DYRK
DYRK (Dual-specificity Tyrosine Phosphorylation-regulated Kinase) inhibitors are compounds that target the DYRK family of kinases, which are involved in cell cycle regulation, neuronal development, and apoptosis. DYRK kinases have dual specificity, meaning they can phosphorylate both tyrosine and serine/threonine residues. Inhibiting DYRK kinases can affect various cellular processes, including cell cycle progression and differentiation. DYRK inhibitors are important tools in research on cancer, neurodegenerative diseases, and cell signaling. At CymitQuimica, we offer a selection of high-quality DYRK inhibitors to support your research in cell cycle control, neurobiology, and therapeutic development.
Found 47 products of "DYRK"
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BT173
CAS:BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.Formula:C18H12BrN3O2Purity:98.247%Color and Shape:SolidMolecular weight:382.21GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Formula:C18H10Cl2N4OSPurity:98.27%Color and Shape:SolidMolecular weight:401.27AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Formula:C19H16N4Purity:99.91%Color and Shape:SolidMolecular weight:300.36Ref: TM-T14364
1mg44.00€5mg92.00€10mg147.00€25mg289.00€50mg419.00€100mg583.00€200mg787.00€1mL*10mM (DMSO)100.00€DYR684
CAS:DYR684 is a PROTAC designed to target the protein kinase DYRK1A, promoting its rapid, efficient, potent, and selective degradation in cellular assays.Formula:C58H58FN15O5Color and Shape:SolidMolecular weight:1064.18GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Formula:C24H30N6O2Purity:98.51%Color and Shape:SolidMolecular weight:434.53Ref: TM-T40187
1mg123.00€5mg295.00€10mg447.00€25mg745.00€50mg1,108.00€100mg1,558.00€1mL*10mM (DMSO)339.00€Protein kinase inhibitors 1 hydrochloride
CAS:Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,Formula:C18H18ClN5O3SColor and Shape:SolidMolecular weight:419.88Mirk-IN-1
CAS:Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).Formula:C23H17Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:498.32Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Formula:C18H17N5O3SPurity:98%Color and Shape:SolidMolecular weight:383.42Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Formula:C13H12N2OPurity:98.29% - 99.92%Color and Shape:Off-White SolidMolecular weight:212.25LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Formula:C18H22Cl2N2O2SPurity:98%Color and Shape:SolidMolecular weight:401.35LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Formula:C18H20N2O2SPurity:99.01% - 99.51%Color and Shape:SolidMolecular weight:328.43Ref: TM-TQ0111
1mg49.00€2mg64.00€5mg92.00€10mg152.00€25mg295.00€50mg477.00€100mg763.00€200mg1,018.00€1mL*10mM (DMSO)104.00€GNF2133 hydrochloride
CAS:GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Formula:C24H31ClN6O2Color and Shape:SolidMolecular weight:471.02-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Formula:C6H6N4OPurity:99.21% - 99.42%Color and Shape:SolidMolecular weight:150.14AZ191
CAS:AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.Formula:C24H27N7OPurity:98.04% - 99.65%Color and Shape:SolidMolecular weight:429.52ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
Formula:C19H17N3O3Purity:99.82% - >99.99%Color and Shape:SolidMolecular weight:335.36GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Formula:C25H27FN6O4Purity:98.68% - 99.40%Color and Shape:SolidMolecular weight:494.52Harmine hydrochloride
CAS:Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.Formula:C13H13ClN2OPurity:99.61% - >99.99%Color and Shape:Yellow To Slightly Green Crystalline PowderMolecular weight:248.71ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Formula:C16H14N2O4Purity:99.32%Color and Shape:SolidMolecular weight:298.29DYRKi
CAS:DYRKi is a nontoxic, DYRK1-selective inhibitor.Formula:C20H13F3N4O2SColor and Shape:SolidMolecular weight:430.4Dyrk1A-IN-3
CAS:Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.Formula:C18H16N6Color and Shape:SolidMolecular weight:316.36tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Formula:C11H3Br4N3O2Purity:98%Color and Shape:SolidMolecular weight:528.78AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFormula:C15H13N3OPurity:99.99%Color and Shape:SolidMolecular weight:251.28FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Formula:C16H17NO2S2SiColor and Shape:SolidMolecular weight:347.53JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Formula:C21H17F3N8OColor and Shape:SolidMolecular weight:454.41Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Formula:C16H9IN2O2Color and Shape:SolidMolecular weight:388.16LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Formula:C17H19Cl3N2OSColor and Shape:SolidMolecular weight:405.77CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Formula:C28H30N6O2Purity:99.61%Color and Shape:SolidMolecular weight:482.58Ref: TM-T14980
1mg47.00€2mg62.00€5mg92.00€10mg160.00€25mg289.00€50mg505.00€100mg787.00€200mg1,063.00€ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Formula:C14H15NO3SPurity:97.19%Color and Shape:SolidMolecular weight:277.34ARN25068
CAS:ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Formula:C19H18N6SPurity:99.75%Color and Shape:SolidMolecular weight:362.45INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Formula:C12H13NO2SPurity:99.26%Color and Shape:SolidMolecular weight:235.3YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Formula:C25H27FN8OSPurity:98.61% - 99.64%Color and Shape:SolidMolecular weight:506.6DYRKs-IN-2
CAS:DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Formula:C32H38ClN9O3Purity:98%Color and Shape:SolidMolecular weight:632.16Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Formula:C22H16FN3O2SColor and Shape:SolidMolecular weight:405.445Norharmine
CAS:Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.Formula:C12H10N2OColor and Shape:SolidMolecular weight:198.221DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Formula:C23H24FN7Color and Shape:SolidMolecular weight:417.48Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Formula:C23H23F5N8OColor and Shape:SolidMolecular weight:522.47Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formula:C14H13F3N6Color and Shape:SolidMolecular weight:322.29DYRKs-IN-1 hydrochloride
CAS:DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formula:C30H31Cl2N7O4Color and Shape:SolidMolecular weight:624.52DYRKs-IN-1
CAS:DYRKs-IN-1 has antitumor activity.
Formula:C30H30ClN7O4Purity:98%Color and Shape:SolidMolecular weight:588.06Dyrk1A/α-synuclein-IN-2
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).Formula:C21H16N4O4SColor and Shape:SolidMolecular weight:420.44Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Formula:C27H32N6O4Color and Shape:SolidMolecular weight:504.58Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Formula:C20H21N5O3SColor and Shape:SolidMolecular weight:411.48DYRK1-IN-1
CAS:DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formula:C12H12N6Color and Shape:SolidMolecular weight:240.26Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Formula:C21H17N3O2S2Color and Shape:SolidMolecular weight:407.51Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.Formula:C23H20N4O3SColor and Shape:SolidMolecular weight:432.49Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formula:C17H21N3OColor and Shape:SolidMolecular weight:283.37
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