Amino Acid Derivatives

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH is a peptide that belongs to the group of arginine containing peptides. This peptide has been shown to have minimal toxicity and high specificity against HIV. Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH binds intracellular targets, such as protein kinases and ion channels, which inhibit cellular transformation. The Arg residues in this molecule are essential for its biological properties as they are involved in the binding to these intracellular targets. Arg molecules also have an important role in infectious diseases, as they can inhibit viral replication by interfering with the viral life cycle. In addition, Arg molecules may be useful for treating bowel disease because they can bind to calcium ions (Ca2+) and regulate their levels in cells.

Fmoc-a-Me-Lys(Boc)-OH is a versatile building block that can be used in the synthesis of complex compounds. It is a reagent and speciality chemical, which are substances used in research laboratories. Fmoc-a-Me-Lys(Boc)-OH has been used as an intermediate in the synthesis of drugs such as antihypertensive agents, anticonvulsants, and antibiotics. It has also been used as a reaction component in organic syntheses to produce peptides, polymers, and other compounds with biologically active properties.

Please enquire for more information about H-D-ASN-L-ASP-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-Me-Gly-OtBu·HCl (H-Sar-OtBu·HCl) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Secretoneurin (mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-Lys-Trp-Lys-OH TFA salt is a peptide that binds to DNA and enhances the repair of damaged DNA. It interacts with lysine residues on the DNA strand, which are known to be involved in DNA repair mechanisms. H-Lys-Trp-Lys-OH TFA salt also has some optical properties, as it can bind to tryptophan residues in the fluorescing region of damaged DNA. This peptide was originally designed for use as a fluorescent probe for damaged DNA in living cells, but has since been found to have therapeutic effects on damaged cells.

3,3',5'-Triiodo-D-thyronine is a thyroid hormone that is used in the treatment of hypothyroidism. It is administered by injection or by mouth. 3,3',5'-Triiodo-D-thyronine is an insoluble drug, which means it cannot be dissolved in water. This drug can be injected into the body or taken as a pill. 3,3',5'-Triiodo-D-thyronine has been shown to increase metabolic rate and may also inhibit the growth of certain types of tumors. 3,3',5'-Triiodo-D-thyronine has been used in diagnostic procedures such as iontophoresis and implanting devices to treat prostate cancer. This medication can also be used for cosmetic purposes such as skin rejuvenation and hair loss prevention. 3,3',5'-Triiodo-D-thyronine has two structural isomers: levothyroxine and

Please enquire for more information about Fmoc-2,6-dichloro-L-phenylalanine including the price, delivery time and more detailed product information at the technical inquiry form on this page

This 25 residue peptide was completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibited human cathepsin B with Ki = 2.8 µM and rat cathepsin B with Ki = 2 µM.

A highly amyloidogenic region of lactoferrin.

CA074, a potent inhibitor specific for cathepsin B in vitro (IC₅₀= 2.24 nM for rat liver cathepsin B) and in vivo.

Bachem ID: 4095647.

Bachem ID: 4097460.

Bachem ID: 4097932.

(Leu¹³)-Motilin (human, porcine) has been shown to produce an excitory response in the chicken gastrointestinal tract with a different sensitivity from region to region. The mechanisms of action were different between the proventriculus and the intestinal segments. The motilin analog contracted the intestinal segments by direct action on the smooth muscle cells whereas in the proventriculus it caused contraction and enhancement of electrical field stimulation-induced response through an action on the intramural cholinergic neurons.

Bachem ID: 4041119.

Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.

In contrast to the encephalitogenic rat homolog, myelin oligodendrocyte glycoprotein (35-55) (human) does not appear to be a major T-cell epitope in multiple sclerosis propably due to its lower amount of helical structure formed when dissolved in micellar sodium dodecyl sulfate, a membrane mimicking solvent.

Bachem ID: 4012218.

The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.

