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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • FMF-04-159-2
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    FMF-04-159-2

    CAS:
    <p>FMF-04-159-2 is a potent covalent CDK14 &amp; CDK2 inhibito and is able to reduce α-Syn aggregation in neurons, and inhibits TNBC cancer progression.</p>
    Formula:C28H30Cl3N7O5S
    Purity:96.57%
    Color and Shape:Solid
    Molecular weight:683.01

    Ref: TM-T11309

  • Ribociclib-d6
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    Ribociclib-d6

    CAS:
    <p>Ribociclib-d6 is a deuterated compound of Ribociclib (LEE011) for isotope tracing.Ribociclib is an orally available CDK4/6 inhibitor with antitumor activity.</p>
    Formula:C23H30N8O
    Color and Shape:Solid
    Molecular weight:440.57

    Ref: TM-TMID-0003

  • CDK9-IN-1
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    CDK9-IN-1

    CAS:
    <p>CDK9-IN-1 is a selective and potent CDK9 inhibitor with antiviral activity used in the study of PRRSV infections.</p>
    Formula:C26H21N5O4S
    Purity:98.52%
    Color and Shape:Solid
    Molecular weight:499.54

    Ref: TM-T10741

  • (E/Z)-Zotiraciclib hydrochloride
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    (E/Z)-Zotiraciclib hydrochloride

    CAS:
    <p>(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent inhibitor of CDK2, JAK2, and FLT3.</p>
    Formula:C23H25ClN4O
    Color and Shape:Solid
    Molecular weight:408.93

    Ref: TM-T62056

  • GP-82996
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    GP-82996

    CAS:
    <p>GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.</p>
    Formula:C27H32N6O
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:456.58

    Ref: TM-T21720

  • Palbociclib
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    Palbociclib

    CAS:
    <p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>
    Formula:C24H29N7O2
    Purity:98% - 99.9%
    Color and Shape:Solid
    Molecular weight:447.53

    Ref: TM-T1785

  • Atuveciclib
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    Atuveciclib

    CAS:
    <p>Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.</p>
    Formula:C18H18FN5O2S
    Purity:98.8%
    Color and Shape:Solid
    Molecular weight:387.43

    Ref: TM-T10464L

  • DRB
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    DRB

    CAS:
    <p>DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)</p>
    Formula:C12H12Cl2N2O4
    Purity:99.46% - 99.83%
    Color and Shape:White To Off-White Crystalline Solid
    Molecular weight:319.14

    Ref: TM-T7789

  • BS194
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    BS194

    CAS:
    <p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>
    Formula:C20H27N5O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:385.46

    Ref: TM-T7698

  • TC11
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    TC11

    CAS:
    <p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>
    Formula:C20H22N2O2
    Purity:97.86%
    Color and Shape:Solid
    Molecular weight:322.4

    Ref: TM-T9083

  • Cdk5 Substrate acetate
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    Cdk5 Substrate acetate

    <p>Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.</p>
    Formula:C55H103N15O14
    Purity:96.21%
    Color and Shape:Solid
    Molecular weight:1198.5

    Ref: TM-T37207L

  • AMG 925 HCl
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    AMG 925 HCl

    CAS:
    <p>AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).</p>
    Formula:C26H30ClN7O2
    Color and Shape:Solid
    Molecular weight:508.02

    Ref: TM-T63487

  • PF-06873600
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    PF-06873600

    CAS:
    <p>PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.</p>
    Formula:C20H27F2N5O4S
    Purity:98.77% - 99.55%
    Color and Shape:Solid
    Molecular weight:471.52

    Ref: TM-T8463

  • LY2857785
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    LY2857785

    CAS:
    <p>LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).</p>
    Formula:C26H36N6O
    Purity:99.68%
    Color and Shape:Solid Powder
    Molecular weight:448.6

    Ref: TM-TQ0060

  • CDK9-IN-30
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    CDK9-IN-30

    CAS:
    <p>CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.</p>
    Formula:C16H20FNO3
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:293.33

    Ref: TM-T9632

  • AZD-5438
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    AZD-5438

    CAS:
    <p>AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).</p>
    Formula:C18H21N5O2S
    Purity:99.73% - 99.87%
    Color and Shape:Solid
    Molecular weight:371.46

    Ref: TM-T2506

  • Flavopiridol hydrochloride
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    Flavopiridol hydrochloride

    CAS:
    <p>Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.</p>
    Formula:C21H21Cl2NO5
    Purity:98.87% - 99.88%
    Color and Shape:Solid
    Molecular weight:438.3

    Ref: TM-T2615

  • Seliciclib
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    Seliciclib

    CAS:
    <p>Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.</p>
    Formula:C19H26N6O
    Purity:97.15% - 99.89%
    Color and Shape:White To Off-White Solid
    Molecular weight:354.45

    Ref: TM-T2095

  • BSJ-03-123
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    BSJ-03-123

    CAS:
    <p>BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.</p>
    Formula:C47H56N10O11
    Purity:97.78% - 99.38%
    Color and Shape:Solid
    Molecular weight:937.01

    Ref: TM-T5395

  • (E/Z)-Zotiraciclib
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    (E/Z)-Zotiraciclib

    CAS:
    <p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>
    Formula:C23H24N4O
    Purity:97.75% - 99.92%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T21503