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TNF

TNF

TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.

Found 92 products of "TNF"

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  • CymitQuimica logo
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    Mitazalimab

    CAS:
    <p>Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.</p>
    Purity:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)
    Color and Shape:Liquid

    Ref: TM-T77090

  • SPD304 dihydrochloride
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    SPD304 dihydrochloride

    CAS:
    <p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>
    Formula:C32H34Cl2F3N3O2
    Purity:99.25%
    Color and Shape:Solid
    Molecular weight:620.53

    Ref: TM-T12985

  • GSK2593074A
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    GSK2593074A

    CAS:
    <p>GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.</p>
    Formula:C27H23N5OS
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:465.57

    Ref: TM-T11484

  • BMS-561392
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    BMS-561392

    CAS:
    <p>BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.</p>
    Formula:C27H32N4O4
    Purity:99.16%
    Color and Shape:Solid
    Molecular weight:476.57

    Ref: TM-T30531

  • PK68
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    PK68

    CAS:
    <p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>
    Formula:C22H24N4O3S
    Purity:98.09% - 99.64%
    Color and Shape:Solid
    Molecular weight:424.52

    Ref: TM-T12493

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46

    Ref: TM-T13231L

  • C 87
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    C 87

    CAS:
    <p>C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.</p>
    Formula:C24H15ClN6O3S
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:502.93

    Ref: TM-T14848

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    Boserolimab

    CAS:
    <p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>
    Color and Shape:Liquid

    Ref: TM-T80567

  • CDC801
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    CDC801

    CAS:
    <p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>
    Formula:C23H24N2O5
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:408.45

    Ref: TM-T10730

  • TNF-α-IN-2
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    TNF-α-IN-2

    CAS:
    <p>TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.</p>
    Formula:C25H21ClF2N6O
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:494.92

    Ref: TM-T36097

  • TNF-α-IN-14
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    TNF-α-IN-14

    CAS:
    <p>TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].</p>
    Formula:C22H26O6
    Color and Shape:Solid
    Molecular weight:386.44

    Ref: TM-T87541

  • TNF-α-IN-12
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    TNF-α-IN-12

    CAS:
    <p>TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].</p>
    Formula:C21H22O6
    Color and Shape:Solid
    Molecular weight:370.4

    Ref: TM-T87539