TNF
TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.
Found 92 products of "TNF"
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Azintuxizumab
CAS:<p>Azintuxizumab, an IgG4 bispecific antibody, targets BCMA, offering dual-action immunotherapy for relapsed/refractory multiple myeloma in preclinical studies.</p>Purity:95% - 95%Color and Shape:LiquidInezetamab
CAS:<p>Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] .</p>Purity:95% - 95%Color and Shape:LiquidBleselumab
CAS:<p>Bleselumab (ASKP 1240) is a humanised monoclonal antibody targeting CD40, inhibiting immune responses, organ transplant rejection.</p>Purity:95%Color and Shape:LiquidTabalumab
CAS:<p>Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.</p>Purity:95%Color and Shape:LiquidIvuxolimab
CAS:<p>Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.</p>Purity:95% - 95%Color and Shape:LiquidCifurtilimab
CAS:<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Purity:95%Color and Shape:LiquidAfimkibart
CAS:<p>Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.</p>Purity:95% - 95%Color and Shape:SoildRavagalimab
CAS:<p>Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.</p>Purity:95% - 95%Color and Shape:LiquidFrexalimab
CAS:<p>Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].</p>Color and Shape:LiquidAfelimomab
CAS:<p>Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].</p>Color and Shape:LiquidTecaginlimab
CAS:<p>Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.</p>Color and Shape:LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
<p>Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.</p>Color and Shape:Odour LiquidIratumumab
CAS:<p>Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.</p>Color and Shape:LiquidIA-14069
CAS:<p>IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.</p>Formula:C20H15ClF2O4Color and Shape:SoildMolecular weight:392.78Cot inhibitor-2
CAS:<p>Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.</p>Formula:C26H25Cl2FN8Purity:98.87%Color and Shape:SolidMolecular weight:539.43Selicrelumab
CAS:<p>Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.</p>Purity:98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Color and Shape:LiquidVU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formula:C25H27N5O2Purity:99.73%Color and Shape:SolidMolecular weight:429.51TNF-α-IN-1
CAS:<p>TNF-α-IN-1 is a TNF-α inhibitor.</p>Formula:C16H14ClN3O5Purity:98.82%Color and Shape:SolidMolecular weight:363.75UCB-5307
CAS:<p>UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.</p>Formula:C22H21N3OPurity:98.76%Color and Shape:SolidMolecular weight:343.42Cot inhibitor-1
CAS:<p>Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.</p>Formula:C27H27Cl2FN8Purity:98.59%Color and Shape:SolidMolecular weight:553.46
