CAS 89-25-8

Edaravone

Description:

Edaravone, with the CAS number 89-25-8, is a synthetic compound primarily recognized for its neuroprotective properties. It is classified as a free radical scavenger, which means it can neutralize harmful free radicals in the body, thereby reducing oxidative stress. This characteristic makes it particularly relevant in the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and acute ischemic stroke. Edaravone is typically presented as a colorless to pale yellow liquid and is soluble in water, which facilitates its administration in clinical settings. The compound has a relatively low molecular weight and exhibits a moderate level of lipophilicity, allowing it to penetrate biological membranes effectively. Its mechanism of action involves the inhibition of lipid peroxidation and the protection of neuronal cells from oxidative damage. Edaravone has been studied extensively for its therapeutic potential, and while it is generally well-tolerated, it may have side effects that require monitoring during treatment.

Formula: C₁₀H₁₀N₂O

InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI key: InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

SMILES: O=C1N(N=C(C)C1)C2=CC=CC=C2

Synonyms:

• 1,3,5-Pmp
• 1-Fenil-3-Metil-5-Pirazolona
• 1-Phenyl-3-Methyl-5-Prazalone
• 1-Phenyl-3-Methyl-5-Pyrazole
• 1-Phenyl-3-Methyl-5-Pyrazolone
• 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
• 1-Phenyl-3-methyl-2-pyrazolin-5-one
• 1-Phenyl-3-methyl-5-oxopyrazole
• 1-Phenyl-3-methyl-5-pyrazolinone
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-On
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-One
• 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazole-3-one
• 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
• 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
• 3-Methyl-1-phenyl-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-2-pyrazoline-5-one
• 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one
• 3-Methyl-1-phenyl-5-pyrazolon
• 3-Methyl-1-phenyl-5-pyrazolone
• 3-Methyl-1-phenylpyrazol-5(4H)-one
• 3-Methyl-1-phenylpyrazol-5-one
• 3-Methyl-1-phenylpyrazole-5-one
• 3-Methyl-1-phenylpyrazolin-5-one
• 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
• 4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one
• 5-Methyl-2-phenylpyrazol-3-one
• Developer Z
• Edarabone
• Edaravon
• Edaravone
• Edvaradone
• Mci-186
• Methylphenylpyrazolone
• Nci-C 03952
• Norantipyrine
• Norphenazone
• Nsc 12
• Nsc 26139
• Nsc 2629
• PMP
• Phenylmethyl pyrazolone
• Pyrazolin(2)-5-One, 3-Methyl-1-Phenyl-
• Radicava
• Radicut
• C.I. Developer 1

3-Methyl-1-phenyl-5-pyrazolone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 174.20

Ref: 3B-M0687

3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%

CAS: 89-25-8

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original A

Formula: C₁₀H₁₀N₂O

Purity: 98+%

Color and Shape: Pale cream to cream to yellow to pale brown, Powder

Molecular weight: 174.20

Ref: 02-A11161

PHENAZONE IMPURITY A CRS

CAS: 89-25-8

PHENAZONE IMPURITY A CRS

Ref: 41-Y0001138

Antipyrine Related Compound A (3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one)

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formula: C₁₀H₁₀N₂O

Color and Shape: White Pale Yellow Powder

Molecular weight: 174.07931

Ref: 45-1040016

Edaravone

CAS: 89-25-8

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Formula: C₁₀H₁₀N₂O

Purity: 99.44% - >99.99%

Color and Shape: Pale Yellow Solid Solid Particulate/Powder

Molecular weight: 174.20

Ref: TM-T0407

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 174.1992

Ref: IN-DA0087X2

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 174.20

Ref: 4Z-E-531

Edaravone

CAS: 89-25-8

Edaravone

Purity: ≥98%

Molecular weight: 174.2g/mol

Ref: 54-BUP18301

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

1-Phenyl-3-methyl-5-pyrazolone

Formula: C₁₀H₁₀N₂O

Purity: 98%

Color and Shape: yellow crystalline powder

Molecular weight: 174.20g/mol

Ref: 54-BIP1205

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purity: ≥ 98.0%

Color and Shape: White to yellow to brown powder or crystals

Molecular weight: 174.20

Ref: 7W-GK3502

5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone)

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Color and Shape: Neat

Molecular weight: 174.20

Ref: 86-MM0036.01

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Color and Shape: Neat

Molecular weight: 174.20

Ref: 04-C13105000

3-​Methyl-​1-​phenyl-​2-​pyrazolin-​5-​one(Edaravone)

Controlled Product

CAS: 89-25-8

Impurity Phenazone EP Impurity A
Applications Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
References Reeta KH et al. Eur J Neurosci. 2017 Feb 15Masuda T et al. Oxid Med Cell Longev. 2017;2017:9208489Zhang DY et al. J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):51-56Criswell LA et al. Am J Med. 2002 Apr 15;112(6):465-71.

Formula: C₁₀H₁₀N₂O

Color and Shape: Neat

Molecular weight: 174.20

Ref: TR-E335000

Antipyrine USP Related Compound A

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Molecular weight: 174.2

Ref: ST-EA-CP-A104005

3-Methyl-1-phenyl-2-pyrazoline-5-one

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 174.203

Ref: 10-F038216

Edaravone

CAS: 89-25-8

Edaravone is a drug that belongs to the class of radical scavengers and has been shown to be effective in reducing neuronal death by blocking the mitochondrial permeability transition pore. It also protects against oxidative injury by inhibiting lipid peroxidation, protein nitration, and DNA damage. Edaravone has been shown to be effective in treating bowel disease and possibly other inflammatory diseases such as sepsis. Edaravone is injected intravenously and can be used as an injection solution with dextran sulfate due to its low solubility in water. Edaravone binds reversibly to the toll-like receptor 4 (TLR4) and inhibits TLR4-mediated signaling pathways, which may lead to a reduction of inflammation.

Formula: C₁₀H₁₀N₂O

Purity: Min. 98%

Color and Shape: Powder

Molecular weight: 174.2 g/mol

Ref: 3D-FE22642

Edaravone

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formula: C₁₀H₁₀N₂O

Molecular weight: 174.07931

Ref: 45-1231900