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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • Cdc7-IN-1
    Targetmol
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    Cdc7-IN-1

    CAS:
    <p>Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.</p>
    Formula:C21H16ClN3O4
    Color and Shape:Solid
    Molecular weight:409.82

    Ref: TM-T10724

  • CDK9-IN-14
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    CDK9-IN-14

    CAS:
    <p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>
    Formula:C21H23F2N3O4
    Color and Shape:Solid
    Molecular weight:419.42

    Ref: TM-T62203

  • CLK1/2-IN-3
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    CLK1/2-IN-3

    CAS:
    <p>CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.</p>
    Formula:C21H21N5O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T23897

  • THZ1-R
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    THZ1-R

    CAS:
    <p>THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.</p>
    Formula:C31H30ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.07

    Ref: TM-T13153

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    <p>CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).</p>
    Formula:C24H16FN5O
    Color and Shape:Solid
    Molecular weight:409.42

    Ref: TM-T10836

  • CDK12-IN-E9
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    CDK12-IN-E9

    CAS:
    <p>CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.</p>
    Formula:C24H30N6O2
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T14915

  • Cdc7-IN-17
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    Cdc7-IN-17

    CAS:
    <p>Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of &lt;10 μM that can be used in cancer research [1].</p>
    Formula:C13H15N5OS
    Color and Shape:Solid
    Molecular weight:289.36

    Ref: TM-T60589

  • AS2863619 free base
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    AS2863619 free base

    CAS:
    <p>AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.</p>
    Formula:C16H12N8O
    Color and Shape:Solid
    Molecular weight:332.32

    Ref: TM-T10382

  • Cdc7-IN-4
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    Cdc7-IN-4

    CAS:
    <p>Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C22H24F3N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:479.45

    Ref: TM-T10726

  • K 00546
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    K 00546

    CAS:
    <p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>
    Formula:C15H13F2N7O2S2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:425.44

    Ref: TM-T21950

  • CDK8-IN-7
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    CDK8-IN-7

    CAS:
    <p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>
    Formula:C30H40N2
    Color and Shape:Solid
    Molecular weight:428.65

    Ref: TM-T62354

  • Cdc7-IN-15
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    Cdc7-IN-15

    CAS:
    <p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>
    Formula:C12H14N4OS
    Color and Shape:Solid
    Molecular weight:262.33

    Ref: TM-T60427

  • CP681301
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    CP681301

    CAS:
    <p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>
    Formula:C17H22N4O
    Color and Shape:Solid
    Molecular weight:298.38

    Ref: TM-T60661

  • MDK6204
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    MDK6204

    CAS:
    <p>MDK6204 is a selective inhibitor of CLK1 and CLK2.</p>
    Formula:C20H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T24439

  • BSJ-01-175
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    BSJ-01-175

    CAS:
    <p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>
    Formula:C30H33ClN6O2
    Color and Shape:Solid
    Molecular weight:545.08

    Ref: TM-T63841

  • Indirubin-3'-monoxime-5-sulphonic acid
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    Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    <p>Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.</p>
    Formula:C16H11N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.34

    Ref: TM-T11652

  • CDK7-IN-13
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    CDK7-IN-13

    CAS:
    <p>CDK7-IN-13: A potent pyrimidine-based CDK7 inhibitor, potential for various cancers. See CN114249712A.</p>
    Formula:C20H23F3N6OS
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T62759

  • P18IN003
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    P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32

    Ref: TM-T24580

  • CDK7-IN-20
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    CDK7-IN-20

    <p>CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.</p>
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57

    Ref: TM-T73163

  • FLT3/CDK4-IN-1
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    FLT3/CDK4-IN-1

    CAS:
    <p>FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) &amp; CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.</p>
    Formula:C25H28F2N8
    Color and Shape:Solid
    Molecular weight:478.54

    Ref: TM-T63135

  • BS-181
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    BS-181

    CAS:
    <p>BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); &gt;40-fold selective for CDK7 than CDK1/2/4/5/6/9.</p>
    Formula:C22H32N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.53

    Ref: TM-T1947

  • CDK4/6-IN-12
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    CDK4/6-IN-12

    CAS:
    <p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM &amp; 3090 nM, useful in cancer research.</p>
    Formula:C12H10N6
    Color and Shape:Solid
    Molecular weight:238.25

