BTK

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has …

Btk inhibitor 2 is a BTK inhibitor extracted from patent US 20170224688 A1 (BGB-3111 analog).

IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A …

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 …

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s …

Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor.

PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK …

ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for …

G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is …

Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, …

PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an …

Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr …

Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) …

GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical …

N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with …

SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor …

(±)-Zanubrutinib is a specific, potent and orally available Btk inhibitor.

Tirabrutinib (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain …

BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor …

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of …

BMS986195 is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all …

ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral …

BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).

Fenebrutinib is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).

TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed …

RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).

Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) …

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib inhibits diverse BTK …

Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of …

Zanubrutinib is an inhibitor of Bruton tyrosine kinase (BTK).

Ibrutinib deacryloylpiperidine is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 …

BTK IN-1 (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).

CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.

CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an …

CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).

LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other …

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in …

BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd …

BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 …