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Bcr-Abl

Bcr-Abl

Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.

Found 102 products of "Bcr-Abl"

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  • Asciminib
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    Asciminib

    CAS:
    <p>Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).</p>
    Formula:C20H18ClF2N5O3
    Purity:98.82% - 99.70%
    Color and Shape:Solid
    Molecular weight:449.84

    Ref: TM-T5177

  • Imatinib
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    Imatinib

    CAS:
    <p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>
    Formula:C29H31N7O
    Purity:99.42% - 99.94%
    Color and Shape:Off White Powder
    Molecular weight:493.6

    Ref: TM-T6230

  • XL228
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    XL228

    CAS:
    <p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>
    Formula:C22H31N9O
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:437.54

    Ref: TM-T17267

  • Bafetinib
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    Bafetinib

    CAS:
    <p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>
    Formula:C30H31F3N8O
    Purity:94.16% - 99.68%
    Color and Shape:Solid
    Molecular weight:576.62

    Ref: TM-T6311

  • GNF-5
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    GNF-5

    CAS:
    <p>GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.</p>
    Formula:C20H17F3N4O3
    Purity:98% - 99.94%
    Color and Shape:Solid
    Molecular weight:418.37

    Ref: TM-T1803

  • Flumatinib mesylate
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    Flumatinib mesylate

    CAS:
    <p>Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.</p>
    Formula:C30H33F3N8O4S
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:658.69

    Ref: TM-T7861

  • CZC-8004
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    CZC-8004

    CAS:
    <p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>
    Formula:C17H16FN5
    Purity:99.29%
    Color and Shape:Solid
    Molecular weight:309.34

    Ref: TM-T7186

  • Adaphostin
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    Adaphostin

    CAS:
    <p>Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.</p>
    Formula:C24H27NO4
    Purity:98.29%
    Color and Shape:Solid
    Molecular weight:393.48

    Ref: TM-T22553

  • Nilotinib monohydrochloride monohydrate
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    Nilotinib monohydrochloride monohydrate

    CAS:
    <p>Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosine</p>
    Formula:C28H22F3N7O·HCl·H2O
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:583.99

    Ref: TM-T2147

  • AST 487
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    AST 487

    CAS:
    <p>AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.</p>
    Formula:C26H30F3N7O2
    Purity:98.17% - 99.56%
    Color and Shape:Solid
    Molecular weight:529.56

    Ref: TM-T4053

  • PD173955
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    PD173955

    CAS:
    <p>PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and</p>
    Formula:C21H16Cl2N4OS
    Purity:98.52% - 98.99%
    Color and Shape:Solid
    Molecular weight:443.35

    Ref: TM-T3063

  • Bosutinib hydrate
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    Bosutinib hydrate

    CAS:
    <p>Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of leukemia.</p>
    Formula:C26H31Cl2N5O4
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:548.46

    Ref: TM-T63875

  • BCR-ABL-IN-7
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    BCR-ABL-IN-7

    CAS:
    <p>BCR-ABL-IN-7 is an inhibitor of ABL kinase activity in WT and T315I mutants.BCR-ABL-IN-7 can be used in chronic myeloid leukemia (CML) research.</p>
    Formula:C19H16FN3O3S
    Purity:98.28%
    Color and Shape:Solid
    Molecular weight:385.41

    Ref: TM-T72958

  • BCR-ABL1-IN-1
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    BCR-ABL1-IN-1

    CAS:
    <p>BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.</p>
    Formula:C18H12F3N3O2
    Color and Shape:Solid
    Molecular weight:359.3

    Ref: TM-T61324

  • Debio 0617B
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    Debio 0617B

    CAS:
    <p>Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.</p>
    Formula:C28H23ClF3N7O2
    Color and Shape:Solid
    Molecular weight:581.98

    Ref: TM-T64110

  • Antiproliferative agent-30
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    Antiproliferative agent-30

    CAS:
    <p>Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against</p>
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.49

    Ref: TM-T79322

  • BCR-ABL-IN-6
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    BCR-ABL-IN-6

    CAS:
    <p>BCR-ABL-IN-6, an imatinib derivative, inhibits Bcr-AblWT (4.6 nM IC50) and T315I (277 nM), for chronic myeloid leukemia study.</p>
    Formula:C27H22F3N5O2
    Color and Shape:Solid
    Molecular weight:505.49

    Ref: TM-T63450

  • c-ABL-IN-2
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    c-ABL-IN-2

    CAS:
    <p>C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.</p>
    Formula:C21H20N4O
    Color and Shape:Solid
    Molecular weight:344.41

    Ref: TM-T61128

  • AN-019
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    AN-019

    CAS:
    <p>AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.</p>
    Formula:C25H17F6N5O
    Purity:98.99%
    Color and Shape:Solid
    Molecular weight:517.43

    Ref: TM-T26625

  • CHMFL-ABL-053
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    CHMFL-ABL-053

    CAS:
    <p>CHMFL-ABL-053: potent, selective BCR-ABL/SRC/p38 inhibitor (IC50: 70/90/62 nM). Orally available, potential CML drug.</p>
    Formula:C28H26F3N7O2
    Color and Shape:Solid
    Molecular weight:549.55

    Ref: TM-T22067