Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2611 products of "Chromatin/Epigenetics"
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HDAC-IN-38
CAS:HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.Formula:C27H28ClN3O2Color and Shape:SolidMolecular weight:461.98JG-2016
CAS:JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formula:C18H21ClN4O3Purity:99.00% - 99.37%Color and Shape:SolidMolecular weight:376.84Ref: TM-T82008
1mg110.00€5mg268.00€10mg432.00€25mg858.00€50mg1,378.00€100mg1,783.00€1mL*10mM (DMSO)294.00€XDM-CBP
CAS:XDM-CBP is an effective and selective CBP/p300 bromodomain inhibitor.Formula:C21H22N2O4Purity:98%Color and Shape:SolidMolecular weight:366.41JAK kinase-IN-1
CAS:JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formula:C17H19F2N7OSPurity:98%Color and Shape:SolidMolecular weight:407.44Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formula:C28H28N4O2Purity:98%Color and Shape:SolidMolecular weight:452.55EZH2-IN-14
CAS:EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formula:C31H39N7O2Color and Shape:SolidMolecular weight:541.69ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formula:C22H23F2N7OSPurity:98%Color and Shape:SolidMolecular weight:471.53JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46BET-IN-9
CAS:BET-IN-9 is a BET inhibitor[1].Formula:C22H24N4O3Color and Shape:SolidMolecular weight:392.45FHT-1204
CAS:FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Formula:C24H23N5O5S2Color and Shape:SolidMolecular weight:525.6PHD2/HDACs-IN-1
CAS:PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.Formula:C18H19N9O4Color and Shape:SolidMolecular weight:425.4MPI_5a
CAS:MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).Formula:C16H17N3O3Purity:99.62%Color and Shape:SolidMolecular weight:299.32Ref: TM-T16129
1mg250.00€2mg400.00€5mg755.00€10mg1,018.00€25mg1,504.00€50mg2,035.00€100mg2,673.00€1mL*10mM (DMSO)650.00€(S)-Ro 32-0432
CAS:(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].Formula:C28H29ClN4O2Color and Shape:SolidMolecular weight:489.01BRD-IN-3
CAS:BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.Formula:C21H25N5O3Purity:98%Color and Shape:SolidMolecular weight:395.45KDM5-C70
CAS:KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formula:C17H28N4O3Purity:97.63% - 99.86%Color and Shape:SolidMolecular weight:336.43Ref: TM-T15648
2mg42.00€5mg58.00€10mg84.00€25mg133.00€50mg233.00€100mg464.00€200mg663.00€500mg1,018.00€1mL*10mM (DMSO)70.00€NT160
CAS:NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.Formula:C21H21F3N4O2Purity:99.3%Color and Shape:SolidMolecular weight:418.41Ref: TM-T78709
1mg94.00€5mg222.00€10mg356.00€25mg715.00€50mg1,153.00€100mg1,783.00€1mL*10mM (DMSO)245.00€SP-2-225
CAS:SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formula:C28H34N2O3Purity:98%Color and Shape:SolidMolecular weight:446.58MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formula:C18H18ClF2N5OSPurity:98%Color and Shape:SolidMolecular weight:425.88KF21213
CAS:KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.Formula:C19H22N4O3Purity:98%Color and Shape:SolidMolecular weight:354.4KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formula:C25H26N6OPurity:98%Color and Shape:SolidMolecular weight:426.51QC6352
CAS:QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purity:99.1%Color and Shape:SolidMolecular weight:331.37A1B11
CAS:A1B11 is a selective SIRT2 inhibitor.Formula:C22H25N5OColor and Shape:SolidMolecular weight:375.47GNE-049
CAS:GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.Formula:C27H32F2N6O2Purity:98.67%Color and Shape:SolidMolecular weight:510.58TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Formula:C13H13BrN2OSPurity:99.751%Color and Shape:SolidMolecular weight:325.22Ref: TM-T13411
1mg93.00€5mg177.00€10mg269.00€25mg429.00€50mg610.00€100mg820.00€200mg1,071.00€1mL*10mM (DMSO)178.00€TNKS1/2-IN-1