    Ref: TM-T60328

  • CGP60474
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    CGP60474

    CAS:
    <p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>
    Formula:C18H18ClN5O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:355.82

    Ref: TM-T14943

  • CCT068127
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    CCT068127

    CAS:
    <p>CCT068127 is a potent CDK2 and CDK9 inhibitor.</p>
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.46

    Ref: TM-T68913

  • (S)-CR8
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    (S)-CR8

    CAS:
    <p>(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.</p>
    Formula:C24H29N7O
    Color and Shape:Solid
    Molecular weight:431.53

    Ref: TM-T23577

  • CDK7-IN-8
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    CDK7-IN-8

    CAS:
    <p>CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.</p>
    Formula:C25H38N8O3
    Color and Shape:Solid
    Molecular weight:498.62

    Ref: TM-T63381

  • EGFR/HER2/CDK9-IN-3
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    EGFR/HER2/CDK9-IN-3

    CAS:
    <p>EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.</p>
    Formula:C24H21N3O4S2
    Color and Shape:Solid
    Molecular weight:479.57

    Ref: TM-T63161

  • Aloisine A
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    Aloisine A

    CAS:
    <p>Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.</p>
    Formula:C16H17N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.33

    Ref: TM-T21377

  • TP1287
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    TP1287

    CAS:
    <p>TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.</p>
    Formula:C21H21ClNO8P
    Color and Shape:Solid
    Molecular weight:481.82

    Ref: TM-T69965

  • Indirubin-5-sulfonate
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    Indirubin-5-sulfonate

    CAS:
    <p>Indirubin-5-sulfonate inhibits GSK-3β &amp; CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&amp;E, 4/D1, 5/p35.</p>
    Formula:C16H10N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.33

    Ref: TM-T11653

  • Crozbaciclib fumarate
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    Crozbaciclib fumarate

    CAS:
    <p>Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.</p>
    Formula:C32H34F2N6O4
    Color and Shape:Solid
    Molecular weight:604.65

    Ref: TM-T72393

  • CDK7-IN-12
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    CDK7-IN-12

    CAS:
    <p>CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.</p>
    Formula:C20H19F3N6
    Color and Shape:Solid
    Molecular weight:400.4

    Ref: TM-T61922

  • CDK1-IN-1
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    CDK1-IN-1

    CAS:
    <p>CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.</p>
    Formula:C27H23N5O3
    Color and Shape:Solid
    Molecular weight:465.5

    Ref: TM-T62970

  • CDK4/6-IN-9
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    CDK4/6-IN-9

    CAS:
    <p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>
    Formula:C22H23FN8
    Color and Shape:Solid
    Molecular weight:418.47

    Ref: TM-T62192

  • Cdc7-IN-13
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    Cdc7-IN-13

    CAS:
    <p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of &lt;1 nM. This compound holds promise for cancer research [1].</p>
    Formula:C18H20N4O2S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T61288

  • Ulecaciclib
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    Ulecaciclib

    CAS:
    <p>Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).</p>
    Formula:C25H33FN8S
    Color and Shape:Solid
    Molecular weight:496.65

    Ref: TM-T63362

  • FN-1501
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    FN-1501

    CAS:
    <p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>
    Formula:C22H25N9O
    Purity:97.4%
    Color and Shape:Solid
    Molecular weight:431.49

    Ref: TM-T15335

  • JTK-101
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    JTK-101

    CAS:
    <p>JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.</p>
    Formula:C25H23N3O3
    Color and Shape:Solid
    Molecular weight:413.47

    Ref: TM-T24221

  • (E/Z)-BIO-acetoxime
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    (E/Z)-BIO-acetoxime

    CAS:
    <p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>
    Formula:C18H12BrN3O3
    Color and Shape:Solid
    Molecular weight:398.21

    Ref: TM-T61890

  • (S)-LY3177833 hydrate
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    (S)-LY3177833 hydrate

    CAS:
    <p>(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.</p>
    Formula:C16H14FN5O2
    Color and Shape:Solid
    Molecular weight:327.31

    Ref: TM-T72384

  • RP-106
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    RP-106

    CAS:
    <p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>
    Formula:C17H19N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.35

    Ref: TM-T24734

  • PKC-9
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    PKC-9

    CAS:
    <p>PKC-9 is a PKC-zeta inhibitor 9.</p>
    Formula:C25H25N7
    Color and Shape:Solid
    Molecular weight:423.51

