CAS 86386-73-4

Fluconazole

Description:

Fluconazole is an antifungal medication primarily used to treat fungal infections, particularly those caused by Candida species and Cryptococcus neoformans. It belongs to the triazole class of antifungals and works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Fluconazole is characterized by its high oral bioavailability, allowing for effective systemic treatment, and it is often administered in both oral and intravenous forms. The substance is generally well-tolerated, with common side effects including gastrointestinal disturbances and headache. It has a relatively long half-life, enabling once-daily dosing for many indications. Fluconazole is also notable for its ability to penetrate various body tissues, including the central nervous system, making it effective for treating meningitis. However, it can interact with other medications due to its effects on liver enzymes, necessitating careful monitoring in patients on multiple therapies. Overall, fluconazole is a critical agent in the management of systemic and superficial fungal infections.

Formula: C₁₃H₁₂F₂N₆O

InChI: InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

InChI key: InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N

SMILES: C(CN1C=NC=N1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

Synonyms:

• 1-(2,4-Difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl]methanol
• 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-
• 2-(2,4-Difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol
• 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Alkanazole
• Biozolene
• Diflucan
• Difluconazole
• Elazor
• Floroxan
• Flucan
• Fluconal
• Flucostat
• Flumycon
• Flunazol
• Flusol
• Flutec
• Fluzon
• Fungican
• Fungicon
• Triconal
• Triflucan
• Uk 49858
• Zocon
• Zoltec
• a.-(2,4-Difluorophenyl)-a-(1H-1,2,4,-triazol-1-ylmethyl)-1H-1,2 ,4-triazole-1-ethanol
• α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol

Fluconazole

CAS: 86386-73-4

Fluconazole is an antifungal drug used to treat a wide range of fungal infections. Fluconazole is a cytochrome demethylase system inhibitor that acts by interfering with β-glucan biosynthesis. It has been shown to be effective in treating candidemia, a life-threatening form of candidiasis caused by the fungus Candida albicans. Fluconazole seems to be more effective than amphotericin B in treating some isolates of C. albicans, making it a valuable tool in the fight against this deadly fungal infection, although due to the increase of antimicrobial resistance, fluconazole has been studied in combination with other drugs (e.g. farnesol).

Formula: C₁₃H₁₂F₂N₆O

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 306.27 g/mol

Ref: 3D-FD23320

Fluconazole (FLC), 98%

CAS: 86386-73-4

Formula: C₁₃H₁₂F₂N₆O

Purity: min. 98%

Color and Shape: White to almost white, Hygroscopic powder

Molecular weight: 306.27

Ref: SR-22239

2,4-Difluoro-α,α-1-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol

CAS: 86386-73-4

Formula: C₁₃H₁₂F₂N₆O

Purity: 98%

Color and Shape: Solid, White to very pale yellow powder

Molecular weight: 306.277

Ref: 10-F036566

Fluconazole

CAS: 86386-73-4

Color and Shape: Neat

Ref: 61-FOR0235.00