CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Found 546 products of "CDK"
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LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Formula:C16H12FN5OPurity:99.87%Color and Shape:SolidMolecular weight:309.3Ref: TM-T7810
1mg38.00€5mg80.00€10mg109.00€25mg212.00€50mg318.00€100mg477.00€200mg677.00€1mL*10mM (DMSO)87.00€LDC4297 hydrochloride
CAS:LDC4297 hydrochloride is a selective and potent CDK7 inhibitor with broad-spectrum antiviral activity, useful for research on viral infections.Formula:C23H29ClN8OColor and Shape:SolidMolecular weight:468.987BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.17BS-181 dihydrochloride
CAS:BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Formula:C22H34Cl2N6Color and Shape:SolidMolecular weight:453.46Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Formula:C27H32F2N8·CH4O3SPurity:98.69% - 99.44%Color and Shape:SolidMolecular weight:602.7NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Formula:C17H19Cl2N5O4SPurity:99.56% - 99.85%Color and Shape:SolidMolecular weight:460.33Ref: TM-TQ0068
1mg46.00€5mg92.00€10mg138.00€25mg255.00€50mg374.00€100mg533.00€200mg705.00€1mL*10mM (DMSO)94.00€HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Formula:C15H15N5OS2Purity:98.11%Color and Shape:SolidMolecular weight:345.44Ref: TM-T9849
1mg43.00€2mg56.00€5mg93.00€10mg144.00€25mg319.00€50mg537.00€100mg767.00€500mg1,558.00€1mL*10mM (DMSO)90.00€MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Formula:C17H18N4O3SPurity:99.84%Color and Shape:SolidMolecular weight:358.41Ref: TM-T5533
1mg52.00€5mg124.00€10mg177.00€25mg301.00€50mg424.00€100mg605.00€200mg797.00€1mL*10mM (DMSO)136.00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Formula:C4H3ClN2Purity:98.98% - 99.89%Color and Shape:Clear Colorless To Yellowish LiquidMolecular weight:114.53RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Formula:C21H20Cl2N10OPurity:98.09% - >99.99%Color and Shape:SolidMolecular weight:499.36LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Formula:C23H29ClN8OPurity:100%Color and Shape:SolidMolecular weight:469.02LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formula:C26H39N7O3Purity:99.66%Color and Shape:SolidMolecular weight:497.63FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formula:C17H18FN3SPurity:98.61%Color and Shape:SolidMolecular weight:315.41Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Formula:C16H11N3O2Purity:98.34%Color and Shape:SolidMolecular weight:277.28Ref: TM-T9138
1mg44.00€5mg93.00€10mg120.00€25mg236.00€50mg356.00€100mg532.00€200mg772.00€1mL*10mM (DMSO)92.00€Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Formula:C21H31N7OPurity:99.75%Color and Shape:SolidMolecular weight:397.52Ref: TM-TQ0053
1mg42.00€2mg55.00€5mg88.00€10mg145.00€25mg260.00€50mg414.00€100mg583.00€1mL*10mM (DMSO)87.00€MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Formula:C18H17ClN4OPurity:98.93%Color and Shape:SolidMolecular weight:340.81Ref: TM-TQ0266
1mg63.00€5mg137.00€10mg215.00€25mg462.00€50mg692.00€100mg964.00€1mL*10mM (DMSO)150.00€Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formula:C17H14N4Purity:99.74%Color and Shape:SolidMolecular weight:274.32Ref: TM-T5673
1mg34.00€5mg73.00€10mg94.00€25mg177.00€50mg323.00€100mg460.00€200mg622.00€1mL*10mM (DMSO)71.00€Aminopurvalanol A
CAS:Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Formula:C19H26ClN7OPurity:99.73%Color and Shape:SolidMolecular weight:403.91Ref: TM-T22260
2mg39.00€5mg60.00€10mg92.00€25mg173.00€50mg269.00€100mg389.00€200mg555.00€1mL*10mM (DMSO)62.00€KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formula:C16H27Cl2N5Purity:99.79%Color and Shape:SolidMolecular weight:360.33Ref: TM-T9446
1mg96.00€2mg143.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€1mL*10mM (DMSO)249.00€Amantadine
CAS:Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.Formula:C10H17NPurity:99.73% - 99.94%Color and Shape:Hexakistetrahedral Crystals By Sublimation SolidMolecular weight:151.25ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Formula:C24H27N7OPurity:99.53% - 99.7%Color and Shape:SolidMolecular weight:429.52Ribociclib
CAS:Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).Formula:C23H30N8OPurity:97.91% - >99.99%Color and Shape:SolidMolecular weight:434.54Ref: TM-T6199
2mg43.00€5mg64.00€10mg86.00€25mg97.00€50mg116.00€100mg168.00€500mg420.00€1mL*10mM (DMSO)69.00€PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Formula:C12H11N3OPurity:99.49% - >99.99%Color and Shape:SolidMolecular weight:213.24Ref: TM-T6206
2mg34.00€5mg49.00€10mg64.00€25mg92.00€50mg138.00€100mg197.00€200mg295.00€1mL*10mM (DMSO)50.00€Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormula:C15H10O5Purity:97.93%Color and Shape:SolidMolecular weight:270.24ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurity:98.27%Color and Shape:SolidMolecular weight:394.44Ref: TM-T16391
1mg48.00€5mg71.00€10mg100.00€25mg172.00€50mg268.00€100mg404.00€200mg570.00€1mL*10mM (DMSO)60.00€Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.