    Ref: TM-T71993

  • CDK4/6-IN-7
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    CDK4/6-IN-7

    CAS:
    <p>CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.</p>
    Formula:C18H18ClN5O3
    Color and Shape:Solid
    Molecular weight:387.82

    Ref: TM-T61738

  • Cdc7-IN-3
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    Cdc7-IN-3

    CAS:
    <p>Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C20H22N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:398.41

    Ref: TM-T10725

  • CDK7-IN-2
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    CDK7-IN-2

    CAS:
    <p>CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.</p>
    Formula:C26H39N7O3
    Color and Shape:Solid
    Molecular weight:497.63

    Ref: TM-T63368

  • EGFR/HER2/CDK9-IN-1
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    EGFR/HER2/CDK9-IN-1

    CAS:
    <p>EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.</p>
    Formula:C23H21N3O3S2
    Color and Shape:Solid
    Molecular weight:451.56

    Ref: TM-T62746

  • CDK5 inhibitor 20-223
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    CDK5 inhibitor 20-223

    CAS:
    <p>CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.</p>
    Formula:C19H19N3O
    Color and Shape:Solid
    Molecular weight:305.37

    Ref: TM-T36742

  • FN-1501-propionic acid
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    FN-1501-propionic acid

    CAS:
    <p>FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.</p>
    Formula:C25H27N9O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.54

    Ref: TM-T13696

  • EGFR/HER2/CDK9-IN-2
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    EGFR/HER2/CDK9-IN-2

    CAS:
    <p>EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.</p>
    Formula:C23H20N4O5S2
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T63357

  • CDK8-IN-10
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    CDK8-IN-10

    CAS:
    <p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>
    Formula:C25H15ClF3N5O3
    Color and Shape:Solid
    Molecular weight:525.87

    Ref: TM-T63690

  • CDK4/6-IN-8
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    CDK4/6-IN-8

    CAS:
    <p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>
    Formula:C18H18N6O5
    Color and Shape:Solid
    Molecular weight:398.37

    Ref: TM-T61892

  • AS-0141
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    AS-0141

    CAS:
    <p>AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。</p>
    Formula:C21H22F3N5O4
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:465.43

    Ref: TM-T10728

  • Ryuvidine
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    Ryuvidine

    CAS:
    <p>Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.</p>
    Formula:C15H12N2O2S
    Purity:98.6%
    Color and Shape:Solid
    Molecular weight:284.33

    Ref: TM-T23284

  • (S)-Enitociclib
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    (S)-Enitociclib

    CAS:
    <p>(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.</p>
    Formula:C19H18F2N4O2S
    Purity:98.98%
    Color and Shape:Solid
    Molecular weight:404.43

    Ref: TM-T70388

  • CLK-IN-T3
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    CLK-IN-T3

    CAS:
    <p>CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.</p>
    Formula:C28H30N6O2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:482.58

    Ref: TM-T14980

  • (S)-PF-06873600
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    (S)-PF-06873600

    CAS:
    <p>(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.</p>
    Formula:C20H27F2N5O4S
    Purity:98.59%
    Color and Shape:Solid
    Molecular weight:471.52

    Ref: TM-T12809

  • CDK9-IN-10
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    CDK9-IN-10

    CAS:
    <p>CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.</p>
    Formula:C22H16O5
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:360.36

    Ref: TM-T10742

  • PS423
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    PS423

    CAS:
    <p>PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.</p>
    Formula:C25H23F3O9
    Purity:98.81% - 99.26%
    Color and Shape:Solid
    Molecular weight:524.44

    Ref: TM-T24676

  • HTH-01-091
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    HTH-01-091

    CAS:
    <p>HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,</p>
    Formula:C26H28Cl2N4O2
    Purity:98.4%
    Color and Shape:Solid
    Molecular weight:499.43

    Ref: TM-T24152

  • hSMG-1 inhibitor 11e
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    hSMG-1 inhibitor 11e

    CAS:
    <p>hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 &lt;0.05 nM) and can be used in studies about cancer treatment.</p>
    Formula:C26H27N7O3S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:517.6

    Ref: TM-T35529

  • CDK-IN-2
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    CDK-IN-2

    CAS:
    <p>CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: &lt;8 nM).</p>
    Formula:C18H19ClFN3O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-TQ0078

