CAS 950769-58-1

Quizartinib

Description:

Quizartinib is a small molecule inhibitor primarily used in the treatment of acute myeloid leukemia (AML) with specific mutations in the FLT3 gene. It is classified as a tyrosine kinase inhibitor, targeting the FLT3 receptor, which is often mutated in AML, leading to uncontrolled cell proliferation. The chemical structure of Quizartinib includes a pyrimidine core, which is essential for its biological activity. It exhibits high selectivity for the FLT3 receptor, including both the wild-type and the most common activating mutations, making it a valuable therapeutic agent. Quizartinib is administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its pharmacokinetics indicate a moderate half-life, necessitating careful dosing regimens. Adverse effects may include hematological toxicities, gastrointestinal disturbances, and potential for QT interval prolongation. Overall, Quizartinib represents a targeted approach in the management of FLT3-mutated AML, contributing to advancements in personalized cancer therapy.

Formula: C₂₉H₃₂N₆O₄S

InChI: InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

InChI key: InChIKey=CVWXJKQAOSCOAB-UHFFFAOYSA-N

SMILES: O(CCN1CCOCC1)C=2C=C3C(N4C(S3)=NC(=C4)C5=CC=C(NC(NC=6C=C(C(C)(C)C)ON6)=O)C=C5)=CC2

Synonyms:

• Ac 010220
• Ac-220
• N-(5-tert-Butylisoxazol-3-yl)-N'-[4-[7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
• N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
• N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N′-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
• Quizartinib
• Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N′-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-
• N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC-220
• N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-Morpholin-4-ylethoxy)iMidazo[2,1-b][1,3]benzothiazol-2-yl]
• quizartinib (FLT3 inhibitor)
• AC220 (Quizartinib)
• 2-(4-AMinophenyl)-7-(2-Morpholin-4-yl-ethoxy)iMidazo[2,1-b]-[1,3]benzothiazole
• AC220 (Quizartinib, AC010220)
• 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-Morpholinoethoxy)benzo[d]iMidazo[2,1-b]thiazol-2-yl)phenyl)urea
• Quizartinib AC-220
• AC220, AC010220

N-(5-tert-Butylisoxazol-3-yl)-N'-[4-[7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea

CAS: 950769-58-1

Formula: C₂₉H₃₂N₆O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 560.6672

Ref: IN-DA003A8H

Quizartinib

CAS: 950769-58-1

1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea

Formula: C₂₉H₃₂N₆O₄S

Purity: 98%

Molecular weight: 560.67

Ref: IN-DG232319

Quizartinib

CAS: 950769-58-1

Quizartinib

Formula: C₂₉H₃₂N₆O₄S

Purity: ≥98%

Molecular weight: 560.67

Ref: 54-BUP15586

Quizartinib

CAS: 950769-58-1

Quizartinib

Purity: 99%

Color and Shape: off-white to beige solid

Molecular weight: 560.67g/mol

Ref: 54-BIFK0001

Quizartinib

CAS: 950769-58-1

Ref: 7W-GW2178

Quizartinib

CAS: 950769-58-1

Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.

Formula: C₂₉H₃₂N₆O₄S

Purity: 98% - 99.42%

Color and Shape: Solid

Molecular weight: 560.67

Ref: TM-T2066

Quizartinib

CAS: 950769-58-1

Formula: C₂₉H₃₂N₆O₄S

Molecular weight: 560.67

Ref: 4Z-Q-025001

Quizartinib

CAS: 950769-58-1

Inhibitor of FLT3 receptor tyrosine kinases; anti-neoplastic

Formula: C₂₉H₃₂N₆O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 560.67 g/mol

Ref: 3D-FQ32834

AC 220

Controlled Product

CAS: 950769-58-1

Applications AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
References Zarrinkar, P., et al.: Blood, 114, 2984 (2009); Sato, T., et al.: Blood, 117, 3286 (2011)

Formula: C₂₉H₃₂N₆O₄S

Color and Shape: Neat

Molecular weight: 560.67

Ref: TR-A115000