PLK
PLK (Polo-like Kinase) inhibitors target PLKs, a family of serine/threonine kinases that are essential for various stages of cell division, including mitotic entry, spindle assembly, and cytokinesis. PLKs are critical for the proper execution of the cell cycle, and their dysregulation is often associated with cancer. Inhibiting PLKs can induce cell cycle arrest and apoptosis in cancer cells, making these inhibitors important tools in cancer research and therapy. At CymitQuimica, we offer a range of high-quality PLK inhibitors to support your research in mitosis, cell cycle control, and oncology.
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Centrinone
CAS:1798871-30-3
Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
Formula:
C26H25F2N7O6S2
Purity:
98.76%
Color and Shape:
Solid
Molecular weight:
633.65
Ref: TM-T14927
| 1mg | 60.00 € | ||
| 2mg | 83.00 € | ||
| 5mg | 115.00 € | ||
| 10mg | 183.00 € | ||
| 50mg | 426.00 € | ||
| 100mg | 625.00 € | ||
| 1mL*10mM (DMSO) | 164.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
3MB-PP1
CAS:956025-83-5
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.
Formula:
C17H21N5
Purity:
99.97%
Color and Shape:
White Solid
Molecular weight:
295.38
Ref: TM-T21678
| 5mg | 52.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 263.00 € | ||
| 100mg | 386.00 € | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.
Purity:
96.8%
Color and Shape:
Liquid
Molecular weight:
70.5 kDa (predicted); 66 kDa (reducing conditions)
Ref: TM-TMPY-04376
| 50µg | 326.00 € | ||
| 100µg | 546.00 € | ||
| 200µg | 933.00 € | ||
| 500µg | 1,827.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.
Color and Shape:
Solid
Molecular weight:
70.6 kDa (predicted); 65 kDa (reducing conditions)
Ref: TM-TMPY-04438
| 50µg | 498.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Poloxime
CAS:17302-61-3
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also …
Formula:
C10H13NO2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
179.22
Ref: TM-T16559
| 2mg | 46.00 € | ||
| 5mg | 67.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 135.00 € | ||
| 50mg | 172.00 € | ||
| 100mg | 278.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
![5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE](https://static.cymitquimica.com/products/TM/thumb/T8912.jpg)
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:17899-49-9
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.
Formula:
C8H13N3S
Purity:
99.03%
Color and Shape:
Solid
Molecular weight:
183.27
Ref: TM-T8912
| 5mg | 36.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 91.00 € | ||
| 50mg | 116.00 € | ||
| 100mg | 168.00 € | ||
| 200mg | 249.00 € | ||
| 1mL*10mM (DMSO) | 40.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
HMN-214
CAS:173529-46-9
HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
Formula:
C22H20N2O5S
Purity:
100% - 98.63%
Color and Shape:
Solid
Molecular weight:
424.47
Ref: TM-T2438
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 84.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 216.00 € | ||
| 50mg | 347.00 € | ||
| 100mg | 498.00 € | ||
| 500mg | 1,096.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ocifisertib(CFI-400945 free base)
CAS:1338806-73-7
Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase …
Formula:
C33H34N4O3
Purity:
97.56% - 98.53%
Color and Shape:
Solid
Molecular weight:
534.65
Ref: TM-T7384
| 1mg | 44.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 273.00 € | ||
| 50mg | 475.00 € | ||
| 100mg | 756.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ro3280
CAS:1062243-51-9
Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
Formula:
C27H35F2N7O3
Purity:
100% - 98%
Color and Shape:
Solid
Molecular weight:
543.61
Ref: TM-T2634
| 1mg | 65.00 € | ||
| 5mg | 146.00 € | ||
| 10mg | 190.00 € | ||
| 25mg | 406.00 € | ||
| 50mg | 602.00 € | ||
| 100mg | 837.00 € | ||
| 1mL*10mM (DMSO) | 183.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TAK-960
CAS:1137868-52-0
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, …
Formula:
C27H34F3N7O3
Purity:
