Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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Bromodomain IN-2
CAS:<p>BD-IN-1: Bromodomain inhibitor, K D 67-970nM for BRD4, CBP, etc. Antiproliferative.</p>Formula:C16H17ClN2OColor and Shape:SolidMolecular weight:288.77Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Formula:C737H972F20N211O349P43S8Color and Shape:SolidMolecular weight:20339.13Lys-CoA TFA
<p>Lys-CoA TFA: p300 HAT inhibitor, IC50 50-500 nM, >100x selective vs PCAF, inhibits p300-dependent transcription.</p>Formula:C33H54F3N10O21P3SColor and Shape:SolidMolecular weight:1108.82C8 Dihydroceramide
CAS:<p>C8 Dihydroceramide is a control for C8 Ceramide, a bioactive, cell-permeable, chemotherapeutic agent that boosts T cell responses and slightly activates PKC.</p>Formula:C26H53NO3Color and Shape:SolidMolecular weight:427.70HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Color and Shape:Odour SolidTDI-012804
<p>TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.</p>Color and Shape:Odour SolidProtein Kinase C (19-36)
CAS:<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Formula:C93H159N35O24Purity:98%Color and Shape:SolidMolecular weight:2151.48PIM-IN-1
CAS:<p>PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).</p>Formula:C15H18ClFN4OColor and Shape:SolidMolecular weight:324.78Protein kinase C α peptide TFA
CAS:<p>Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.</p>Formula:C68H115F3N24O26SColor and Shape:SolidMolecular weight:1773.85JAK1/TYK2-IN-1
CAS:<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Formula:C18H20F3N7OColor and Shape:SolidMolecular weight:407.401PROTAC BRD4 Degrader-1
CAS:<p>PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).</p>Formula:C40H37N9O8Purity:98%Color and Shape:SolidMolecular weight:771.78FTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formula:C22H19ClFN5O2Color and Shape:SolidMolecular weight:439.87PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Formula:C43H41FN8O5Color and Shape:SolidMolecular weight:768.85UNC6349 (Ket2)
<p>UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].</p>Formula:C41H57N7O11Color and Shape:SolidMolecular weight:823.93SMARCA2 degrader-17
CAS:<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Formula:C47H58N10O6SColor and Shape:SolidMolecular weight:891.09C 21
CAS:<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Formula:C90H161ClN36O24Purity:98%Color and Shape:SolidMolecular weight:2166.94SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purity:98%Color and Shape:SolidMolecular weight:3432.05HDAC8-IN-6
<p>HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.</p>Formula:C19H18IN3O2Molecular weight:447.04437GXH-II-052
<p>GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.</p>Formula:C62H76Cl2F2N14O11S2Color and Shape:SolidMolecular weight:1366.39RBN012811
CAS:<p>RBN012811 is a PROTAC specifically targeting PARP14.</p>Formula:C40H49FN8O6SColor and Shape:SolidMolecular weight:788.93
