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CAS 129-46-4

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Suramin sodium

Description:
Suramin sodium is a complex organic compound primarily known for its use as an antiparasitic agent, particularly in the treatment of African sleeping sickness and certain other parasitic infections. It is a polysulfonated naphthylurea derivative, characterized by its large molecular structure and multiple sulfonate groups, which contribute to its solubility in water. Suramin functions by inhibiting various enzymes and disrupting metabolic processes in parasites, making it effective against Trypanosoma brucei, the causative agent of sleeping sickness. The compound is typically administered intravenously due to its poor oral bioavailability. Suramin sodium is also noted for its potential use in research, particularly in studies related to cancer and viral infections, as it can modulate immune responses. However, it is associated with a range of side effects, including allergic reactions and nephrotoxicity, necessitating careful monitoring during treatment. Overall, Suramin sodium is a significant therapeutic agent with a complex profile of biological activity and safety considerations.
Formula:C51H34N6Na6O23S6
InChI:InChI=1/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChI key:InChIKey=CAUQVVHSBBABOW-UHFFFAOYSA-N
SMILES:N(C(=O)C1=CC(NC(=O)C2=CC(NC(NC3=CC(C(NC4=CC(C(NC=5C6=C(C(S(=O)(=O)O)=CC5)C=C(S(=O)(=O)O)C=C6S(=O)(=O)O)=O)=CC=C4C)=O)=CC=C3)=O)=CC=C2)=C(C)C=C1)C=7C8=C(C(S(=O)(=O)O)=CC7)C=C(S(=O)(=O)O)C=C8S(=O)(=O)O.[Na]
Synonyms:
  • 309F
  • 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, hexasodium salt
  • 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6)
  • 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-, hexasodium salt
  • Bayer 205
  • SURAMIN SODIUM SALT
  • 8-[[4-Methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
  • SURAMINE SODIUM SALT
  • 1,3,5-naphthylenetrisulfonicacid,8,8’-(ureylenebis(m-phenylenecarbonylimino(4
  • SURAMIN HEXASODIUM SALT
  • See more synonyms
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