WFYpSPR-pNA, chromogenic substrate for Pin1, an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase), that specifically recognizes the phosphoserine-proline bonds present in mitotic phosphoproteins (kcat/Km = 20160 mM⁻¹s⁻¹).

Bachem ID: 4011240.

Bachem ID: 4099858.

This NPY analog is a highly potent and selective ligand for Y₁ receptors in different cell lines and tissues. It has therefore been used to detect the NPY/PYY receptor subtype distribution, e.g., in rat brain. The peptide is also active in vivo, showing an even higher potency than NPY in increasing blood pressure in anesthetized rats.

Bachem ID: 4096115.

Bachem ID: 4007396.

Cyclolinopeptide B has been isolated from the seeds of Linum usitatissimum. It showed potent immunosuppressive activity comparable with that of cyclosporin A.

Main degradation product of NPY in serum and Y2/Y5 receptor agonist.

Bachem ID: 4030725.

Potential impurity of exenatide.

Suc-AEPF-AMC, fluorogenic substrate for the peptidylprolyl isomerase Pin1.

The TNF-α antagonist WP9QY inhibited TNF-α mediated apoptosis and exhibited an IC₅₀ of 5 µM in the binding assay. YCWSQYLCY is the smallest peptidomimetic developed to date that might be used as a lead compound for the next generation of non-peptidic inhibitors. The name WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor(I) complex designated WP9 and the introduction of the amino acids Gln and Tyr.

The peptide RVL-psi[CH2NH]FEA-Nle-amide containing a reduced peptide bond was found to be a competitive inhibitor of the HIV-1 protease (Ki = 50 nM).

Phe-CMK, inhibitor of gramicidin S synthetase 2.

Bachem ID: 4095528.

Degradation product of oxytocin.

Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3.0 nM. Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell.

Chromogenic substrate for trypsin and papain.

This biotinylated LHRH derivative has been used in a functional analysis of the LHRH receptor ligand binding.

Bachem ID: 4095648.

N-Acetyl-L-alanine is the N-acetylated form of L-alanine and is a nonessential amino acid. It is an amide containing one nitrogen atom and two carbonyl groups. The nitrogen can be found in either the alpha or beta position on the amide. The biological properties of N-acetyl-L-alanine are similar to those of L-alanine, as it is used as a substrate for protein synthesis and has been shown to inhibit p21 and epidermal growth factor. The conformational properties of N-acetyl-L-alanine are different from that of L-alanine due to its changed shape, which may affect its biological activity.

DL-Asparagine monohydrate is a white crystalline powder that is soluble in water. It has been used as a building block for the synthesis of various compounds and as a reaction component in chemical research.

Used with EDC for carboxyl-foot printing studies of proteins

Fmoc-D-Val-OH is a synthetic acetal that is used as a substrate for protein modification. It has been shown to bind to the active site of enzymes such as butyrylcholinesterase and esterases, which are involved in the metabolism of fatty acids. Fmoc-D-Val-OH also binds to mammalian cells and can be conjugated with other molecules, such as nanoribbons, to improve their solubility in water.

H-Val-bNA

Fmoc-3-chloro-L-beta-homophenylalanine is a chemical scaffold that can be used in research, as an intermediate, or as a building block. It has a wide range of utility and can be used to create complex compounds with high purity. This product is sold as a solid that is soluble in organic solvents such as dichloromethane, chloroform, and DMF. Fmoc-3-chloro-L-beta-homophenylalanine is also known by its CAS number 270596-40-2.

N-Hippuryl-His-Leu hydrate is a synthetic inhibitor that binds to the active site of mitochondrial ATP synthase and blocks the synthesis of ATP. This molecule has shown an inhibitory effect on the mitochondrial membrane potential, which may be due to its inhibition of ATP synthesis. N-Hippuryl-His-Leu hydrate also inhibits hydrochloric acid and galactose induced angiotensin II formation in rat vascular tissues. It has been used as a pharmaceutical preparation for the treatment of high blood pressure, however it does not have any biological properties that are related to uronic acid or blood pressure regulation.