Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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KR-39038
CAS:<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Formula:C24H32ClFN6OColor and Shape:SolidMolecular weight:475.00BChE/HDAC6-IN-2
CAS:<p>BChE/HDAC6-IN-2 is an inhibitor of BChE and HDAC6 with neuroprotective and ROS scavenging activity and a metal ion co-agonist and inhibits tau phosphorylation.</p>Formula:C27H30N4O4Purity:98.47%Color and Shape:SoildMolecular weight:474.55BG48
CAS:<p>BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.</p>Formula:C25H23N5OSColor and Shape:SolidMolecular weight:441.55(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37Asteltoxin
CAS:<p>Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.</p>Formula:C23H30O7Color and Shape:SolidMolecular weight:418.486HDAC2-IN-2
CAS:<p>HDAC2-IN-2 (compound 124) acts as an HDAC2 inhibitor, exhibiting a Kd value ranging from 0.1-1 μM.</p>Formula:C18H15N3O3SColor and Shape:SolidMolecular weight:353.40E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46TMPA
CAS:<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Formula:C21H32O6Purity:99.21%Color and Shape:SolidMolecular weight:380.48GSK-1268997
CAS:<p>GSK-1268997 is a bio-active chemical.</p>Formula:C21H23N7O3SPurity:99.33% - 99.81%Color and Shape:SolidMolecular weight:453.52UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67MY-1B
CAS:<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Formula:C22H18BrN3O2Purity:99.81% - >99.99%Color and Shape:SoildMolecular weight:436.3JAK-IN-30
CAS:<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Formula:C19H26N8SPurity:98%Color and Shape:SolidMolecular weight:398.53ZYJ-34c
CAS:<p>ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).</p>Formula:C31H42N4O7Purity:98%Color and Shape:SolidMolecular weight:582.69SIRT1-IN-3
CAS:<p>SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].</p>Formula:C13H15BrN2OColor and Shape:SolidMolecular weight:295.17Eleven-Nineteen-Leukemia Protein IN-1
CAS:<p>ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.</p>Formula:C27H33N7O2Purity:98%Color and Shape:SolidMolecular weight:487.6Angiogenesis agent 1
CAS:<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4LSD1-IN-5
CAS:<p>LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.</p>Formula:C15H13BrN2O3Purity:98%Color and Shape:SolidMolecular weight:349.18EZH2-IN-7
CAS:<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Formula:C31H37D2N5O3SColor and Shape:SolidMolecular weight:563.75CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Formula:C29H40N4O3Purity:99.23%Color and Shape:SolidMolecular weight:492.655-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Formula:C8H12N4O3SColor and Shape:SolidMolecular weight:244.27Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formula:C15H11NO3Purity:98%Color and Shape:SolidMolecular weight:253.25DC_C66
CAS:<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Formula:C28H22NO2Purity:98%Color and Shape:SolidMolecular weight:404.48Aurora kinase inhibitor-9
CAS:<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Formula:C19H17Cl2N3O4SColor and Shape:SolidMolecular weight:454.33G9a-IN-2
CAS:<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Formula:C30H42N4O4Color and Shape:SolidMolecular weight:522.68HDAC1/MAO-B-IN-1
CAS:<p>HDAC1/MAO-B-IN-1 is a selective Alzheimer’s research inhibitor with IC50s: HDAC1 (21.4 nM) & MAO-B (99 nM); crosses the blood-brain barrier.</p>Formula:C18H17ClN2O2Color and Shape:SolidMolecular weight:328.79Tankyrase-IN-4
<p>Tankyrase-IN-4 is a potent inhibitor of tankyrase 1 (TNKS1), exhibiting an IC50 of 0.8 nM, and is utilized in cancer research.</p>Formula:C25H24N6O5Color and Shape:SolidMolecular weight:488.5LP99
CAS:<p>LP99 is an epigenetic probe.</p>Formula:C26H30ClN3O4SPurity:99.74%Color and Shape:SolidMolecular weight:516.05TM6089
CAS:<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Formula:C13H14N4O3SPurity:99.70%Color and Shape:SolidMolecular weight:306.34FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Formula:C23H24ClN7O3Color and Shape:SolidMolecular weight:481.93BET bromodomain inhibitor 3
CAS:<p>BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.</p>Formula:C18H17N3O4Purity:98%Color and Shape:SolidMolecular weight:339.35PRMT4-IN-1
CAS:<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Formula:C23H28FN3OPurity:98%Color and Shape:SolidMolecular weight:381.49PARP11 inhibitor ITK7
CAS:<p>ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.</p>Formula:C17H14N4OSColor and Shape:SolidMolecular weight:322.38HDAC-IN-41
CAS:<p>HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.</p>Formula:C20H22N4O6SColor and Shape:SolidMolecular weight:446.48BI-831266
CAS:<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Formula:C27H38ClN7O2Color and Shape:SolidMolecular weight:528.09KF 13218
CAS:<p>KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.</p>Formula:C20H20N2O3Purity:98%Color and Shape:SolidMolecular weight:336.38YUKA1
CAS:<p>YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.</p>Formula:C13H16N4O2SPurity:99.85%Color and Shape:SolidMolecular weight:292.36HDAC-IN-30
CAS:<p>HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.</p>Formula:C22H23N5O3Color and Shape:SolidMolecular weight:405.45HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Formula:C24H30FN3O4Color and Shape:SolidMolecular weight:443.51JFD00244
CAS:<p>JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.</p>Formula:C30H26N2O4Purity:98%Color and Shape:SolidMolecular weight:478.54Y06036
CAS:<p>Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).</p>Formula:C16H15BrN2O5SPurity:99.97%Color and Shape:SolidMolecular weight:427.27PRMT5-IN-2
CAS:<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Formula:C17H16ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:394.78NCD38
CAS:<p>NCD38 is a potent, selective LSD1 inhibitor.</p>Formula:C37H37ClF3N3O4Purity:98.21% - 98.86%Color and Shape:SolidMolecular weight:680.16(Rac)-BAY1238097
CAS:<p>(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.</p>Formula:C25H33N5O3Purity:98%Color and Shape:SolidMolecular weight:451.56JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formula:C19H19ClN2OSColor and Shape:SolidMolecular weight:358.89EZM 2302
CAS:<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Formula:C29H37ClN6O5Purity:97.47% - ≥98%Color and Shape:SolidMolecular weight:585.09HDAC6-IN-11
CAS:<p>HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.</p>Formula:C19H16N2O4Color and Shape:SolidMolecular weight:336.34HDAC8/BRPF1-IN-1
CAS:<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Formula:C19H19N3O6SColor and Shape:SolidMolecular weight:417.44OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Formula:C24H42N6O5Color and Shape:SolidMolecular weight:494.63J1038
CAS:<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Formula:C10H10N2O3SColor and Shape:SolidMolecular weight:238.26A2B57
CAS:<p>A2B57 is a selective SIRT2 inhibitor.</p>Formula:C22H19N5OPurity:98%Color and Shape:SolidMolecular weight:369.42
