CAS 9002-96-4

α-Tocopheryl polyethylene glycol succinate

Description:

α-Tocopheryl polyethylene glycol succinate, commonly known as TPGS, is a synthetic derivative of vitamin E (α-tocopherol) that is widely used in pharmaceutical and cosmetic formulations. It is characterized by its amphiphilic nature, which allows it to function as a surfactant and solubilizer, enhancing the bioavailability of poorly soluble drugs. TPGS is known for its ability to improve the stability of formulations and can also act as an antioxidant due to the presence of the tocopherol moiety. Its polyethylene glycol (PEG) component contributes to its hydrophilicity, facilitating the formation of micelles and enhancing drug delivery systems. Additionally, TPGS is recognized for its biocompatibility and low toxicity, making it suitable for various applications, including oral, parenteral, and topical drug delivery. Its unique properties enable it to be utilized in a range of industries, from pharmaceuticals to cosmetics, where it can improve product performance and efficacy.

Formula: (C₂H₄O)nC₃₃H₅₄O₅

InChI: InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

InChI key: InChIKey=AOBORMOPSGHCAX-UHFFFAOYSA-N

SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(c(C)c(C)c2O1)OC(=O)CCC(=O)OCCO

Synonyms:

• 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl butanedioate
• <span class="text-smallcaps">D</span>-α-Tocopherol acid polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopherol polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopheryl polyethylene glycol succinate
• Eastman Vitamin ETPGS
• Ethoxylated vitamin E succinate
• Kolliphor TPGS
• Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] succinate, polyoxyethylene ether
• Poly(oxy-1,2-ethanediyl), α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-
• Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-, [2R-[2R*(4R*,8R*)]]-
• Polyethylene glycol vitamin E succinate
• Speziol TPGS Pharma
• Tocophersolan
• Tpgs 1000
• Tpgs 1500
• Tpgs 400-1000
• Tpgs-Ve
• Ve-Tpgs 1000
• Vedrop
• VitE-TPGS
• Vitamin E-TPGS
• d-α-Tocopheryl poly(ethylene glycol) 1000 succinate
• d-α-Tocopheryl polyethylene glycol succinate
• α-Tocopherol polyethylene glycol succinate
• α-Tocopheryl polyethylene glycol succinate
• D-α-Tocopherol polyethylene glycol 1000 succinate

D-α-Tocopherol polyethylene glycol 1000 succinate, USP/NF grade

CAS: 9002-96-4

Color and Shape: White to light-brown powder or waxy solid

Ref: 7W-GK2110

D-α-Tocopherol polyethylene glycol succinate

CAS: 9002-96-4

Purity: ≥ 25.0% (D-Alpha Tocopherol)

Color and Shape: White to light-brown powder or waxy solid

Molecular weight: -

Ref: 7W-GK2339

α-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Color and Shape: White or Colorless to Yellow powder to lump to clear liquid

Ref: 3B-T3118

Tocofersolan

CAS: 9002-96-4

Tocofersolan (TPGS) treats vitamin E deficiency in pediatric digestive malabsorption.

Formula: C₃₉H₆₆O₈

Purity: ≥98%

Color and Shape: Clear Colorless Solid

Molecular weight: 662.94

Ref: TM-T4994

Tocofersolan

CAS: 9002-96-4

Applications Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
References Socha, P. et al.: J. Pediatric Gastroenterol. Nutr., 24, 189 (1997); Chang, T. et al.: Clin. Pharmacol. Therap., 59, 297 (1996); Wu, S.H.W. et al.: Pharmac. Technol., 23, 52 (1999);

Formula: C₃₃H₅₄O₅(C₂H₄O)n

Color and Shape: Neat

Molecular weight: 530.78 + (44.05)n

Ref: TR-T526075

α-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Formula: C₃₃H₅₄O₅(C₂H₄O)n

Molecular weight: 530.79)( 44.05)n

Ref: ST-EA-CP-T94007

D-α-Tocopheryl polyethylene glycol succinate

CAS: 9002-96-4

D-alpha-Tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that is active in inhibiting chronic myeloid leukemia. TPGS has been shown to be effective against the resistant K562 cells and may be used as a treatment for chronic myeloid leukemia. This drug binds to the enzyme urokinase-type plasminogen activator, which is essential for cancer cell migration and invasion of tumor tissue. It also inhibits tyrosine kinase, which plays an important role in the development of cancer cells by regulating cellular growth and proliferation. TPGS has been shown to have low bioavailability in humans and is not detectable in plasma after oral administration.

Formula: C₃₃H₅₄O₅•(C₂H₄O)n

Purity: Min. 25.0%

Color and Shape: White Slightly Brown Solidified Mass

Ref: 3D-FT40328

Poly(oxy-1,2-ethanediyl),a-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

CAS: 9002-96-4

Formula: C₃₉H₆₆O₈

Color and Shape: Solid

Molecular weight: 662.9365

Ref: IN-DA00IFZ3