DNA-PK
DNA-PK (DNA-dependent protein kinase) is a key enzyme involved in the repair of DNA double-strand breaks through the non-homologous end joining (NHEJ) pathway. DNA-PK inhibitors block the activity of this kinase, preventing the repair of DNA breaks and leading to increased cell death, particularly in cancer cells. DNA-PK inhibitors are valuable tools in cancer research and therapy, especially in combination with other DNA-damaging treatments. At CymitQuimica, we provide a comprehensive range of high-quality DNA-PK inhibitors to support your research in DNA repair, cancer biology, and therapeutic development.
Found 51 products of "DNA-PK"
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Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46OSI-027
CAS:<p>OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.</p>Formula:C21H22N6O3Purity:97.42%Color and Shape:SolidMolecular weight:406.44PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purity:98.41% - 99.69%Color and Shape:SolidMolecular weight:406.48Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formula:C16H17N5O2Purity:99.14%Color and Shape:SolidMolecular weight:311.34CC-115
CAS:<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Formula:C16H16N8OPurity:86.79% - 99.01%Color and Shape:SolidMolecular weight:336.35YU238259
CAS:<p>YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.</p>Formula:C22H22ClN3O4SPurity:99.28% - 99.56%Color and Shape:SolidMolecular weight:459.95KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formula:C33H34N4O4SPurity:98.75%Color and Shape:SolidMolecular weight:582.71LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Formula:C19H17NO5SPurity:99.1% - 99.51%Color and Shape:SolidMolecular weight:371.41PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Formula:C18H17NO3Purity:98%Color and Shape:SolidMolecular weight:295.33DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Formula:C23H26N8O2Color and Shape:SolidMolecular weight:446.5DNA-PK-IN-5
CAS:<p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>Formula:C21H22N8O2Color and Shape:SolidMolecular weight:418.45DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Formula:C19H19N9OColor and Shape:SolidMolecular weight:389.41DNA-PK-IN-7
CAS:<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Formula:C19H21N9O2Color and Shape:SolidMolecular weight:407.43DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Formula:C20H24N6O3Color and Shape:SolidMolecular weight:396.44(R)-(-)-Rolipram
CAS:<p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>Formula:C16H21NO3Purity:99.54%Color and Shape:SolidMolecular weight:275.34
