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CAS 912-60-7

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Noscapine hydrochloride

Description:
Noscapine hydrochloride is an alkaloid derived from the opium poppy, Papaver somniferum, and is primarily known for its antitussive (cough suppressant) properties. It is a white to off-white crystalline powder that is soluble in water and alcohol, making it suitable for various pharmaceutical formulations. The compound exhibits a unique mechanism of action, primarily functioning as a non-narcotic cough suppressant without the addictive properties associated with other opiates. Noscapine has also been studied for its potential anticancer effects, as it may inhibit cell division by interfering with microtubule dynamics. Its chemical structure includes a benzylisoquinoline framework, contributing to its biological activity. In terms of safety, noscapine hydrochloride is generally considered to have a favorable safety profile, but like all medications, it should be used under medical supervision to avoid potential side effects or interactions with other drugs. Overall, noscapine hydrochloride represents a significant compound in both therapeutic and research contexts.
Formula:C22H23NO7·ClH
InChI:InChI=1S/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18+;/m1./s1
InChI key:InChIKey=MFLVZFXCSKVCSH-URBRKQAFSA-N
SMILES:O(C)C=1C=2[C@@](N(C)CCC2C=C3C1OCO3)([C@@]4(C=5C(C(=O)O4)=C(OC)C(OC)=CC5)[H])[H].Cl
Synonyms:
  • (5R)-5-[(1S)-4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium
  • (5R)-5-[(1S)-4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-((5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, hydrochloride, (3S)-
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride (1:1), (3S)-
  • 1(3H)Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, hydrochloride, (S-(R*,S*))-
  • 1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv.
  • 1-alpha-Narcotine hydrochloride
  • Capval
  • Ccris 8985
  • Coscopin hydrochloride
  • See more synonyms
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