CAS:TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Formula:C26H23F4N3O4Color and Shape:SolidMolecular weight:517.47SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97HIF-2α-IN-13
CAS:HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.Formula:C15H14ClF4NO2Color and Shape:SolidMolecular weight:351.72GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurity:98%Color and Shape:SolidMolecular weight:416.48HDAC8-IN-4
CAS:HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].Formula:C17H14N2O2S2Purity:98%Color and Shape:SolidMolecular weight:342.44Sirt2-IN-5
CAS:Sirt2-IN-5 is a potent inhibitor of SIRT2.Formula:C26H27Cl2N5O3Color and Shape:SolidMolecular weight:528.43TC-AC28
CAS:TC-AC28 is a novel potent and selective Brd2(2) ligand.Formula:C23H21N5O3Purity:98%Color and Shape:SolidMolecular weight:415.44SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurity:98%Color and Shape:SolidMolecular weight:673.73GSK4028
CAS:GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Formula:C17H21BrN4OColor and Shape:SolidMolecular weight:377.28Prolyl Hydroxylase inhibitor 1
CAS:Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).Formula:C19H18ClN5O4Purity:98%Color and Shape:SolidMolecular weight:415.83PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purity:98.59%Color and Shape:SolidMolecular weight:474.56Ref: TM-T12474
1mg117.00€5mg281.00€10mgTo inquire25mg858.00€50mg1,341.00€100mg2,125.00€1mL*10mM (DMSO)To inquireZINC08792355
CAS:ZINC08792355 is a novel inhibitor of SIRT1.Formula:C31H24N4O3Color and Shape:SolidMolecular weight:500.55HDAC/BET-IN-1
CAS:HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.Formula:C29H40N4O8SPurity:98%Color and Shape:SolidMolecular weight:604.71BRD7-IN-1
CAS:BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Formula:C22H28Cl2N4O3Purity:98.95%Color and Shape:SolidMolecular weight:467.39Ref: TM-T17697
1mg94.00€2mg137.00€5mg222.00€10mg334.00€25mg602.00€50mg893.00€100mg1,243.00€200mg1,693.00€1mL*10mM (DMSO)227.00€KDM5-IN-1
CAS:KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formula:C17H20N6OPurity:99.50%Color and Shape:SolidMolecular weight:324.38Ref: TM-T15649
1mg60.00€5mg177.00€10mg269.00€25mg427.00€50mg610.00€100mg820.00€500mgTo inquire1mL*10mM (DMSO)130.00€JH-131e-153
CAS:JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Formula:C22H38O5Color and Shape:SolidMolecular weight:382.53Bavarostat
CAS:Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Formula:C20H27FN2O2Color and Shape:SolidMolecular weight:346.44NMS-P515
CAS:NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.Formula:C21H29N3O2Purity:98%Color and Shape:SolidMolecular weight:355.47CBP/p300-IN-17
CAS:CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).Formula:C25H28N4O3Color and Shape:SolidMolecular weight:432.51RTS-V5
CAS:RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).Formula:C27H35N5O6Purity:98%Color and Shape:SolidMolecular weight:525.6TCS HDAC6 20b
CAS:TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.Formula:C26H44N2O4SPurity:>99.99%Color and Shape:SolidMolecular weight:480.7Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formula:C22H13Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:406.26Luteolin 7-sulfate
CAS:Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.Formula:C15H10O9SPurity:98%Color and Shape:SolidMolecular weight:366.3Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39Ref: TM-T78207
1mg50.00€5mg104.00€10mg167.00€25mg340.00€50mg505.00€100mg712.00€200mg1,009.00€1mL*10mM (DMSO)114.00€FHT-1015
CAS:FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).Formula:C25H25N5O4S3Purity:98.57%Color and Shape:SolidMolecular weight:555.69Ref: TM-T63925
1mg54.00€5mg114.00€10mg178.00€25mg356.00€50mg580.00€100mg888.00€1mL*10mM (DMSO)138.00€JWG-071
