Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2613 products of "Chromatin/Epigenetics"
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BChE/HDAC6-IN-1
CAS:BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.Formula:C34H43N5O5Purity:98%Color and Shape:SolidMolecular weight:601.74CLB-016
CAS:CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.Formula:C17H20N6O3Purity:98%Color and Shape:SolidMolecular weight:356.38SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02Nezulcitinib
CAS:Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formula:C30H37N7O2Color and Shape:SolidMolecular weight:527.66AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Formula:C23H22F3N3O5Color and Shape:SolidMolecular weight:477.43CBP/p300-IN-19 hydrochloride
CAS:CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.Formula:C30H28ClN3O3Color and Shape:SolidMolecular weight:514.02KDM5-IN-1
CAS:KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formula:C17H20N6OPurity:99.50%Color and Shape:SolidMolecular weight:324.38Ref: TM-T15649
500mgTo inquire1mg60.00€1mL*10mM (DMSO)130.00€5mg177.00€10mg269.00€25mg427.00€50mg610.00€100mg820.00€CBB1007 hydrochloride
CAS:CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.Formula:C27H39Cl5N8O4Color and Shape:SoildMolecular weight:716.91MS67
CAS:MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formula:C52H59F4N9O7SColor and Shape:SolidMolecular weight:1030.14RK-701
CAS:RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Formula:C26H30N4O3Color and Shape:SolidMolecular weight:446.54HA-1004 dihydrochloride
CAS:HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel proteinFormula:C12H16ClN5O2SPurity:98%Color and Shape:White Crystalline SolidMolecular weight:329.81ZINC08792229
CAS:ZINC08792229 is a novel inhibitor of SIRT1.Formula:C30H22N4O3Purity:98%Color and Shape:SolidMolecular weight:486.52L-Moses
CAS:L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Formula:C21H24N6Purity:98%Color and Shape:SolidMolecular weight:360.46KH-3
CAS:KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.Formula:C21H22N2O4S2Color and Shape:SolidMolecular weight:430.54I-BET762 carboxylic acid
CAS:I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).Formula:C20H17ClN4O3Purity:98%Color and Shape:SolidMolecular weight:396.83PARPYnD
CAS:PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.Formula:C34H31N9O3Color and Shape:SolidMolecular weight:613.67CBB1007
CAS:CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H34N8O4Purity:98%Color and Shape:SolidMolecular weight:534.61Luteolin 7-sulfate
CAS:Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.Formula:C15H10O9SPurity:98%Color and Shape:SolidMolecular weight:366.3JAK-IN-25
CAS:JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37PIN1 inhibitor 2
CAS:PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.Formula:C16H21N3S2Color and Shape:SolidMolecular weight:319.49RTS-V5
CAS:RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).Formula:C27H35N5O6Purity:98%Color and Shape:SolidMolecular weight:525.6ZINC08792355
CAS:ZINC08792355 is a novel inhibitor of SIRT1.Formula:C31H24N4O3Color and Shape:SolidMolecular weight:500.55SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurity:98%Color and Shape:SolidMolecular weight:673.73TNKS1/2-IN-1
CAS:TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Formula:C26H23F4N3O4Color and Shape:SolidMolecular weight:517.47ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Formula:C13H13BrN2OSPurity:99.751%Color and Shape:SolidMolecular weight:325.22Ref: TM-T13411
1mg93.00€5mg177.00€1mL*10mM (DMSO)178.00€10mg269.00€25mg429.00€50mg610.00€100mg820.00€200mg1,071.00€BATCP
CAS:BATCP is an inhibitor of histone deacetylases (HDAC) [1].Formula:C23H28F3N3O6Color and Shape:SolidMolecular weight:499.487NHWD-870
CAS:NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.Formula:C29H29N7OPurity:98%Color and Shape:SolidMolecular weight:491.59CBP/p300-IN-17
CAS:CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).Formula:C25H28N4O3Color and Shape:SolidMolecular weight:432.51(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formula:C17H23N3O2Purity:98%Color and Shape:SolidMolecular weight:301.38(Iso)-MS4322
CAS:(Iso)-MS4322 ((Iso)-YS43-22) is a protein arginine methyltransferase 5 (PRMT5 ) degrader with potential anticancer activity.Formula:C55H76N10O12SPurity:99.05% - 99.79%Color and Shape:SolidMolecular weight:1101.32CM-675
CAS:CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential toFormula:C31H32N6O3Purity:99.82%Color and Shape:SolidMolecular weight:536.62Ref: TM-T10841
1mg60.00€2mg90.00€5mg138.00€1mL*10mM (DMSO)152.00€10mg215.00€25mg358.00€50mg510.00€100mg692.00€CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54Prolyl Hydroxylase inhibitor 1
CAS:Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).Formula:C19H18ClN5O4Purity:98%Color and Shape:SolidMolecular weight:415.83CBP/p300-IN-19
CAS:CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.Formula:C30H27N3O3Color and Shape:SolidMolecular weight:477.55PARP7-probe-1
CAS:PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.Formula:C36H49F3N8O5SColor and Shape:SolidMolecular weight:762.89FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formula:C21H20F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:430.47MS023 trihydrochloride
CAS:MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formula:C17H28Cl3N3OPurity:99.81%Color and Shape:SolidMolecular weight:396.78PRMT5-IN-16
CAS:PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Formula:C25H34N8O2Color and Shape:SolidMolecular weight:478.59Oxamflatin
CAS:Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).Formula:C17H14N2O4SPurity:98.25%Color and Shape:SolidMolecular weight:342.37Ref: TM-T16415
1mg58.00€1mL*10mM (DMSO)114.00€5mg145.00€10mg215.00€25mg477.00€50mg670.00€100mg879.00€200mg1,161.00€ZL0420
CAS:ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.Formula:C16H16N4O2Purity:99.38%Color and Shape:SolidMolecular weight:296.32GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formula:C19H32N8O5Color and Shape:SolidMolecular weight:452.511,2-Didecanoyl-sn-glycerol
CAS:GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Formula:C23H44O5Color and Shape:SolidMolecular weight:400.6PRT543
CAS:PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formula:C17H17ClN4O4Color and Shape:SolidMolecular weight:376.79BRCA1-IN-2
CAS:BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.Formula:C26H33N4O7PPurity:98.04%Color and Shape:SolidMolecular weight:544.54Lin281632
CAS:Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Formula:C15H15N5OPurity:99.84%Color and Shape:SolidMolecular weight:281.31Ref: TM-T27835
1mg34.00€5mg71.00€1mL*10mM (DMSO)79.00€10mg101.00€25mg212.00€50mg340.00€100mg535.00€500mg1,144.00€OM-1700
CAS:OM-1700 inhibits tankyrase 1 (IC50=127 nM) and 2 (IC50=14 nM); hinders colon cancer cell growth, COLO 320DM (GI50=650 nM).Formula:C25H23FN6O2Color and Shape:SolidMolecular weight:458.49JAK-IN-24
CAS:JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formula:C20H25N5O2Color and Shape:SolidMolecular weight:367.44NSC756093
CAS:NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.Formula:C20H19NO4Purity:99.92%Color and Shape:SolidMolecular weight:337.37Ref: TM-T24557
1mg47.00€5mg92.00€1mL*10mM (DMSO)117.00€10mg157.00€25mg329.00€50mg490.00€100mg700.00€500mg1,406.00€JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formula:C33H38F2N6O8Color and Shape:SolidMolecular weight:684.69TCJL37
CAS:TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formula:C17H11ClF2N4O2Color and Shape:SolidMolecular weight:376.74
