
HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 169 products of "HSP"
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KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Formula:C30H42N2O9Purity:98.68% - 99.52%Color and Shape:SolidMolecular weight:574.66Alvespimycin
CAS:<p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>Formula:C32H48N4O8Purity:99.88%Color and Shape:SolidMolecular weight:616.75Calenduloside E
CAS:<p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>Formula:C36H56O9Purity:96.16% - 98.99%Color and Shape:SolidMolecular weight:632.8217-AEP-GA
CAS:<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Formula:C34H50N4O8Purity:97.77% - 99.56%Color and Shape:SolidMolecular weight:642.78Retaspimycin Hydrochloride
CAS:<p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>Formula:C31H46ClN3O8Purity:98%Color and Shape:SolidMolecular weight:624.17Bimoclomol
CAS:<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Formula:C14H20ClN3O2Color and Shape:SolidMolecular weight:297.78CH5138303
CAS:<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Formula:C19H18ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:415.9AMP-PCP
CAS:<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Formula:C11H18N5O12P3Purity:98%Color and Shape:SolidMolecular weight:505.21JG-48
CAS:<p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>Formula:C20H16F3N3OS2Color and Shape:SolidMolecular weight:435.49Hsp90-IN-15
CAS:<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Formula:C23H27F3N4Color and Shape:SolidMolecular weight:416.48CCT251236
CAS:<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Formula:C32H32N4O5Purity:98.82% - 99.89%Color and Shape:SolidMolecular weight:552.62HSP90-IN-12
CAS:<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Formula:C25H36O4Color and Shape:SolidMolecular weight:400.55YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Formula:C27H27N3O4S3Color and Shape:SolidMolecular weight:553.72Displurigen
CAS:<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Formula:C15H10O4SPurity:98%Color and Shape:SolidMolecular weight:286.3Malonganenone A
CAS:<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Formula:C26H38N4O2Color and Shape:SolidMolecular weight:438.616BrCaQ
CAS:<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Formula:C18H15BrN2O3Color and Shape:SolidMolecular weight:387.23HSP90-IN-22
CAS:<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Formula:C25H30N4O3Purity:98%Color and Shape:SolidMolecular weight:434.53PU3
CAS:<p>PU3 is an inhibitor of Hsp90.</p>Formula:C19H25N5O3Purity:98%Color and Shape:SolidMolecular weight:371.43SEW84
CAS:<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Formula:C19H14F4N4OSColor and Shape:SolidMolecular weight:422.4HSP90-IN-14
CAS:<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Formula:C14H8Cl2N4O4SColor and Shape:SolidMolecular weight:399.21CH5164840
CAS:<p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>Formula:C19H23N5O2SColor and Shape:SolidMolecular weight:385.48Hsp90-Cdc37-IN-1
CAS:<p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>Formula:C43H57FN2O6SPurity:98%Color and Shape:SolidMolecular weight:748.99Vibsanin A
CAS:<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57YM-1
CAS:<p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>Formula:C20H20ClN3OS2Color and Shape:SolidMolecular weight:417.98BIIB028
CAS:<p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>Formula:C19H21ClN5O5PColor and Shape:SolidMolecular weight:465.83Retaspimycin
CAS:<p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>Formula:C31H45N3O8Purity:98%Color and Shape:SolidMolecular weight:587.7KUNB31
CAS:<p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>Formula:C19H18N2O3Color and Shape:SolidMolecular weight:322.36HSP90-IN-20
CAS:<p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>Formula:C26H32N4O4Color and Shape:SolidMolecular weight:464.56Hsp90-IN-17
CAS:<p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>Formula:C21H20N4O7Color and Shape:SolidMolecular weight:440.41Heat Shock Protein Inhibitor II
CAS:<p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>Formula:C12H11NO3Color and Shape:SolidMolecular weight:217.22SW02
CAS:<p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>Formula:C19H23BrN2O5Color and Shape:SolidMolecular weight:439.3PU24FCl
CAS:<p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>Formula:C20H21ClFN5O3Color and Shape:SolidMolecular weight:433.86BMS-358233
CAS:<p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>Formula:C25H25ClN6O2SColor and Shape:SolidMolecular weight:509.02EC 144
CAS:<p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9MPC-3100
CAS:<p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>Formula:C22H25BrN6O4SColor and Shape:SolidMolecular weight:549.44Iroxanadine
CAS:<p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>Formula:C14H20N4OPurity:98.04% - 99.04%Color and Shape:SolidMolecular weight:260.33AMP-PCP disodium
CAS:<p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>Formula:C11H16N5Na2O12P3Purity:99.32%Color and Shape:SolidMolecular weight:549.17SNX0723
CAS:<p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>Formula:C22H26FN3O3Purity:99.85%Color and Shape:SolidMolecular weight:399.46Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78JG-231
CAS:<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Formula:C22H18BrCl2N3OS4Purity:99.79%Color and Shape:SolidMolecular weight:619.47KU-177
CAS:<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Formula:C27H23NO8Purity:96.92% - 98.54%Color and Shape:SolidMolecular weight:489.47HSP90-IN-29
CAS:<p>HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].</p>Formula:C19H20ClN3O4Color and Shape:SolidMolecular weight:389.83GRP78-IN-2
CAS:<p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>Formula:C29H29NO6Color and Shape:SolidMolecular weight:487.54HSP90-IN-27
CAS:<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Formula:C18H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:343.44Flavokawain 1i
CAS:<p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>Formula:C21H18O4Color and Shape:SolidMolecular weight:334.37MAO A/HSP90-IN-2
CAS:<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Formula:C25H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:458.98HSP70/SIRT2-IN-2
CAS:<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5Colletofragarone A2
CAS:<p>Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.</p>Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44YM-08
CAS:<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49HSP90-IN-19
CAS:<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Formula:C29H38O7Purity:98%Color and Shape:SolidMolecular weight:498.61MAO A/HSP90-IN-1
CAS:<p>MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.</p>Formula:C24H29ClN2O4Purity:98%Color and Shape:SolidMolecular weight:444.95Iroxanadine sulfate
CAS:<p>Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.</p>Formula:C14H22N4O5SColor and Shape:SolidMolecular weight:358.41BX-2819
CAS:<p>BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .</p>Formula:C21H24N4O4SPurity:98%Color and Shape:SolidMolecular weight:428.51EV206
CAS:<p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40DDO-6691
CAS:<p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>Formula:C22H17N3O2SColor and Shape:SolidMolecular weight:387.45Onalespib lactate
CAS:<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Formula:C27H37N3O6Color and Shape:SolidMolecular weight:499.6Cemdomespib
CAS:<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5Hsp90-IN-37
CAS:<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.266ETB
CAS:<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Formula:C24H33NO6Molecular weight:431.52Hsp110-STAT3 interaction-IN-1
CAS:<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50KUNG65
CAS:<p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85KU-32
CAS:<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Formula:C20H25NO8Purity:98%Color and Shape:SolidMolecular weight:407.41Macbecin I
CAS:<p>Hsp90 inhibitor</p>Formula:C30H42N2O8Purity:98%Color and Shape:SolidMolecular weight:558.66C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53Hsp90-IN-34
CAS:<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38HSP90-IN-11
<p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54HSP90-IN-32
CAS:<p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68HSP90α-IN-1
CAS:<p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.356