Formula:C25H30N6O2Purity:99.69%Color and Shape:SolidMolecular weight:446.54LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formula:C16H12FN5OColor and Shape:SolidMolecular weight:309.3SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purity:99.88%Color and Shape:SolidMolecular weight:376.25Ref: TM-T3700
1mg50.00€2mg66.00€5mg90.00€10mg146.00€25mg250.00€50mg403.00€100mg593.00€1mL*10mM (DMSO)108.00€CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:358.67Ref: TM-T19913
1mg73.00€5mg128.00€10mg185.00€25mg299.00€50mg405.00€100mg545.00€1mL*10mM (DMSO)140.00€BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Formula:C16H17N5Purity:90%Color and Shape:SolidMolecular weight:279.34Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.87%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg56.00€5mg109.00€10mg168.00€25mg284.00€50mg423.00€100mg610.00€1mL*10mM (DMSO)133.00€CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formula:C28H28N6O4Purity:98.66% - 98.8%Color and Shape:SolidMolecular weight:512.56Ref: TM-T4482
1mg50.00€5mg105.00€10mg170.00€25mg340.00€50mg512.00€100mg733.00€500mg1,513.00€1mL*10mM (DMSO)120.00€AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formula:C15H18BrN7Purity:96.69% - 99.6%Color and Shape:SolidMolecular weight:376.25MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formula:C21H19N3O2SPurity:98.80%Color and Shape:SolidMolecular weight:377.46Ref: TM-T22106
2mg34.00€5mg50.00€10mg86.00€25mg161.00€50mg245.00€100mg363.00€200mg515.00€1mL*10mM (DMSO)55.00€Purvalanol A
CAS:Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Formula:C19H25ClN6OPurity:98.13% - 99.68%Color and Shape:PowderMolecular weight:388.89NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Formula:C12H17N5OPurity:99.34% - 99.92%Color and Shape:SolidMolecular weight:247.3Ref: TM-T3186
10mg42.00€25mg78.00€50mg106.00€100mg160.00€200mg230.00€500mg378.00€1mL*10mM (DMSO)47.00€SNS-032
CAS:SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Formula:C17H24N4O2S2Purity:98.27% - 99.91%Color and Shape:SolidMolecular weight:380.53Ref: TM-T6049
5mg48.00€10mg63.00€25mg92.00€50mg124.00€100mg202.00€200mg299.00€500mg504.00€1mL*10mM (DMSO)50.00€PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Formula:C21H20F3N7O3SHClPurity:97.08%Color and Shape:SolidMolecular weight:543.95TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFormula:C20H22N2O2Purity:97.86%Color and Shape:SolidMolecular weight:322.4LY2857785
CAS:LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Formula:C26H36N6OPurity:99.68%Color and Shape:Solid PowderMolecular weight:448.6Ref: TM-TQ0060
1mg50.00€2mg71.00€5mg105.00€10mg170.00€25mg334.00€50mg537.00€100mg863.00€1mL*10mM (DMSO)117.00€SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormula:C15H19Br2ClN4Purity:98.13% - 98.47%Color and Shape:SolidMolecular weight:450.6Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Formula:C25H31ClN6O2Color and Shape:SolidMolecular weight:483.01AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Formula:C23H28FN7OPurity:98.01%Color and Shape:SolidMolecular weight:437.51AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurity:>99.99%Color and Shape:SolidMolecular weight:405.24Ref: TM-T8378
1mg124.00€2mg170.00€5mg260.00€10mg409.00€25mg677.00€50mg954.00€100mg1,288.00€1mL*10mM (DMSO)286.00€6-(Dimethylamino)purine
CAS:6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitorFormula:C7H9N5Purity:99.01% - 99.77%Color and Shape:SolidMolecular weight:163.18PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Formula:C12H12ClN3OPurity:99.56% - 99.92%Color and Shape:SolidMolecular weight:249.69LDC000067
CAS:LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.Formula:C18H18N4O3SPurity:98.08% - 99.07%Color and Shape:SolidMolecular weight:370.43AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Formula:C18H18Cl2F3N5O4Color and Shape:SolidMolecular weight:496.27
