Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Found 154 products of "Caspase"
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Perfluorodecanoic acid
CAS:Perfluorodecanoic acid is a biochemical.Formula:C10HF19O2Color and Shape:Physical Description Liquid (Ntp 1992)Molecular weight:514.08Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Color and Shape:SolidMolecular weight:952.77TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47Biotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Color and Shape:Odour SolidVCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Color and Shape:Odour SolidRoxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Formula:C17H26N2O3Color and Shape:SolidMolecular weight:306.4Ac-AAVALLPAVLLALLAP-LEHD-CHO
CAS:Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated withFormula:C97H162N22O25Purity:98%Color and Shape:SolidMolecular weight:2036.46Trehalose-6,6'-dibehenate
CAS:Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formula:C56H106O13Color and Shape:SolidMolecular weight:987.43(Iso)-Z-VAD(OMe)-FMK
CAS:(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Color and Shape:Odour SolidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Color and Shape:Odour SolidRef: TM-L1100
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireZ-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Color and Shape:SolidMolecular weight:695.742PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purity:99.77%Color and Shape:SolidMolecular weight:341.79Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formula:C22H36N4O9Color and Shape:SolidMolecular weight:500.54Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Color and Shape:SolidMolecular weight:711.729TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Color and Shape:SolidMolecular weight:987.19Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.
Formula:C12H13ClN2OPurity:99.4% - 99.97%Color and Shape:SolidMolecular weight:236.7Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Formula:C17H22ClNO5Color and Shape:SolidMolecular weight:355.81Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54
