CAS 99614-01-4

Ondansetron hydrochloride

Description:

Ondansetron hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It is a white to off-white crystalline powder that is soluble in water and has a molecular formula that reflects its complex structure. The substance exhibits a high affinity for the 5-HT3 receptors, blocking the action of serotonin, which is responsible for triggering nausea and vomiting. Ondansetron hydrochloride is typically administered orally or intravenously, and its pharmacokinetics include rapid absorption and a relatively short half-life, necessitating multiple doses in some treatment regimens. The compound is generally well-tolerated, with common side effects including headache, constipation, and dizziness. It is important to note that while effective, ondansetron should be used with caution in patients with certain medical conditions, and its use during pregnancy should be evaluated carefully. Overall, ondansetron hydrochloride is a critical medication in managing chemotherapy-induced nausea and vomiting, contributing significantly to patient comfort and quality of life during cancer treatment.

Formula: C₁₈H₁₉N₃O·ClH

InChI: InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H

InChI key: InChIKey=MKBLHFILKIKSQM-UHFFFAOYSA-N

SMILES: O=C1C=2C=3C(N(C)C2CCC1CN4C(C)=NC=C4)=CC=CC3.Cl

Synonyms:

• (+-)-2,3-Dihydro-9-Methyl-3-((2-Methylimidazol-1-Yl)Methyl)Carbazol-4(1H)-One Monohydrochloride Dihydrate
• 1,2,3,4-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-9H-carbazol-4-one hydrochloride
• 1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-Imidazol-1-Yl)Methyl]-4H-Carbazol-4-One Hydrochloride Dihydrate
• 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride (1:1)
• 4H-Carbazol-4-One, 1,2,3,9-Tetrahydro-9-Methyl-3-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-, Monohydrochloride, (+-)-, Dihydrate
• 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, monohydrochloride
• 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1)
• 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one monohydrochloride
• 9-Methyl-3-[(2-Methylimidazol-1-Yl)Methyl]-2,3-Dihydro-1H-Carbazol-4-One Dihydrate Hydrochloride
• 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)
• 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate
• Carbazol-4-One Dihydrate
• Emeset
• Gr 38032F
• NSC 665799
• Odansetron Hydrochloride Dihydrate
• Ondansetron HCl
• Ondansetron Hcl Dihydrate
• Ondansetron Hydrochloride Hydrate
• Ondansetron hydrochloride
• Osetron
• Sn 307
• Zofran
• Zofran ODT
• Zophren

Ondansetron Hydrochloride Dihydrate

CAS: 103639-04-9, 99614-01-4, 99614-02-5

Formula: C₁₈H₁₉N₃O·HCl·2H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 365.86

Ref: 3B-O0407

Ondansetron hydrochloride

CAS: 99614-01-4

Ondansetron hydrochloride

Purity: ≥98%

Molecular weight: 329.82g/mol

Ref: 54-BUP11722

Ondansetron HCl

CAS: 99614-01-4

Formula: C₁₈H₁₉N₃O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 293.37 36.46

Ref: 4Z-O-037

Ondansetron hydrochloride

CAS: 99614-01-4

Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation

Formula: C₁₈H₁₉N₃O·HCl

Purity: 99.78%

Color and Shape: White Powder

Molecular weight: 329.82

Ref: TM-T6616

Ondansetron Hydrocloride

CAS: 99614-01-4

Formula: C₁₈H₁₉N₃OHCl

Molecular weight: 293.37 : 36.46

Ref: ST-EA-CP-O10010

Ondansetron hydrochloride - Bio-X ™

CAS: 99614-01-4

Ondansetron is a serotonin 5-HT3 receptor antagonist that has been shown to inhibit the effects of serotonin in the gastrointestinal tract, thereby preventing nausea and vomiting that is caused by cancer chemotherapy. Chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron blocks the initiation of this reflex. The drug binds to receptors on cells in the gastrointestinal tract that are normally activated by serotonin, thereby blocking its effect.

Formula: C₁₈H₂₀N₃OCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 329.82 g/mol

Ref: 3D-BO164177

Ondansetron HCl

CAS: 99614-01-4

Serotonin receptor 5-HT3 antagonist

Formula: C₁₈H₂₀N₃OCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 329.82 g/mol

Ref: 3D-FO65112

Ondansetron Hydrochloride

Controlled Product

CAS: 99614-01-4

Formula: C₁₈H₁₉N₃O·HCl

Color and Shape: Neat

Molecular weight: 329.80

Ref: TR-O655000