97.06%
Color and Shape:
Solid
Molecular weight:
561.6
Ref: TM-T7200
| 1mg | 63.00 € | ||
| 2mg | 88.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 288.00 € | ||
| 50mg | 479.00 € | ||
| 100mg | 694.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GSK461364
CAS:929095-18-1
GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than …
Formula:
C27H28F3N5O2S
Purity:
98.85% - 99.5%
Color and Shape:
Solid
Molecular weight:
543.6
Ref: TM-T6282
| 1mg | 37.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 121.00 € | ||
| 25mg | 202.00 € | ||
| 50mg | 365.00 € | ||
| 100mg | 549.00 € | ||
| 200mg | 779.00 € | ||
| 500mg | 1,189.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LFM-A13
CAS:244240-24-2
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other …
Formula:
C11H8Br2N2O2
Purity:
99.9%
Color and Shape:
Solid
Molecular weight:
360
Ref: TM-T6217
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 95.00 € | ||
| 50mg | 161.00 € | ||
| 100mg | 263.00 € | ||
| 200mg | 383.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Poloxin
CAS:321688-88-4
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: …
Formula:
C18H19NO3
Purity:
99.19%
Color and Shape:
Solid
Molecular weight:
297.35
Ref: TM-T16560
| 5mg | 38.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 96.00 € | ||
| 50mg | 159.00 € | ||
| 100mg | 228.00 € | ||
| 200mg | 337.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
(E/Z)-Rigosertib sodium
CAS:1225497-78-8
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay).
Formula:
C21H24NNaO8S
Purity:
97.16% - 99.82%
Color and Shape:
Solid
Molecular weight:
473.47
Ref: TM-T6070
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 339.00 € | ||
| 100mg | 580.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MLN0905
CAS:1228960-69-7
MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).
Formula:
C24H25F3N6S
Purity:
97.17% - 98%
Color and Shape:
Solid
Molecular weight:
486.56
Ref: TM-T2704
| 1mg | 60.00 € | ||
| 5mg | 126.00 € | ||
| 10mg | 186.00 € | ||
| 25mg | 347.00 € | ||
| 50mg | 521.00 € | ||
| 1mL*10mM (DMSO) | 134.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
(1E)-CFI-400437 dihydrochloride
CAS:1247000-76-5
(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
Formula:
C29H30Cl2N6O2
Purity:
98.36%
Color and Shape:
Solid
Molecular weight:
565.5
Ref: TM-T22288
| 1mg | 86.00 € | ||
| 5mg | 166.00 € | ||
| 10mg | 245.00 € | ||
| 25mg | 401.00 € | ||
| 50mg | 560.00 € | ||
| 100mg | 794.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
HMN-176
CAS:173529-10-7
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
Formula:
C20H18N2O4S
Purity:
98.92% - 98.99%
Color and Shape:
Solid
Molecular weight:
382.43
Ref: TM-T3643
| 1mg | 42.00 € | ||
| 2mg | 56.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 186.00 € | ||
| 50mg | 347.00 € | ||
| 100mg | 515.00 € | ||
| 500mg | 1,110.00 € | ||
| 1mL*10mM (DMSO) | 78.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Cyclapolin 9
CAS:40533-25-3
Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.
Formula:
C9H4F3N3O4S
Purity:
99.5%
Color and Shape:
Solid
Molecular weight:
307.21
Ref: TM-T22700
| 1mg | 90.00 € | ||
| 5mg | 212.00 € | ||
| 10mg | 331.00 € | ||
| 25mg | 529.00 € | ||
| 50mg | 731.00 € | ||
| 100mg | 995.00 € | ||
| 500mg | 1,999.00 € | ||
| 1mL*10mM (DMSO) | 239.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Centrinone-B
CAS:1798871-31-4
Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative …
Formula:
C27H27F2N7O5S2
Purity:
98.71%
Color and Shape:
Solid
Molecular weight:
631.67
Ref: TM-T14926
| 2mg | 186.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
TC-S 7005
CAS:1082739-92-1
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and …
Formula:
C21H17N3O3
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
359.38
Ref: TM-T17008
| 1mg | 56.00 € | ||
| 2mg | 82.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 347.00 € | ||
| 50mg | 519.00 € | ||
| 100mg | 697.00 € | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 138.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
