CAS 879085-55-9

Vismodegib

Description:

Vismodegib is a small molecule inhibitor that targets the Hedgehog signaling pathway, specifically designed to treat certain types of cancer, particularly basal cell carcinoma. It is classified as a hedgehog pathway inhibitor and works by blocking the activity of Smoothened, a protein involved in the pathway, thereby preventing the proliferation of cancer cells. Vismodegib is typically administered orally and is known for its role in treating advanced basal cell carcinoma that has metastasized or is locally advanced and cannot be surgically removed. The compound has a molecular formula that reflects its complex structure, which includes multiple functional groups contributing to its pharmacological activity. Common side effects associated with Vismodegib include muscle spasms, hair loss, and gastrointestinal disturbances. Due to its mechanism of action, it is also being studied for potential use in other malignancies associated with aberrant Hedgehog signaling. As with any medication, its use should be closely monitored by healthcare professionals to manage any adverse effects and ensure therapeutic efficacy.

Formula: C₁₉H₁₄Cl₂N₂O₃S

InChI: InChI=1/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)

InChI key: InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N

SMILES: ClC=1C(=CC(NC(=O)C2=C(Cl)C=C(S(C)(=O)=O)C=C2)=CC1)C3=CC=CC=N3

Synonyms:

• 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
• Benzamide, 2-Chloro-N-[4-Chloro-3-(2-Pyridinyl)Phenyl]-4-(Methylsulfonyl)-
• Erivedge
• Gdc-0449
• Vismodegib
• Vismodegib (GDC-0449)
• Vismodegib 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
• Vismodegib, 98%, a Hedgehog inhibitor
• 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide Vismodegib(GDC0449)
• Vismodegib, >=99%
• GDC-0449,Vismodegib
• 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide

Vismodegib

CAS: 879085-55-9

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₉H₁₄Cl₂N₂O₃S

Color and Shape: White Off-White Powder

Molecular weight: 420.01022

Ref: 45-1715050

Vismodegib

CAS: 879085-55-9

Vismodegib

Purity: ≥98%

Molecular weight: 421.3g/mol

Ref: 54-BUP16978

Vismodegib

CAS: 879085-55-9

Formula: C₁₉H₁₄Cl₂N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 421.29

Ref: 4Z-V-055001

Vismodegib

CAS: 879085-55-9

Vismodegib

Formula: C₁₉H₁₄Cl₂N₂O₃S

Purity: 99.41% (Typical Value in Batch COA)

Color and Shape: off-white solid

Molecular weight: 421.30g/mol

Ref: 54-BISN0157

Vismodegib

CAS: 879085-55-9

Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

Formula: C₁₉H₁₄Cl₂N₂O₃S

Purity: 98% - 99.82%

Color and Shape: Solid

Molecular weight: 421.3

Ref: TM-T2590

Vismodegib

Controlled Product

CAS: 879085-55-9

Applications Vismodegib targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers. Potent Hedgehog inhibitor.
References Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)

Formula: C₁₉H₁₄Cl₂N₂O₃S

Color and Shape: Off-White

Molecular weight: 421.30

Ref: TR-V674700

Vismodegib

CAS: 879085-55-9

Vismodegib is a Hedgehog (Hh) pathway inhibitor belonging to the 2-arylpyridine class. It acts as a competitive antagonist of the smoothened receptor (SMO) localized in the cell membrane. SMO activates an intracellular cascade that results in activation and nuclear translocation of Gli family transcription factor. Vismodegib has been used in clinical trials for treatment of advanced cancers.

Formula: C₁₉H₁₄Cl₂N₂O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 421.30 g/mol

Ref: 3D-FC28712

Vismodegib-d7

Controlled Product

CAS: 879085-55-9

Formula: C₁₉D₇H₇Cl₂N₂O₃S

Color and Shape: Neat

Molecular weight: 428.34

Ref: TR-V674703