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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 522 products of "CDK"

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  • Protein kinase inhibitor 11
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    Protein kinase inhibitor 11

    CAS:
    Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.
    Formula:C21H18FN5O2S
    Color and Shape:Solid
    Molecular weight:423.463

    Ref: TM-T205016

  • CTX-712
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    CTX-712

    CAS:
    <p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>
    Formula:C19H17FN8O2
    Color and Shape:Solid
    Molecular weight:408.39

    Ref: TM-T62049

  • CDK9-IN-38
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    CDK9-IN-38

    CAS:
    <p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>
    Formula:C22H23N5O3S
    Color and Shape:Solid
    Molecular weight:437.515

    Ref: TM-T206913

  • Cdc7-IN-19
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    Cdc7-IN-19

    CAS:
    Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].
    Formula:C19H21N5O2
    Color and Shape:Solid
    Molecular weight:351.40

    Ref: TM-T61223

  • PKMYT1-IN-7
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    PKMYT1-IN-7

    CAS:
    PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.
    Formula:C17H18FN5O3
    Color and Shape:Solid
    Molecular weight:359.355

    Ref: TM-T206777

  • P162-0948
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    P162-0948

    CAS:
    P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.
    Formula:C20H15FN4O2
    Color and Shape:Solid
    Molecular weight:362.357

    Ref: TM-T205592

  • CDK4/9-IN-1
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    CDK4/9-IN-1

    CAS:
    CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.
    Formula:C22H34N6O2
    Color and Shape:Solid
    Molecular weight:414.544

    Ref: TM-T205312

  • CDK2-IN-39
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    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Formula:C14H15N3O4S
    Color and Shape:Solid
    Molecular weight:321.352

    Ref: TM-T204890

  • CDK2-IN-40
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    CDK2-IN-40

    CAS:
    CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.
    Formula:C16H21N7O2
    Color and Shape:Solid
    Molecular weight:343.384

    Ref: TM-T205452

  • Zeltociclib
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    Zeltociclib

    CAS:
    Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.
    Formula:C18H20F3N4O2P
    Color and Shape:Solid
    Molecular weight:412.346

    Ref: TM-T205641

  • CDK4/6-IN-24
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    CDK4/6-IN-24

    CAS:
    CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.
    Formula:C32H41N7O3
    Color and Shape:Solid
    Molecular weight:571.713

    Ref: TM-T205628

  • LZ9
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    LZ9

    CAS:
    LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.
    Formula:C17H11F3N4O2
    Color and Shape:Solid
    Molecular weight:360.29

    Ref: TM-T204957

  • CDK2 degrader 4
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    CDK2 degrader 4

    CAS:
    CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.
    Formula:C23H26ClN3O5
    Color and Shape:Solid
    Molecular weight:459.923

    Ref: TM-T204856

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
    Formula:C25H31FN8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.57

    Ref: TM-T10737

  • CDK7-IN-26
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    CDK7-IN-26

    CAS:
    CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.
    Formula:C22H22FN6OPS
    Molecular weight:468.49

    Ref: TM-T208352

  • DDO-6079
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    DDO-6079

    CAS:
    DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.
    Formula:C18H13ClN2O3
    Color and Shape:Solid
    Molecular weight:340.76

    Ref: TM-T204112

  • GFB-12811
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    GFB-12811

    CAS:
    GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.
    Formula:C22H23F4N5O
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:449.44

    Ref: TM-T62695

  • LY3143921 hydrate
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    LY3143921 hydrate

    CAS:
    LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].
    Formula:C16H14FN5O2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:327.31

    Ref: TM-T9064

  • Tanuxiciclib
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    Tanuxiciclib

    CAS:
    Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.
    Formula:C15H13FN6O
    Color and Shape:Solid
    Molecular weight:312.308

    Ref: TM-T39404

    ne
    Discontinued
    Discontinued product
  • GSK-3/CDK5/CDK2-IN-1
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    GSK-3/CDK5/CDK2-IN-1

    CAS:
    GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
    Formula:C21H22N4O2
    Color and Shape:Solid
    Molecular weight:362.433

    Ref: TM-T35555

    ne
    Discontinued
    Discontinued product