
Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Found 125 products of "Caspase"
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p-nitro-Pifithrin-α
CAS:<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Formula:C15H16BrN3O3SColor and Shape:SolidMolecular weight:398.27SDZ 224-015
CAS:<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Formula:C30H35Cl2N3O9Purity:95.49% - 95.49%Color and Shape:SolidMolecular weight:652.52VRT-043198
CAS:<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Formula:C22H29ClN4O6Color and Shape:SolidMolecular weight:480.94QM31
CAS:<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Formula:C39H38Cl4N4O4Purity:98%Color and Shape:SolidMolecular weight:768.56N1,N11-Diethylnorspermine
CAS:<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Formula:C13H32N4Color and Shape:SolidMolecular weight:244.42GRI977143
CAS:<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formula:C22H17NO4SPurity:98.07%Color and Shape:SolidMolecular weight:391.44OT-82
CAS:<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Formula:C26H21FN4OPurity:98.91% - 99.315%Color and Shape:SolidMolecular weight:424.47ML132
CAS:<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Formula:C22H28ClN5O5Color and Shape:SolidMolecular weight:477.94CZL55
CAS:<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Formula:C20H22N2O6Purity:98.19%Color and Shape:SolidMolecular weight:386.4NLRP3 agonist 1
CAS:<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Formula:C15H16N6Purity:99.01%Color and Shape:SolidMolecular weight:280.33M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Formula:C21H21N5O2Purity:98%Color and Shape:SolidMolecular weight:375.42Ac-YVAD-pNA
CAS:<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Formula:C29H36N6O10Color and Shape:SolidMolecular weight:628.639GDC-2394
CAS:<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Formula:C20H25N5O4SColor and Shape:SolidMolecular weight:431.51CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formula:C23H26O5Purity:97.07%Color and Shape:SolidMolecular weight:382.45EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Formula:C18H23FN2O6Purity:98%Color and Shape:SolidMolecular weight:382.38M867
CAS:<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Formula:C27H43N7O6Purity:98%Color and Shape:SolidMolecular weight:561.67Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formula:C14H23N3O6Purity:98%Color and Shape:SolidMolecular weight:329.35Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formula:C30H37ClN4O9Purity:98%Color and Shape:SolidMolecular weight:633.09ZIF-8
CAS:<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formula:C4H6N2ZnColor and Shape:SolidMolecular weight:147.513Caspase-3-IN-2
CAS:<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Formula:C10H6ClNO5Color and Shape:SolidMolecular weight:255.611
