DNA-PK
DNA-PK (DNA-dependent protein kinase) is a key enzyme involved in the repair of DNA double-strand breaks through the non-homologous end joining (NHEJ) pathway. DNA-PK inhibitors block the activity of this kinase, preventing the repair of DNA breaks and leading to increased cell death, particularly in cancer cells. DNA-PK inhibitors are valuable tools in cancer research and therapy, especially in combination with other DNA-damaging treatments. At CymitQuimica, we provide a comprehensive range of high-quality DNA-PK inhibitors to support your research in DNA repair, cancer biology, and therapeutic development.
Found 49 products of "DNA-PK"
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KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Formula:C25H19NO3SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:413.49Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Formula:C18H17N5O3Purity:98.25% - ≥95%Color and Shape:SolidMolecular weight:351.36Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29Ref: TM-T7014
1mg35.00€2mg50.00€5mg74.00€1mL*10mM (DMSO)74.00€10mg117.00€25mg226.00€50mg364.00€100mg532.00€Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formula:C23H26N4O3Purity:98.41% - 99.69%Color and Shape:SolidMolecular weight:406.48PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64PIK-75
CAS:PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28NU-7163
CAS:NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.Formula:C18H17NO3Purity:98%Color and Shape:SolidMolecular weight:295.33DNA-PK-IN-3
CAS:DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.Formula:C19H19N9OColor and Shape:SolidMolecular weight:389.41DNA-PK-IN-1
CAS:DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.Formula:C23H26N8O2Color and Shape:SolidMolecular weight:446.5DNA-PK-IN-5
CAS:DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.Formula:C21H22N8O2Color and Shape:SolidMolecular weight:418.45DNA-PK-IN-7
CAS:DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).Formula:C19H21N9O2Color and Shape:SolidMolecular weight:407.43DNA-PK-IN-4
CAS:DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.Formula:C20H24N6O3Color and Shape:SolidMolecular weight:396.44(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Formula:C16H21NO3Purity:99.54%Color and Shape:SolidMolecular weight:275.34DNA-PK-IN-10
CAS:DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].Formula:C25H28N6O2Purity:98%Color and Shape:SolidMolecular weight:444.53SU-11752
CAS:SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.Formula:C26H27N3O5SColor and Shape:SolidMolecular weight:493.57ZL-2201
CAS:ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.Formula:C20H25N9O5SPurity:98%Color and Shape:SolidMolecular weight:503.54
