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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 2121 products of "Angiogenesis"

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  • Ifebemtinib tosylate
    Targetmol
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    Ifebemtinib tosylate

    CAS:
    Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.
    Formula:C35H36F4N6O7S
    Color and Shape:Solid
    Molecular weight:760.76

    Ref: TM-T211841

  • lirucitinib
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    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Formula:C16H25N5OS
    Color and Shape:Solid
    Molecular weight:335.468

    Ref: TM-T205259

  • TGF-βRI inhibitor 3
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    TGF-βRI inhibitor 3

    CAS:
    <p>TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.</p>
    Formula:C21H21NO4
    Color and Shape:Solid
    Molecular weight:351.396

    Ref: TM-T205215

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Color and Shape:Solid
    Molecular weight:413.854

    Ref: TM-T204471

  • Tyrosine kinase-IN-9
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    Tyrosine kinase-IN-9

    CAS:
    <p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>
    Formula:C20H14ClN3O3
    Color and Shape:Solid
    Molecular weight:379.796

    Ref: TM-T205576

  • TrxR/EGFR-IN-1
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    TrxR/EGFR-IN-1

    CAS:
    TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.
    Formula:C24H24AuClFN6O2P
    Color and Shape:Solid
    Molecular weight:710.878

    Ref: TM-T205519

  • NS-062
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    NS-062

    CAS:
    NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.
    Formula:C28H30Cl2F2N6O4
    Color and Shape:Solid
    Molecular weight:623.48

    Ref: TM-T201773

  • EGFR ligand-14
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    EGFR ligand-14

    CAS:
    EGFRligand-14 serves as an EGFR ligand and is utilized in the synthesis of SJF-1521.
    Formula:C27H19ClFN3O
    Color and Shape:Solid
    Molecular weight:455.91

    Ref: TM-T212305

  • EGFR-IN-38
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    EGFR-IN-38

    CAS:
    EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63283

  • EGFR-IN-134
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    EGFR-IN-134

    EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.
    Formula:C36H30N6O5
    Color and Shape:Solid
    Molecular weight:626.66

    Ref: TM-T201573

  • FGFR1 inhibitor-17
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    FGFR1 inhibitor-17

    CAS:
    FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.
    Formula:C16H13ClN2O3
    Color and Shape:Solid
    Molecular weight:316.739

    Ref: TM-T205365

  • EG31
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    EG31

    CAS:
    EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.
    Formula:C30H13Br2N3O6
    Color and Shape:Solid
    Molecular weight:671.25

    Ref: TM-T207269

  • Ersentilide
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    Ersentilide

    CAS:
    Ersentilide, a benzamide derivative, functions as both a β1-adrenergic receptor antagonist and an Ikr blocker. It has demonstrated efficacy in animal models of cardiac arrhythmias.
    Formula:C21H26N4O5S
    Color and Shape:Solid
    Molecular weight:446.52

    Ref: TM-T201538

  • Tyk2-IN-17
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    Tyk2-IN-17

    CAS:
    <p>Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].</p>
    Formula:C20H20F2N8O
    Color and Shape:Solid
    Molecular weight:426.42

    Ref: TM-T87586

  • VEGFR-2-IN-26
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    VEGFR-2-IN-26

    CAS:
    VEGFR-2-IN-26 inhibits VEGFR-2 (IC50: 15.5 nM), combating various cancers' cell growth.
    Formula:C24H19F3N6O2
    Color and Shape:Solid
    Molecular weight:480.44

    Ref: TM-T63168

  • FAK-IN-23
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    FAK-IN-23

    CAS:
    <p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>
    Formula:C32H38F3N5O8
    Color and Shape:Solid
    Molecular weight:677.668

    Ref: TM-T204586

  • Flonoltinib sulfate
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    Flonoltinib sulfate

    CAS:
    Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.
    Formula:C25H36FN7O5S
    Color and Shape:Solid
    Molecular weight:565.661

    Ref: TM-T204180

  • HSN748
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    HSN748

    CAS:
    HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.
    Formula:C27H24F3N7O
    Color and Shape:Solid
    Molecular weight:519.521

    Ref: TM-T204396

  • BPI-15086
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    BPI-15086

    CAS:
    BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.
    Formula:C29H33ClN8O4
    Color and Shape:Solid
    Molecular weight:593.08

    Ref: TM-T200004

  • TZEP7
    Targetmol
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    TZEP7

    CAS:
    <p>TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.</p>
    Formula:C27H19ClFNS
    Color and Shape:Solid
    Molecular weight:443.963

    Ref: TM-T205353