PKC
PKC (Protein Kinase C) inhibitors target the PKC family of serine/threonine kinases, which are involved in a wide range of cellular processes, including cell cycle regulation, apoptosis, and differentiation. PKC plays a key role in signal transduction pathways that influence cell proliferation and survival. Inhibiting PKC can lead to changes in cell cycle progression, making these inhibitors valuable in research related to cancer, neurobiology, and cardiovascular diseases. At CymitQuimica, we provide a diverse selection of high-quality PKC inhibitors to support your research in signal transduction, cell cycle regulation, and therapeutic development.
Found 124 products of "PKC"
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Ingenol
CAS:Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.
Formula:C20H28O5Purity:99.78% - 99.87%Color and Shape:SolidMolecular weight:348.43PKCβ inhibitor 1
CAS:PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Formula:C24H21N5O2Purity:99.33%Color and Shape:SolidMolecular weight:411.46Ref: TM-T8376
1mg93.00€5mg255.00€10mg363.00€25mg552.00€50mg730.00€100mg998.00€500µg58.00€1mL*10mM (DMSO)225.00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formula:C69H122N26O18Purity:>99.99%Color and Shape:SolidMolecular weight:1603.9Hypericin
CAS:Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.Formula:C30H16O8Purity:98.90% - ≥98%Color and Shape:Red-Coloured Anthraquinone-DerivativeMolecular weight:504.44Ref: TM-T6S0923
1mg54.00€5mg120.00€10mg172.00€25mg341.00€50mg504.00€100mg705.00€500mg1,431.00€1mL*10mM (DMSO)133.00€Enzastaurin
CAS:Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.Formula:C32H29N5O2Purity:98% - >99.99%Color and Shape:SolidMolecular weight:515.6Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formula:C28H28N4O3·HClPurity:99.14% - 99.28%Color and Shape:SolidMolecular weight:505.01Ref: TM-T3689
1mg67.00€2mg87.00€5mg148.00€10mg244.00€25mg487.00€50mg702.00€100mg982.00€500mg1,963.00€1mL*10mM (DMSO)190.00€Ionomycin calcium
CAS:Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.
Formula:C41H70CaO9Purity:98% - 98.11%Color and Shape:SolidMolecular weight:747.07Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formula:C28H40O8Purity:99.32% - 99.37%Color and Shape:SolidMolecular weight:504.61Ref: TM-T16526
1mg58.00€5mg160.00€10mg268.00€25mg530.00€50mg827.00€100mg1,314.00€200mg1,773.00€1mL*10mM (DMSO)170.00€CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Formula:C18H18ClN5OPurity:98.81%Color and Shape:SolidMolecular weight:355.82Ref: TM-T14943
1mg34.00€2mg46.00€5mg71.00€10mg92.00€25mg177.00€50mg314.00€100mg518.00€1mL*10mM (DMSO)78.00€AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFormula:C22H38O5Purity:98%Color and Shape:SolidMolecular weight:382.53PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Formula:C23H19ClO2Purity:98%Color and Shape:SolidMolecular weight:362.85SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formula:C17H22ClNO2SPurity:99.24% - 99.58%Color and Shape:SolidMolecular weight:339.88DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFormula:C21H38O2Purity:99.80%Color and Shape:SolidMolecular weight:322.53Ref: TM-T10980
1mg62.00€5mg126.00€10mg172.00€25mg350.00€50mg572.00€100mg772.00€200mg1,054.00€1mL*10mM (DMSO)138.00€CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formula:C24H27Cl2N5SPurity:99.63%Color and Shape:SolidMolecular weight:488.48Ref: TM-T10888
1mg57.00€5mg122.00€10mg192.00€25mg324.00€50mg459.00€100mg642.00€200mg888.00€1mL*10mM (DMSO)146.00€NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formula:C17H12Br2N2O3Purity:99.29% - 99.29%Color and Shape:SolidMolecular weight:452.1PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formula:C17H15F3N4OPurity:98%Color and Shape:SolidMolecular weight:348.32(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formula:C17H23N3O2Purity:98%Color and Shape:SolidMolecular weight:301.38TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formula:C20H24ClFN6OPurity:99.84%Color and Shape:SolidMolecular weight:418.9Ref: TM-T13314
1mg93.00€2mg125.00€5mg244.00€10mg364.00€25mg562.00€50mg780.00€100mg1,035.00€1mL*10mM (DMSO)225.00€PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formula:C25H37FN8O2Purity:98% - 98.79%Color and Shape:SolidMolecular weight:500.61PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Formula:C24H23N5O2Color and Shape:SolidMolecular weight:413.47AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formula:C30H41N7OSPurity:98%Color and Shape:SolidMolecular weight:547.76YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Formula:C19H20N2O3SColor and Shape:SolidMolecular weight:356.44Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51