  • 9-Isopropylolomoucine
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    9-Isopropylolomoucine

    CAS:
    <p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>
    Formula:C17H22N6O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:326.4

    Ref: TM-T23589

  • CDK8-IN-1
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    CDK8-IN-1

    CAS:
    <p>CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).</p>
    Formula:C11H8F3N3O
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:255.2

    Ref: TM-T10740

  • Cdc7-IN-7c
    Targetmol
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    Cdc7-IN-7c

    CAS:
    <p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>
    Formula:C15H17N5OS
    Purity:98.19% - 99.22%
    Color and Shape:Solid
    Molecular weight:315.39

    Ref: TM-T23867

  • SEL120-34A
    Targetmol
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    SEL120-34A

    CAS:
    <p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) &amp; CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>
    Formula:C15H18Br2N4
    Purity:99.764% - 99.84%
    Color and Shape:Solid
    Molecular weight:414.14

    Ref: TM-T10744

  • CDK4/6/1 Inhibitor
    Targetmol
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    CDK4/6/1 Inhibitor

    CAS:
    <p>CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).</p>
    Formula:C28H30F2N6
    Purity:99.26% - 99.72%
    Color and Shape:Solid
    Molecular weight:488.57

    Ref: TM-T10735

  • BML-259
    Targetmol
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    BML-259

    CAS:
    <p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>
    Formula:C14H16N2OS
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:260.35

    Ref: TM-T36964

  • dCeMM2
    Targetmol
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    dCeMM2

    CAS:
    <p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>
    Formula:C16H11ClN6OS
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:370.82

    Ref: TM-T61477

  • Cdk2 Inhibitor II
    Targetmol
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    Cdk2 Inhibitor II

    CAS:
    <p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>
    Formula:C14H11BrN4O3S
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:395.23

    Ref: TM-T36933

  • Abemaciclib metabolite M20
    Targetmol
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    Abemaciclib metabolite M20

    CAS:
    <p>Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。</p>
    Formula:C27H32F2N8O
    Purity:98.1% - 99.08%
    Color and Shape:Solid
    Molecular weight:522.59

    Ref: TM-T10738

  • SHP2/CDK4-IN-1
    Targetmol
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    SHP2/CDK4-IN-1

    CAS:
    <p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>
    Formula:C33H35ClF2N10OS
    Color and Shape:Solid
    Molecular weight:693.21

    Ref: TM-T72836

  • CDK-IN-11
    Targetmol
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    CDK-IN-11

    CAS:
    <p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>
    Formula:C25H21BrN4O2
    Color and Shape:Solid
    Molecular weight:489.36

    Ref: TM-T84917

  • CDK/HDAC-IN-3
    Targetmol
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    CDK/HDAC-IN-3

    CAS:
    <p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>
    Formula:C24H18Cl2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.34

    Ref: TM-T78906

  • Cdk4 Inhibitor
    Targetmol
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    Cdk4 Inhibitor

    CAS:
    <p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 &lt; 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>
    Formula:C20H10BrN3O2
    Color and Shape:Solid
    Molecular weight:404.2

    Ref: TM-T84413

  • EHT 5372
    Targetmol
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    EHT 5372

    CAS:
    <p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>
    Formula:C17H11Cl2N5OS
    Color and Shape:Solid
    Molecular weight:404.27

    Ref: TM-T61985

  • Nε-(1-Carboxyethyl)-L-lysine
    Targetmol
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    Nε-(1-Carboxyethyl)-L-lysine

    CAS:
    <p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>
    Formula:C9H18N2O4
    Color and Shape:Solid
    Molecular weight:218.25

    Ref: TM-T85157

  • Lerociclib
    Targetmol
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    Lerociclib

    CAS:
    <p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>
    Formula:C26H34N8O
    Purity:99%
    Color and Shape:Solid
    Molecular weight:474.6

    Ref: TM-T11345

  • CDK8-IN-3
    Targetmol
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    CDK8-IN-3

    CAS:
    <p>CDK8-IN-3 is an inhibitor of CDK8.</p>
    Formula:C22H23N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T14917

  • CDK9-IN-29
    Targetmol
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    CDK9-IN-29

    CAS:
    <p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>
    Formula:C29H33F2N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.6

    Ref: TM-T82757

  • IIIM-290
    Targetmol
    + Info

    IIIM-290

    CAS:
    <p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>
    Formula:C23H21Cl2NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.32

