CAS 988-75-0

N-[(Phenylmethoxy)carbonyl]-L-α-glutamyl-L-tyrosine

Description:

N-[(Phenylmethoxy)carbonyl]-L-α-glutamyl-L-tyrosine, with the CAS number 988-75-0, is a synthetic compound that belongs to the class of amino acid derivatives. This substance features a phenylmethoxycarbonyl group attached to the glutamic acid moiety, which is further linked to the amino acid tyrosine. The presence of the phenylmethoxy group enhances its lipophilicity, potentially influencing its biological activity and solubility in organic solvents. The compound is characterized by its peptide-like structure, which may exhibit specific interactions with biological targets, making it of interest in medicinal chemistry and drug design. Its molecular structure suggests potential applications in pharmaceuticals, particularly in the development of prodrugs or compounds with improved bioavailability. Additionally, the presence of both acidic (from glutamic acid) and aromatic (from tyrosine) functionalities may contribute to its reactivity and interaction with various biological systems. As with many amino acid derivatives, it may also exhibit specific stereochemical properties that can affect its biological function.

Formula: C₂₂H₂₄N₂O₈

InChI: InChI=1S/C22H24N2O8/c25-16-8-6-14(7-9-16)12-18(21(29)30)23-20(28)17(10-11-19(26)27)24-22(31)32-13-15-4-2-1-3-5-15/h1-9,17-18,25H,10-13H2,(H,23,28)(H,24,31)(H,26,27)(H,29,30)/t17-,18-/m0/s1

InChI key: InChIKey=XLUMOZQZGPJGTL-ROUUACIJSA-N

SMILES: C([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CCC(O)=O)=O)C(O)=O)C2=CC=C(O)C=C2

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Tyrosine, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-α-glutamyl-
• <span class="text-smallcaps">L</smallcap>-Tyrosine, N-[N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-α-glutamyl]-
• Benzyloxycarbonyl-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-Benzyloxycarbonyl-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-Carbobenzoxy-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-α-glutamyl-<smallcap>L</span>-tyrosine
• NSC 89651
• Tyrosine, N-(N-carboxy-<span class="text-smallcaps">L</smallcap>-α-glutamyl)-, N-benzyl ester, <smallcap>L</span>-
• Z-Glu-Tyr-Oh
• Tyrosine, N-(N-carboxy-L-α-glutamyl)-, N-benzyl ester, L-
• N-[(Phenylmethoxy)carbonyl]-L-α-glutamyl-L-tyrosine
• n-Carbobenzoxy-L-glutamyl-L-tyrosine
• L-Tyrosine, N-[(phenylmethoxy)carbonyl]-L-α-glutamyl-

Z-Glu-Tyr-OH

CAS: 988-75-0

Substrate for porcine cathepsin A and acid carboxypeptidases from A. niger.and A. kawachii.

Formula: C₂₂H₂₄N₂O₈

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 444.44

Ref: 01-4001669

Z-Glu-Tyr-OH

CAS: 988-75-0

Z-Glu-Tyr-OH

Ref: 54-OR1076717

Z-Glu-Tyr

CAS: 988-75-0

Z-Glu-Tyr is a synthetic substrate of the enzyme cathepsin B. The amino acid sequence of Z-Glu-Tyr has been shown to be identical to the sequence of the natural substrate, L-glutaminyl-L-tyrosine. The activity of the enzyme cathepsin B can be inhibited by Z-Glu-Tyr due to its ability to form a covalent bond with cysteine residues in the active site. This inhibition prevents cleavage of peptide bonds and synthesis of polypeptides, which are necessary for cell growth and division. Z-Glu-Tyr is also an inhibitor of thiol proteases, such as papain and subtilisin, which are enzymes that hydrolyze peptide bonds in proteins.

Formula: C₂₂H₂₄N₂O₈

Purity: Min. 95%

Molecular weight: 444.43 g/mol

Ref: 3D-SEY-3018

Z-Glu-Tyr-OH

CAS: 988-75-0

Z-Glu-Tyr-OH is a disulfide bond with a cavity. It is soluble in acidic solutions and has a cationic surface. Z-Glu-Tyr-OH is an enzyme inhibitor that blocks the activity of α subunit of protein kinase C, which is involved in intracellular signal transduction pathways. The inhibition of this enzyme may lead to apoptosis, or programmed cell death. Z-Glu-Tyr-OH also inhibits fatty acid synthesis by blocking the activity of hydroxylase enzymes, such as 3β-hydroxysteroid dehydrogenase and 17α-hydroxylase. This compound has been shown to inhibit indole-3-propionic acid production by inhibiting the kinetic and sephadex g-100 activities of the enzyme indoleamine 2,3 dioxygenase.

Formula: C₂₂H₂₄N₂O₈

Purity: Min. 95%

Molecular weight: 444.43 g/mol

Ref: 3D-FG110840