Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Found 125 products of "Caspase"
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Crustecdysone
CAS:<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Formula:C27H44O7Purity:99.06% - 99.67%Color and Shape:Canary Yellow Fine PowderMolecular weight:480.63Diclofenac diethylamine
CAS:<p>Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).</p>Formula:C18H22Cl2N2O2Purity:99.81% - 99.87%Color and Shape:SolidMolecular weight:369.29Lacidipine
CAS:<p>Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.</p>Formula:C26H33NO6Purity:99.98%Color and Shape:White-To-Off-White Crystalline SolidMolecular weight:455.54Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Formula:C8H12BrNO3Purity:98.22% - 99.88%Color and Shape:Beige To Brown Fine Crystalline PowderMolecular weight:250.09Terfenadine
CAS:<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Formula:C32H41NO2Purity:98.76% - 99.75%Color and Shape:SolidMolecular weight:471.67Ac-YVAD-CMK
CAS:<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Formula:C24H33ClN4O8Purity:97.08% - 99.909%Color and Shape:SolidMolecular weight:540.99Q-VD-OPH
CAS:<p>Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.</p>Formula:C26H25F2N3O6Purity:97.8% - 98.95%Color and Shape:SolidMolecular weight:513.5ML-9
CAS:<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Formula:C15H18Cl2N2O2SPurity:99.69%Color and Shape:Crystalline SolidMolecular weight:361.29Thiabendazole
CAS:<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Formula:C10H7N3SPurity:99.14%Color and Shape:Light Yellow PowderMolecular weight:201.25Diclofenac sodium
CAS:<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Formula:C14H10Cl2NNaO2Purity:98.21% - 99.73%Color and Shape:White Or Off-White PowderMolecular weight:318.13Diclofenac
CAS:<p>Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.</p>Formula:C14H11Cl2NO2Purity:99.69% - 99.97%Color and Shape:Crystals From Ether-Petroleum Ether SolidMolecular weight:296.15Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Formula:C8H12ClNO3Purity:98.34% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64Ac-FLTD-CMK
CAS:<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Formula:C26H37ClN4O8Purity:95.17%Color and Shape:SolidMolecular weight:569.05Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Formula:C16H14O3Purity:98.35% - 98.46%Color and Shape:White SolidMolecular weight:254.28Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Ac-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Color and Shape:Odour SolidCaspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Purity:98%Color and Shape:Odour SolidSanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formula:C40H38O11Color and Shape:SolidMolecular weight:694.72TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Formula:C55H70N8O9Color and Shape:SolidMolecular weight:987.19Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Formula:C32H38F3N5O11Purity:99.16%Color and Shape:SolidMolecular weight:725.67δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formula:C18H20N2O4SPurity:99.85%Color and Shape:SolidMolecular weight:360.43Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Color and Shape:Odour SolidSarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formula:C38H44O12Purity:98%Color and Shape:SolidMolecular weight:692.75Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Color and Shape:Odour SolidZ-VDVA-(DL-Asp)-FMK
CAS:<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Formula:C32H46FN5O11Color and Shape:SolidMolecular weight:695.742Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Formula:C17H22ClNO5Color and Shape:SolidMolecular weight:355.81Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Formula:C22H36N4O9Color and Shape:SolidMolecular weight:500.54IRF1-IN-1
CAS:<p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>Formula:C22H24N4O4SPurity:99.88%Color and Shape:SolidMolecular weight:440.52AKN-028
CAS:<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Formula:C17H14N6Purity:99.88%Color and Shape:SolidMolecular weight:302.33Z-WEHD-FMK
CAS:<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formula:C18H16ClN3O2Purity:99.77%Color and Shape:SolidMolecular weight:341.79BOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Formula:C11H18FNO5Purity:97.02%Color and Shape:SolidMolecular weight:263.26Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formula:C12H13ClN2OPurity:99.4% - 99.97%Color and Shape:SolidMolecular weight:236.7Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formula:C33H41N7O11Color and Shape:SolidMolecular weight:711.729TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49J22352
CAS:<p>J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in</p>Formula:C24H21N3O4Color and Shape:SolidMolecular weight:415.44Almorexant hydrochloride
CAS:<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>Formula:C29H32ClF3N2O3Purity:99.85%Color and Shape:SolidMolecular weight:549.02MX1013
CAS:<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>Formula:C18H23FN2O6Color and Shape:SolidMolecular weight:382.39Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Asperosaponin VI
CAS:<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Formula:C47H76O18Purity:97.15% - 99.79%Color and Shape:SolidMolecular weight:929.1KEA1-97
CAS:<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Formula:C15H9Cl2FN4Purity:97.07%Color and Shape:SolidMolecular weight:335.16CASP3 Activator 1541
CAS:<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Formula:C24H17N3O4Purity:98.84%Color and Shape:SolidMolecular weight:411.41Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Formula:C26H46NNaO7SPurity:99.95%Color and Shape:SolidMolecular weight:539.70Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Formula:C7H4O6Purity:99.03%Color and Shape:SolidMolecular weight:184.1Ac-DEVD-AMC
CAS:<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Formula:C30H37N5O13Purity:98.20%Color and Shape:White PowderMolecular weight:675.64
