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Caspase

Caspase

Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.

Found 125 products of "Caspase"

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  • BOC-D-FMK
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    BOC-D-FMK

    CAS:
    <p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>
    Formula:C11H18FNO5
    Purity:97.02%
    Color and Shape:Solid
    Molecular weight:263.26

    Ref: TM-T10580

  • (Iso)-Z-VAD(OMe)-FMK
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    (Iso)-Z-VAD(OMe)-FMK

    CAS:
    <p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>
    Formula:C22H30FN3O7
    Purity:97.10%
    Color and Shape:Soild
    Molecular weight:467.49

    Ref: TM-T88862

  • IRF1-IN-1
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    IRF1-IN-1

    CAS:
    <p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>
    Formula:C22H24N4O4S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:440.52

    Ref: TM-T203129

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    Ac-VDVAD-CHO TFA

    <p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206392

  • Protease Inhibitor Library
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    Protease Inhibitor Library

    <p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1100

  • Ac-IEPD-AFC
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    Ac-IEPD-AFC

    CAS:
    <p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>
    Formula:C32H38F3N5O11
    Purity:99.16%
    Color and Shape:Solid
    Molecular weight:725.67

    Ref: TM-TP1128

  • PQ401
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    PQ401

    CAS:
    <p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50&lt;1 μM).</p>
    Formula:C18H16ClN3O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:341.79

    Ref: TM-T2085

  • Z-VDVA-(DL-Asp)-FMK
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    Z-VDVA-(DL-Asp)-FMK

    CAS:
    <p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>
    Formula:C32H46FN5O11
    Color and Shape:Solid
    Molecular weight:695.742

    Ref: TM-T39344

  • Reproxalap
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    Reproxalap

    CAS:
    <p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>
    Formula:C12H13ClN2O
    Purity:99.4% - 99.97%
    Color and Shape:Solid
    Molecular weight:236.7

    Ref: TM-T16732

  • Ac-LEVD-CHO
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    Ac-LEVD-CHO

    CAS:
    <p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>
    Formula:C22H36N4O9
    Color and Shape:Solid
    Molecular weight:500.54

    Ref: TM-T85585

  • Ac-Trp-Glu-His-Asp-Aldehyde
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    Ac-Trp-Glu-His-Asp-Aldehyde

    CAS:
    <p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>
    Formula:C28H33N7O9
    Color and Shape:Solid
    Molecular weight:611.6

    Ref: TM-T76600

  • IRF1-IN-2
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    IRF1-IN-2

    CAS:
    <p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>
    Formula:C18H20N2O4S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:360.43

    Ref: TM-T203076

  • Sanggenon G
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    Sanggenon G

    CAS:
    <p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>
    Formula:C40H38O11
    Color and Shape:Solid
    Molecular weight:694.72

    Ref: TM-T73876

  • Boc-Asp(OBzl)-CMK
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    Boc-Asp(OBzl)-CMK

    CAS:
    <p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>
    Formula:C17H22ClNO5
    Color and Shape:Solid
    Molecular weight:355.81

    Ref: TM-T85867

  • Pralnacasan
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    Pralnacasan

    CAS:
    <p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>
    Formula:C26H29N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:523.54

    Ref: TM-T16570

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    TD1092

    <p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>
    Formula:C55H70N8O9
    Color and Shape:Solid
    Molecular weight:987.19

    Ref: TM-T75010

  • Z-WEHD-FMK
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    Z-WEHD-FMK

    CAS:
    <p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>
    Formula:C37H42FN7O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:763.78

    Ref: TM-TP2161

  • Ac-LEHD-AMC
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    Ac-LEHD-AMC

    CAS:
    <p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>
    Formula:C33H41N7O11
    Color and Shape:Solid
    Molecular weight:711.729

    Ref: TM-T36342

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    Caspase-3 activator 2

    <p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>
    Purity:98%
    Color and Shape:Odour Solid

    Ref: TM-T82775

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    Sarglaroids F

    <p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>
    Formula:C38H44O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:692.75

    Ref: TM-T79992