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Caspase

Caspase

Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.

Found 147 products of "Caspase"

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  • GlcNAc-MurNAc
    Targetmol
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    GlcNAc-MurNAc

    CAS:
    GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.
    Formula:C19H32N2O13
    Color and Shape:Solid
    Molecular weight:496.46

    Ref: TM-T211496

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  • ZIF-8
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    ZIF-8

    CAS:
    ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.
    Formula:C4H6N2Zn
    Color and Shape:Solid
    Molecular weight:147.513

    Ref: TM-T205703

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  • Caspase-3-IN-2
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    Caspase-3-IN-2

    CAS:
    Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.
    Formula:C10H6ClNO5
    Color and Shape:Solid
    Molecular weight:255.611

    Ref: TM-T205720

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  • Ac-DMLD-CMK
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    Ac-DMLD-CMK

    CAS:
    Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.
    Formula:C22H35ClN4O9S
    Color and Shape:Solid
    Molecular weight:567.053

    Ref: TM-TP3236

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  • N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
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    N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride

    CAS:
    N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.
    Formula:C14H22Cl2N2O3S
    Molecular weight:369.31

    Ref: TM-T210015

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  • Z-VA-DL-D-FMK
    Targetmol
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    Z-VA-DL-D-FMK

    CAS:
    Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.
    Formula:C21H28FN3O7
    Color and Shape:Solid
    Molecular weight:453.46

    Ref: TM-T88570

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  • NLRP3-IN-81
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    NLRP3-IN-81

    CAS:
    NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
    Formula:C16H15F3N2O3S
    Color and Shape:Solid
    Molecular weight:372.36

    Ref: TM-T210731

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