CAS:JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formula:C34H44N8O3Purity:99.83%Color and Shape:SolidMolecular weight:612.77EPZ031686
CAS:EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
Formula:C26H34ClF3N4O4SPurity:99.67%Color and Shape:SolidMolecular weight:591.09E7016
CAS:E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
Formula:C20H19N3O3Purity:99.02%Color and Shape:SolidMolecular weight:349.38CPI-0610 carboxylic acid
CAS:CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.Formula:C20H15ClN2O3Purity:98.62%Color and Shape:SolidMolecular weight:366.8Piflufolastat
CAS:Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA.Formula:C18H23FN4O8Purity:99.95%Color and Shape:SolidMolecular weight:442.4Ref: TM-T31224
1mg54.00€5mg114.00€10mg178.00€25mg409.00€50mg708.00€100mg1,224.00€1mL*10mM (DMSO)138.00€CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formula:C23H25ClN8OSPurity:98.14%Color and Shape:SolidMolecular weight:497.02AU-15330
CAS:AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. Cost-effective and quality-assured.Formula:C39H49N9O5SPurity:98.21% - 99.62%Color and Shape:SolidMolecular weight:755.93HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
Formula:C15H15N5O2SPurity:95.04%Color and Shape:SolidMolecular weight:329.38JAK-IN-3
CAS:JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Formula:C18H20N4O3Purity:98.04% - 98.19%Color and Shape:SolidMolecular weight:340.38Ref: TM-T11704
1mg126.00€2mg178.00€5mg304.00€10mg492.00€25mg982.00€50mg1,558.00€100mg2,538.00€200mg3,402.00€1mL*10mM (DMSO)334.00€LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purity:99.68%Color and Shape:SolidMolecular weight:489.95KDM4-IN-4
CAS:KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.Formula:C16H23NOPurity:99.61%Color and Shape:SolidMolecular weight:245.36hRIO2 kinase ligand-1
CAS:hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).Formula:C17H14N2OPurity:99.89%Color and Shape:SolidMolecular weight:262.31NPAS3-IN-1
CAS:NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.Formula:C10H5N3O2S3Purity:99.56%Color and Shape:SolidMolecular weight:295.36PARP-1-IN-4
CAS:PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.Formula:C22H15Cl2N3O2Purity:99.82%Color and Shape:SolidMolecular weight:424.28Y06137
CAS:Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.Formula:C27H32N4O2Purity:99.85%Color and Shape:SolidMolecular weight:444.57CeMMEC1
CAS:CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formula:C19H16N2O4Purity:98.9% - 99.92%Color and Shape:SolidMolecular weight:336.34PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formula:C25H37FN8O2Purity:98% - 98.79%Color and Shape:SolidMolecular weight:500.61BET-IN-8
BET-IN-8 (Compound 27) is a potent inhibitor of BET (Ki: 0.83 μM, Kd: 0.571 μM), which ameliorates LPS-induced sepsis in vivo.BET-IN-8 has shown potential inFormula:C22H21N3O4SColor and Shape:SolidMolecular weight:423.48(Rac)-RG108
CAS:(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.326TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formula:C18H16ClN5Color and Shape:SolidMolecular weight:337.81TDI-015051
CAS:TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formula:C22H22FN5O4SColor and Shape:SolidMolecular weight:471.505Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formula:C29H33ClN4O3SColor and Shape:SolidMolecular weight:553.12PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formula:C32H42N4O4Color and Shape:SolidMolecular weight:546.70(3S,4R)-Tofacitinib
CAS:(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54CCW 28-3
CAS:CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activityFormula:C44H42Cl2N6O4SColor and Shape:SolidMolecular weight:821.81PAD-IN-2
CAS:PAD-IN-2, potent PAD4 inhibitor, IC50 <1 μM; targets autoimmune/cancer disorders.Formula:C27H28ClN5O2Color and Shape:SolidMolecular weight:490PARP7-IN-23
CAS:PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.
