CAS 935693-62-2

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

Description:

The chemical substance known as 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine, with the CAS number 935693-62-2, is a complex organic compound characterized by its multi-cyclic structure and the presence of various functional groups. It features a quinazolinamine core, which is a bicyclic structure containing both a benzene and a pyrimidine ring, contributing to its potential biological activity. The presence of methoxy groups enhances its lipophilicity, potentially influencing its pharmacokinetic properties. The hexahydro-1,4-diazepine moiety adds to its structural complexity, suggesting possible interactions with biological targets, particularly in the central nervous system. The piperidine ring, substituted with a phenylmethyl group, may also play a role in modulating receptor interactions. Overall, this compound's unique structural features suggest it may possess interesting pharmacological properties, warranting further investigation in medicinal chemistry and drug development contexts.

Formula: C₂₈H₃₈N₆O₂

InChI: InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)

InChI key: InChIKey=OSXFATOLZGZLSK-UHFFFAOYSA-N

SMILES: N(C=1C2=C(N=C(N1)N3CCN(C)CCC3)C=C(OC)C(OC)=C2)C4CCN(CC5=CC=CC=C5)CC4

Synonyms:

• 4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-
• BIX 01294
• 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

2-(Hexahydro-4-Methyl-1H-1,4-Diazaze-1-Yl)-6,7-Dimethoxy-N-[1-(Phenylmethyl)-4-Piperidyl]-4-Quinazoline Amine

CAS: 935693-62-2

2-(Hexahydro-4-Methyl-1H-1,4-Diazaze-1-Yl)-6,7-Dimethoxy-N-[1-(Phenylmethyl)-4-Piperidyl]-4-Quinazoline Amine

Formula: C₂₈H₃₈N₆O₂

Purity: 98%

Molecular weight: 490.64

Ref: 54-OR1025715

BIX-01294

CAS: 935693-62-2

BIX-01294

Formula: C₂₈H₃₈N₆O₂

Purity: 99.5%

Molecular weight: 490.64

Ref: 54-BUP07440

BIX-01294

CAS: 935693-62-2

BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).

Formula: C₂₈H₃₈N₆O₂

Purity: 98.58% - 99.64%

Color and Shape: Solid

Molecular weight: 490.64

Ref: TM-T7697

BIX-01294

CAS: 935693-62-2

N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

Formula: C₂₈H₃₈N₆O₂

Purity: 98%

Molecular weight: 490.64

Ref: IN-DG303980

BIX 01294 base

CAS: 935693-62-2

Formula: C₂₈H₃₈N₆O₂·3HCl

Molecular weight: 600

Ref: 7W-GL8747

BIX 01294

Controlled Product

CAS: 935693-62-2

Applications BIX 01294 is a euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor, induces autophagy and apoptosis in human neuroblastoma cells, specifically human bladder cancer cells.
References Cui, J. et al.: Cancer Cell Int., 15, 1 (2015); Shin, J. et al.: Biochem. Biophys. Res. Comm., 350, 428 (2015);

Formula: C₂₈H₃₈N₆O₂

Color and Shape: Neat

Molecular weight: 490.65

Ref: TR-B591595

Histone Lysine Methyltransferase Inhibitor

CAS: 935693-62-2

The histone lysine methyltransferase inhibitor (HMT) is an epigenetic modulator that inhibits the activity of a group of enzymes called histone lysine methyltransferases. These enzymes are responsible for transferring methyl groups to lysine residues on histones, which affects how tightly DNA is wound around histones. This process is important in regulating changes in gene expression and cell differentiation. HMTs have been shown to be effective as anticancer agents that target cancer cells with high levels of methylation and to inhibit growth factor-β1 induced proliferation in myeloma cells. The chemical inhibitors bix-01294 and toll-like receptor antagonist can also function as HMTs.

Formula: C₂₈H₃₈N₆O₂

Purity: Min. 95%

Molecular weight: 490.64 g/mol

Ref: 3D-KMB69362