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Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.

Subcategories of "Chromatin/Epigenetics"

Found 2437 products of "Chromatin/Epigenetics"

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  • CymitQuimica logo
    Targetmol
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    GW814408X

    CAS:
    GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].
    Formula:C19H16N6O
    Molecular weight:344.37

    Ref: TM-T86538

  • (S)-Ro 32-0432
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    (S)-Ro 32-0432

    CAS:
    (S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].
    Formula:C28H29ClN4O2
    Color and Shape:Solid
    Molecular weight:489.01

    Ref: TM-T84742

  • QC6352
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    QC6352

    CAS:
    QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
    Formula:C24H25N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.47

    Ref: TM-T16700

  • HDAC6/HSP90-IN-1
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    HDAC6/HSP90-IN-1

    CAS:
    HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.
    Formula:C28H37N3O6
    Color and Shape:Solid
    Molecular weight:511.61

    Ref: TM-T63531

  • GNE-049
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    GNE-049

    CAS:
    GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.
    Formula:C27H32F2N6O2
    Purity:98.67%
    Color and Shape:Solid
    Molecular weight:510.58

    Ref: TM-T15397

  • PIM1-IN-1
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    PIM1-IN-1

    CAS:
    PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.
    Formula:C25H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.56

    Ref: TM-T12474

  • 1,2-Didecanoyl-sn-glycerol
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    1,2-Didecanoyl-sn-glycerol

    CAS:
    GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.
    Formula:C23H44O5
    Color and Shape:Solid
    Molecular weight:400.6

    Ref: TM-T84614

  • GSK-2807 free base
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    GSK-2807 free base

    CAS:
    GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.
    Formula:C19H32N8O5
    Color and Shape:Solid
    Molecular weight:452.51

    Ref: TM-T69738

  • JAK-IN-4
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    JAK-IN-4

    CAS:
    JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.
    Formula:C18H21N4Na2O6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:466.341

    Ref: TM-T11705

  • Vafidemstat
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    Vafidemstat

    CAS:
    Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.
    Formula:C19H20N4O2
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:336.39

    Ref: TM-T17211

  • CD235
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    CD235

    CAS:
    CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.
    Formula:C26H20FN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:453.47

    Ref: TM-T10720

  • CM-579 trihydrochloride (1846570-40-8 free base)
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    CM-579 trihydrochloride (1846570-40-8 free base)

    CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide
    Formula:C29H43Cl3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.04

    Ref: TM-T10840

  • YM-08
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    YM-08

    CAS:
    YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].
    Formula:C19H17N3OS2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:367.49

    Ref: TM-T80752

  • MAK683-CH2CH2COOH
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    MAK683-CH2CH2COOH

    CAS:
    MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.
    Formula:C23H21FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.45

    Ref: TM-T13765

  • (1s,4s)-Menin-MLL inhibitor-23
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    (1s,4s)-Menin-MLL inhibitor-23

    <p>(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].</p>
    Formula:C36H53FN6O4
    Color and Shape:Solid
    Molecular weight:652.84

    Ref: TM-T72135

  • PHD2/HDACs-IN-1
    Targetmol
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    PHD2/HDACs-IN-1

    CAS:
    PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.
    Formula:C18H19N9O4
    Color and Shape:Solid
    Molecular weight:425.4

    Ref: TM-T62298

  • BRD-IN-3
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    BRD-IN-3

    CAS:
    BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.
    Formula:C21H25N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T10604

  • GSK-3484862
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    GSK-3484862

    CAS:
    Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.
    Formula:C19H19N5OS
    Purity:99.87% - 99.963%
    Color and Shape:Solid
    Molecular weight:365.45

    Ref: TM-T11469

  • SMYD3-IN-1
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    SMYD3-IN-1

    CAS:
    SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
    Formula:C28H31ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:507.02

    Ref: TM-T12940

  • TCS HDAC6 20b
    Targetmol
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    TCS HDAC6 20b

    CAS:
    TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.
    Formula:C26H44N2O4S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:480.7

    Ref: TM-T22159