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Bcr-Abl

Bcr-Abl

Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.

Found 102 products of "Bcr-Abl"

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  • BGB659
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    BGB659

    CAS:
    <p>BGB659 is effective inhibitor of RAF.</p>
    Formula:C29H29F3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.56

    Ref: TM-T23786

  • Tyrphostin AG 568
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    Tyrphostin AG 568

    CAS:
    <p>Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.</p>
    Formula:C13H9N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.24

    Ref: TM-T24912

  • BCR-ABL-IN-5
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    BCR-ABL-IN-5

    CAS:
    <p>BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.</p>
    Formula:C25H21Cl2N5O2
    Color and Shape:Solid
    Molecular weight:494.37

    Ref: TM-T63332

  • AFG210
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    AFG210

    CAS:
    <p>AFG210 is a novel first-generation “type II” FLT3 inhibitor.</p>
    Formula:C19H14F3N3O2
    Color and Shape:Solid
    Molecular weight:373.33

    Ref: TM-T69702

  • AP 24149
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    AP 24149

    CAS:
    <p>AP 24149, a potent dual inhibitor targeting Src and Abl, exhibits IC50 values of 9.1 nM for Src and 3.6 nM for Abl, respectively.</p>
    Formula:C23H24N5OP
    Color and Shape:Solid
    Molecular weight:417.44

    Ref: TM-T73345

  • CpCDPK1/TgCDPK1-IN-1
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    CpCDPK1/TgCDPK1-IN-1

    CAS:
    <p>CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.</p>
    Formula:C18H17N5
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:303.36

    Ref: TM-T78605

  • BCR-ABL-IN-2
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    BCR-ABL-IN-2

    CAS:
    <p>BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).</p>
    Formula:C24H25Cl2N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:502.39

    Ref: TM-T10489

  • PF-06651481-00
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    PF-06651481-00

    CAS:
    <p>PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.</p>
    Formula:C26H29Cl2N5O3
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:530.45

    Ref: TM-T28374

  • BCR-ABL-IN-1
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    BCR-ABL-IN-1

    CAS:
    <p>BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.</p>
    Formula:C23H21F4N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.44

    Ref: TM-T10488

  • LS-104
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    LS-104

    CAS:
    <p>LS-104 is a JAK2 inhibitor.</p>
    Formula:C19H16N2O3
    Color and Shape:Solid
    Molecular weight:320.34

    Ref: TM-T69348

  • PD-173956
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    PD-173956

    CAS:
    <p>PD-173956 is an inhibitor of the Src family tyrosine kinases.</p>
    Formula:C20H13Cl2FN4O
    Color and Shape:Solid
    Molecular weight:415.25

    Ref: TM-T28345

  • PPY A
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    PPY A

    CAS:
    <p>PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cells</p>
    Formula:C22H20N4O2
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:372.42

    Ref: TM-T23182

  • Nilotinib hydrochloride
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    Nilotinib hydrochloride

    CAS:
    <p>Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.</p>
    Formula:C28H23ClF3N7O
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:565.98

    Ref: TM-T22378

  • Pivanex
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    Pivanex

    CAS:
    <p>Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.</p>
    Formula:C10H18O4
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:202.25

    Ref: TM-T16545

  • BCR-ABL-IN-4
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    BCR-ABL-IN-4

    CAS:
    <p>BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).</p>
    Formula:C27H24ClF2N5O4
    Color and Shape:Solid
    Molecular weight:555.96

    Ref: TM-T63932

  • Risvodetinib
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    Risvodetinib

    CAS:
    <p>Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.</p>
    Formula:C33H34N8O2
    Color and Shape:Solid
    Molecular weight:574.68

    Ref: TM-T69979

  • CT-721
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    CT-721

    CAS:
    <p>CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.</p>
    Formula:C30H29ClN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:525.04

    Ref: TM-T10897

  • HG-7-86-01
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    HG-7-86-01

    CAS:
    <p>HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).</p>
    Formula:C28H21F3N6O2S
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:562.57

    Ref: TM-T86575

  • Tyrosine kinase-IN-9
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    Tyrosine kinase-IN-9

    CAS:
    <p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>
    Formula:C20H14ClN3O3
    Color and Shape:Solid
    Molecular weight:379.796

    Ref: TM-T205576

  • PP487
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    PP487

    CAS:
    <p>PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and &lt; 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].</p>
    Formula:C14H14BrN5O
    Color and Shape:Solid
    Molecular weight:348.2

    Ref: TM-T87238