSA-N

SMILES: C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(OCCN5CCCCC5)C=C4

Synonyms:

• [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
• Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
• Raloxifene
• Keoxifene
• LY 139481

Raloxifene Hydrochloride

CAS: 82640-04-8, 84449-90-1

Formula: C₂₈H₂₇NO₄S·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow to Green powder to crystal

Molecular weight: 510.05

Ref: 3B-R0109

Raloxifene

Controlled Product

CAS: 84449-90-1

Formula: C₂₈H₂₇NO₄S

Color and Shape: Neat

Molecular weight: 473.58

Ref: 04-C16806200

Raloxifene

CAS: 84449-90-1

Raloxifene (LY139481) is an estrogen receptor modulator exhibiting estrogen agonist and antagonist activity at different sites, with antiviral activity.

Formula: C₂₈H₂₇NO₄S

Purity: 99.39%

Color and Shape: Light-Yellow Solid

Molecular weight: 473.58

Ref: TM-T20419

Raloxifene

Controlled Product

CAS: 84449-90-1

Applications Raloxifene is a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984); Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998)

Formula: C₂₈H₂₇NO₄S

Color and Shape: Off White Solid

Molecular weight: 473.58

Ref: TR-R099995

Raloxifene

Controlled Product

CAS: 84449-90-1

Raloxifene is a non-steroidal drug that binds to estrogen receptors, which may be useful in the treatment of postmenopausal osteoporosis. Raloxifene has been shown to increase bone mineral density and reduce the risk of vertebral fractures in postmenopausal women with osteoporosis. Raloxifene also has been found to decrease breast cancer risk by about 50% in postmenopausal women. The drug binds to estrogen receptors in breast tissue, preventing the stimulation of these cells by estrogen and decreasing their growth rate. Raloxifene also inhibits the production of lactogenic hormones such as prolactin and progesterone that are involved in breast cancer development. Raloxifene hydrochloride is used at doses between 60 mg and 120 mg per day for a duration of 5 years.
Raloxifene hydrochloride is not active against estrogen receptor positive tumors and should not be used for treatment of breast cancer.

Formula: C₂₈H₂₇NO₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 473.58 g/mol

Ref: 3D-FR175031

2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol

CAS: 84449-90-1

Formula: C₂₈H₂₇NO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 473.5833

Ref: IN-DA01A7CU