Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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Ruboxistaurin mesylate
CAS:<p>Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.</p>Formula:C29H32N4O6SPurity:98%Color and Shape:SolidMolecular weight:564.65TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Formula:C28H34N4O2Purity:97.85%Color and Shape:SolidMolecular weight:458.6LLY-507
CAS:<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Formula:C36H42N6OPurity:99.58% - 99.93%Color and Shape:SolidMolecular weight:574.76Picolinamide
CAS:<p>Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.</p>Formula:C6H6N2OPurity:99.6%Color and Shape:SolidMolecular weight:122.12UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formula:C33H43N7O2Purity:99.19% - >99.99%Color and Shape:SolidMolecular weight:569.74AT-9283 HCl
CAS:<p>AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.</p>Formula:C19H24ClN7O2Color and Shape:SolidMolecular weight:417.89KDM4D-IN-1
CAS:<p>KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).</p>Formula:C11H7N5OPurity:99.51% - >99.99%Color and Shape:SolidMolecular weight:225.21JMJD7-IN-1
CAS:<p>JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.</p>Formula:C16H8Cl2N2O4Purity:99.66%Color and Shape:SolidMolecular weight:363.15Naphthol AS-E
CAS:<p>Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.</p>Formula:C17H12ClNO2Purity:99.33%Color and Shape:Grey Solid PowderMolecular weight:297.748-CHLOROQUINAZOLIN-4(1H)-ONE
CAS:<p>8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)</p>Formula:C8H5ClN2OPurity:98.79%Color and Shape:SolidMolecular weight:180.59ICG001
CAS:<p>ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.</p>Formula:C33H32N4O4Purity:99.06% - 99.95%Color and Shape:SolidMolecular weight:548.63(R)-(-)-JQ1 Enantiomer
CAS:<p>(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)</p>Formula:C23H25ClN4O2SPurity:99.38%Color and Shape:SolidMolecular weight:456.99AZ9482
CAS:<p>AZ9482, a potent PARP inhibitor with 2-piperazinyl-3-cyano-pyridine linkage, causes centrosome declustering in HeLa cells with an EC50 < 18 nM.</p>Formula:C26H22N6O2Purity:99.18% - 99.86%Color and Shape:SolidMolecular weight:450.49JQEZ5
CAS:<p>JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).</p>Formula:C30H38N8O2Purity:98.14% - ≥98%Color and Shape:SolidMolecular weight:542.68Rucaparib hydrochloride
CAS:<p>Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.</p>Formula:C19H19ClFN3OColor and Shape:SolidMolecular weight:359.83XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Formula:C26H30N6O3Purity:98.21%Color and Shape:SolidMolecular weight:474.55Rucaparib acetate
CAS:<p>Rucaparib acetate, an oral PARP-1, -2, -3 inhibitor (Ki 1.4 nM for PARP1), also moderately inhibits H6PD; promising for CRPC research.</p>Formula:C21H22FN3O3Color and Shape:SolidMolecular weight:383.423IOX1
CAS:<p>IOX1, a broad-spectrum 2OG oxygenase inhibitor, IC50: KDM4A - 0.6uM, KDM3A - 0.1uM.</p>Formula:C10H7NO3Purity:99.67%Color and Shape:SolidMolecular weight:189.17Menin-MLL inhibitor 20
CAS:<p>Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.</p>Formula:C33H40N8O4Purity:97.77%Color and Shape:SolidMolecular weight:612.72γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Formula:C40H58O4Purity:mixture - mixtureColor and Shape:White Or White Crystalline Powder OdourlessMolecular weight:602.9Ethyl 3,4-dihydroxybenzoate
CAS:<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.17Ruboxistaurin
CAS:<p>Ruboxistaurin (LY333531) is a selective PKC beta inhibitor, Ki 2 nM, inhibits beta I/II (IC50: 4.7/5.9 nM), orally active.</p>Formula:C28H28N4O3Color and Shape:SolidMolecular weight:468.552,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Formula:C16H13Cl2N3O2Purity:98.77%Color and Shape:SolidMolecular weight:350.2EB-47 dihydrochloride
CAS:<p>EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM).</p>Formula:C24H29Cl2N9O6Color and Shape:SolidMolecular weight:610.45SC-43
CAS:<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8WM-8014
CAS:<p>WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.</p>Formula:C20H17FN2O3SPurity:99.64%Color and Shape:SolidMolecular weight:384.42MS31 trihydrochloride
<p>MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.</p>Formula:C20H30Cl3N3O2Color and Shape:SolidMolecular weight:450.83Ro 31-8220
CAS:<p>Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.</p>Formula:C25H23N5O2SColor and Shape:SolidMolecular weight:457.55Remodelin hydrobromide
CAS:<p>Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.</p>Formula:C15H15BrN4SPurity:97.22% - 99.84%Color and Shape:SolidMolecular weight:363.275BAY-598
CAS:<p>BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.</p>Formula:C22H20Cl2F2N6O3Purity:99.18% - 99.78%Color and Shape:SolidMolecular weight:525.346-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS:<p>CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).</p>Formula:C9H9BrN2OPurity:99.28%Color and Shape:SolidMolecular weight:241.08Izilendustat hydrochloride
CAS:<p>Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.</p>Formula:C22H29Cl2N3O4Color and Shape:SolidMolecular weight:470.39Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18PF-9366
CAS:<p>PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).</p>Formula:C20H19ClN4Purity:97.28% - 99.88%Color and Shape:SolidMolecular weight:350.84Abrocitinib
CAS:<p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Formula:C18H15ClN6OS2Purity:98%Color and Shape:SolidMolecular weight:430.93PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Formula:C22H25N7O2Purity:97.58% - 99.94%Color and Shape:SolidMolecular weight:419.48Peficitinib
CAS:<p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Formula:C18H15N5OPurity:97.03%Color and Shape:SolidMolecular weight:317.34653-47
CAS:<p>653-47 enhances the effects of 666-15 on inhibiting CREB and is a mild CREB inhibitor itself (IC50: 26.3μM).</p>Formula:C20H19ClN2O3Color and Shape:SolidMolecular weight:370.83WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Formula:C16H13Br2N3O3Purity:99.93%Color and Shape:SolidMolecular weight:455.1Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Formula:C18H16FN3OPurity:97.1% - 98.74%Color and Shape:SolidMolecular weight:309.34GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formula:C18H15N3O2Purity:99.52%Color and Shape:SolidMolecular weight:305.33XAV-939
CAS:<p>XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).</p>Formula:C14H11F3N2OSPurity:97.47% - 99.67%Color and Shape:SolidMolecular weight:312.311,5-Isoquinolinediol
CAS:<p>1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.</p>Formula:C9H7NO2Purity:98.29% - 99.35%Color and Shape:Of White To White PowderMolecular weight:161.16MS7972
CAS:<p>MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM</p>Formula:C14H13NO2Purity:99.78%Color and Shape:SolidMolecular weight:227.26Molibresib
CAS:<p>Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).</p>Formula:C22H22ClN5O2Purity:97.70% - 99.08%Color and Shape:SolidMolecular weight:423.9dCBP-1
CAS:<p>dCBP-1 selectively degrades p300/CBP via CRBN, killing multiple myeloma cells.</p>Formula:C51H63F2N11O10Purity:98.21% - 99.12%Color and Shape:SolidMolecular weight:1028.11GSK 690 Hydrochloride
CAS:<p>GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.</p>Formula:C24H24ClN3OPurity:98%Color and Shape:SolidMolecular weight:405.92