    Ref: TM-T11632

  • CCT-251921
    Targetmol
    + Info

    CCT-251921

    CAS:
    <p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>
    Formula:C21H23ClN6O
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:410.9

    Ref: TM-T14901

  • CDK9-IN-8
    Targetmol
    + Info

    CDK9-IN-8

    CAS:
    <p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>
    Formula:C31H32FN7O3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:569.63

    Ref: TM-T10746

  • QR-6401
    Targetmol
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    QR-6401

    CAS:
    <p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>
    Formula:C19H23N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.42

    Ref: TM-T79014

  • Tacaciclib
    Targetmol
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    Tacaciclib

    CAS:
    <p>Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].</p>
    Formula:C30H36N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.65

    Ref: TM-T79862

  • Mevociclib
    Targetmol
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    Mevociclib

    CAS:
    <p>Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.</p>
    Formula:C31H35ClN8O2
    Purity:98.02% - 98.02%
    Color and Shape:Solid
    Molecular weight:587.11

    Ref: TM-T13044

  • CymitQuimica logo
    Targetmol
    + Info

    Palbociclib orotate

    CAS:
    <p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>
    Formula:C29H33N9O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.63

    Ref: TM-T72507

  • KM05382
    Targetmol
    + Info

    KM05382

    CAS:
    <p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>
    Formula:C20H19ClN2O3S2
    Color and Shape:Solid
    Molecular weight:434.96

    Ref: TM-T27735

  • CDK4-IN-2
    Targetmol
    + Info

    CDK4-IN-2

    CAS:
    <p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>
    Formula:C22H26F2N6O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:508.54

    Ref: TM-T79046

  • DCB-3503
    Targetmol
    + Info

    DCB-3503

    CAS:
    <p>DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.</p>
    Formula:C24H27NO5
    Color and Shape:Solid
    Molecular weight:409.47

    Ref: TM-T27128

  • LDC3140
    Targetmol
    + Info

    LDC3140

    CAS:
    <p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>
    Formula:C23H33N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.55

    Ref: TM-T27805

  • Leucettinib-92
    Targetmol
    + Info

    Leucettinib-92

    CAS:
    <p>Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM</p>
    Formula:C21H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.49

    Ref: TM-T79562

  • CDK9-IN-9
    Targetmol
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    CDK9-IN-9

    CAS:
    <p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>
    Formula:C22H23F2N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.51

    Ref: TM-T10747

  • (2S,3R)-Voruciclib
    Targetmol
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    (2S,3R)-Voruciclib

    CAS:
    <p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>
    Formula:C22H19ClF3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.84

    Ref: TM-T10096

  • CDK9-IN-2
    Targetmol
    + Info

    CDK9-IN-2

    CAS:
    <p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>
    Formula:C23H25ClFN5
    Purity:99%
    Color and Shape:Solid
    Molecular weight:425.93

    Ref: TM-T14918

  • CDK7-IN-14
    Targetmol
    + Info

    CDK7-IN-14

    CAS:
    <p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>
    Formula:C22H24F3N6OP
    Color and Shape:Solid
    Molecular weight:476.43

    Ref: TM-T63108

  • 5-Iodo-indirubin-3'-monoxime
    Targetmol
    + Info

    5-Iodo-indirubin-3'-monoxime

    CAS:
    <p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>
    Formula:C16H10IN3O2
    Color and Shape:Solid
    Molecular weight:403.17

    Ref: TM-T10172

  • NU6300
    Targetmol
    + Info

    NU6300

    CAS:
    <p>NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.</p>
    Formula:C20H23N5O3S
    Purity:96.08%
    Color and Shape:Solid
    Molecular weight:413.49

    Ref: TM-T16360

  • Voruciclib hydrochloride
    Targetmol
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    Voruciclib hydrochloride

    CAS:
    <p>Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).</p>
    Formula:C22H20Cl2F3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.3

    Ref: TM-T13309

  • PF-6808472
    Targetmol
    + Info

    PF-6808472

    CAS:
    <p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>
    Formula:C25H27FN8O3S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:538.6

    Ref: TM-T33955

  • CDK7-IN-22
    Targetmol
    + Info

    CDK7-IN-22

    CAS:
    <p>CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].</p>
    Formula:C22H25F3N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47

    Ref: TM-T79169