Formula:C27H22F7N5O3Color and Shape:SolidMolecular weight:597.484GNE-886
CAS:GNE-886 has a wide range of applications in life science related research.Formula:C28H30N6O3Purity:98%Color and Shape:SolidMolecular weight:498.59LSD1-IN-13 hydrochloride
CAS:LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.Formula:C23H30ClN3O2SColor and Shape:SolidMolecular weight:448.02WW437
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo.Formula:C23H27N5O4Color and Shape:SolidMolecular weight:437.49ROPA
CAS:ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.Formula:C28H32O6Purity:98%Color and Shape:SolidMolecular weight:464.55MC2652
MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.Formula:C22H20N2OColor and Shape:SolidMolecular weight:328.41HIF-2α-IN-7
CAS:HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26BET-IN-6
CAS:BET-IN-6: Potent BRD2/4 inhibitor and ligand for PROTAC BRD2/BRD4 degrader-1 synthesis.Formula:C22H20N2O6SPurity:98%Color and Shape:SolidMolecular weight:440.47PF-06263276
CAS:PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).Formula:C31H31FN8O2Purity:98%Color and Shape:SolidMolecular weight:566.63Azaphilone-9
CAS:AZA-9 inhibits cancer growth by blocking HuR-ARE RNA binding; IC50=1.2μM.Formula:C21H23BrO5Color and Shape:SolidMolecular weight:435.31PARP-1/HDAC-IN-1
CAS:PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formula:C22H18N4O4Purity:95.94%Color and Shape:SolidMolecular weight:402.415:0 PG sodium
CAS:15:0 PG sodium serves as an activator for the Protein Kinase C family and is an anionic phospholipid located in the membranes of mitochondria and microsomes. It plays a crucial role in the composition of pulmonary surfactants, especially within the membrane of the pulmonary lamellar bodies.Formula:C36H70NaO10PColor and Shape:SolidMolecular weight:716.90JAK3-IN-7
CAS:JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFormula:C17H20N6OPurity:98.81%Color and Shape:SolidMolecular weight:324.38(1-Nitroethene-1,2-diyl)dibenzene
CAS:(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formula:C14H11NO2Color and Shape:SolidMolecular weight:225.24CM-414
CAS:CM-414: HDAC/PDE5 inhibitor, targeting Alzheimer’s, IC50s: PDE5 (60 nM), HDAC1/2/3/6. Reduces Aβ, pTau in mice, boosts cognition.Formula:C23H29N5O4Purity:98%Color and Shape:SolidMolecular weight:439.51KH-259
KH-259: potent, selective CNS-penetrant HDAC6 inhibitor with 0.26 μM IC50; shows antidepressant effects in mice.Formula:C20H25N3O2Color and Shape:SolidMolecular weight:339.43RL5a
CAS:RL5a (compound C23) is a novel inhibitor of SETD8.Formula:C17H19N3OColor and Shape:SolidMolecular weight:281.35SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Formula:C20H20N6O5SColor and Shape:SolidMolecular weight:456.48DS-9300
CAS:DS-9300, an orally administered potent and selective inhibitor of EP300/CBP HAT, exhibits a significant inhibitory activity with an IC50 value of 28 nM.Formula:C25H26F3N5O3Color and Shape:SolidMolecular weight:501.50GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purity:98%Color and Shape:SolidMolecular weight:475.92SMARCA2-IN-6
CAS:SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.Formula:C10H8ClF2N5OSColor and Shape:SolidMolecular weight:319.72
