Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Found 178 products for "Caspase".
Filter by
Purity percentage
0
100
|
0
|
50
|
90
|
95
|
100
- Lower prices
- Higher prices
- Lower purities
- Higher purities
- Faster estimated delivery
Diethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormula:C13H36Cl4N4Purity:99.79% - 99.86%Color and Shape:SolidMolecular weight:390.26Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.5378AE-848/42025892 2HCl
AE-848/42025892 2HCl selectively induces apoptosis in multiple myeloma cells, sparing normal PBMCs, inhibiting U266 and RPMI8226 viability.Formula:C34H38Cl2N6O2Purity:100%Molecular weight:633.61Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Color and Shape:SolidMolecular weight:952.77Ac-IETD-AFC TFA
Ac-IETD-AFC TFA is a synthetic fluorescent substrate used for the specific detection of Caspase-8 enzyme activity. It contains the fluorescent group AFC (7-amino-4-trifluoromethylcoumarin), which becomes free and emits fluorescence (Ex=~400 nm; Em=~505 nm) when Caspase-8 cleaves the amide bond following the IETD sequence. [INDO 1 pentasodium].Color and Shape:Odour SolidPQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purity:99.77%Color and Shape:SolidMolecular weight:341.79HDAC3 degrader-1
HDAC3degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. It shows minimal impact on HDAC1, HDAC2, and HDAC6. By inhibiting the activation of the NLRP3 inflammasome, HDAC3degrader-1 reduces the secretion of IL-1β and caspase-1. It demonstrates significant efficacy in models of septic shock and colitis, making it valuable for anti-inflammatory research.2,4-Dichlorophenol
CAS:2,4-Dichlorophenol induces ER-stress-mediated apoptosis in mouse embryonic fibroblasts through cellular stress, mitochondrial disruption, caspase-3 activation, and eIF2α dephosphorylation.Formula:C6H4Cl2OPurity:99.88%Molecular weight:163.001Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Color and Shape:SolidMolecular weight:711.729Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Formula:C17H22ClNO5Color and Shape:SolidMolecular weight:355.81Lb54
Lb54 is an activator of caspase-3 and caspase-7 with an EC50 of 660.9 nM for human procaspase-3. It activates caspase-3/7, which cleaves Gasdermin D (GSDMD) at the aspartic acid residue 87 to produce a p10 fragment, thus preventing the formation of the pore-forming p30 fragment of GSDMD. By activating caspase-3/7, Lb54 inhibits GSDMD-mediated pyroptosis, thereby reducing inflammation and providing protection against sepsis. Additionally, Lb54 alleviates acute lung injury and suppresses systemic inflammation by inhibiting the maturation of monocyte-derived dendritic cells. Lb54 is applicable in sepsis-related research.N-Acetyl-L-tryptophan-d3
N-Acetyl-L-tryptophan-d3 is the deuterium-labeled analogue of N-Acetyl-L-tryptophan. This compound functions as an antagonist of the neurokinin receptor (NK-1R), inhibiting the binding of Substance P (SP) to NK-1R and providing neuroprotective effects that improve memory impairment and motor dysfunction. Additionally, N-Acetyl-L-tryptophan acts as an inhibitor of mitochondrial cytochrome c (Cytochrome c), offering antioxidant and anti-inflammatory benefits by reducing IL-1β expression and inhibiting caspase-1 activation. N-Acetyl-L-tryptophan shows potential for research in neurodegenerative and inflammatory disease contexts.Ac-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purity:99.16%Color and Shape:White SolidMolecular weight:725.67Perfluorodecanoic acid
CAS:Controlled ProductPerfluorodecanoic acid is a biochemical.Formula:C10HF19O2Color and Shape:SolidMolecular weight:514.08Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47IRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formula:C18H20N2O4SPurity:99.85%Color and Shape:SolidMolecular weight:360.43Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78NEK7 degrader-3
CAS:NEK7degrader-3 is an orally active NEK7 molecular glue degrader capable of crossing the blood-brain barrier, with a DC50 of 31.1 nM. It facilitates the interaction between NEK7 and the E3 ligase cereblon, promoting NEK7 proteasomal degradation and reducing inflammation mediated by the NLRP3 inflammasome. NEK7degrader-3 inhibits caspase-1 activity, releases cytokines IL-1β, IL-1α, and IL-18, and decreases pyroptosis-related plasma membrane permeability. It shows anti-inflammatory effects in an LPS-induced neuroinflammation mouse model and is useful for studying neuroinflammation.Formula:C16H13Cl2N3O4Molecular weight:382.20Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.Formula:C12H13ClN2OPurity:99.4% - 99.97%Color and Shape:SolidMolecular weight:236.697
