PLK
PLK (Polo-like Kinase) inhibitors target PLKs, a family of serine/threonine kinases that are essential for various stages of cell division, including mitotic entry, spindle assembly, and cytokinesis. PLKs are critical for the proper execution of the cell cycle, and their dysregulation is often associated with cancer. Inhibiting PLKs can induce cell cycle arrest and apoptosis in cancer cells, making these inhibitors important tools in cancer research and therapy. At CymitQuimica, we offer a range of high-quality PLK inhibitors to support your research in mitosis, cell cycle control, and oncology.
Found 25 products of "PLK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
SP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Formula:C40H40F2N12O5Purity:98%Color and Shape:SolidMolecular weight:806.82RP-1664
CAS:RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Formula:C23H24F2N8O2SPurity:99.04%Color and Shape:SoildMolecular weight:514.55PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Color and Shape:Odour SolidPLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Color and Shape:Odour SolidPLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS:Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.Formula:C10H13NO2Purity:98%Color and Shape:SolidMolecular weight:179.22PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Purity:96.8%Color and Shape:Lyophilized PowderMolecular weight:70.5 kDa (predicted); 66 kDa (reducing conditions)5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formula:C8H13N3SPurity:99.03%Color and Shape:SolidMolecular weight:183.27MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurity:98% - 99.92%Color and Shape:SolidMolecular weight:486.56GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurity:99% - 99.73%Color and Shape:SolidMolecular weight:543.6Ref: TM-T6282
1mg34.00€2mg49.00€5mg71.00€10mg117.00€25mg195.00€50mg354.00€100mg528.00€200mg755.00€500mg1,153.00€HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formula:C20H18N2O4SPurity:98.92% - 98.99%Color and Shape:SolidMolecular weight:382.43Ref: TM-T3643
1mg43.00€2mg56.00€5mg88.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)79.00€(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formula:C29H30Cl2N6O2Purity:97.08%Color and Shape:SolidMolecular weight:565.5Ref: TM-T22288
1mg77.00€5mg160.00€10mg236.00€25mg394.00€50mg550.00€100mg782.00€1mL*10mM (DMSO)197.00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formula:C18H19NO3Purity:99.19%Color and Shape:SolidMolecular weight:297.35HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formula:C22H20N2O5SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:424.47Ref: TM-T2438
1mg38.00€2mg50.00€5mg80.00€10mg117.00€25mg207.00€50mg333.00€100mg477.00€500mg1,063.00€1mL*10mM (DMSO)87.00€TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Formula:C27H34F3N7O3Purity:97.06%Color and Shape:SolidMolecular weight:561.6Ref: TM-T7200
1mg60.00€2mg85.00€5mg114.00€10mg161.00€25mg279.00€50mg464.00€100mg672.00€1mL*10mM (DMSO)161.00€Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purity:97.1% - >99.99%Color and Shape:SolidMolecular weight:543.61Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purity:98.71%Color and Shape:SolidMolecular weight:631.67Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formula:C9H4F3N3O4SPurity:99.64%Color and Shape:SolidMolecular weight:307.21Ref: TM-T22700
1mg96.00€5mg205.00€10mg319.00€25mg512.00€50mg707.00€100mg964.00€500mg1,935.00€1mL*10mM (DMSO)227.00€Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formula:C16H15NO3Purity:99.67%Color and Shape:SolidMolecular weight:269.3TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purity:99.516%Color and Shape:SolidMolecular weight:359.38Ref: TM-T17008
1mg57.00€2mg84.00€5mg125.00€10mg188.00€25mg354.00€50mg532.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)138.00€
![5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8912.webp&w=3840&q=75)
