Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 135 products of "Topoisomerase"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
(±)-10-Hydroxycamptothecin
CAS:(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.
Formula:C20H16N2O5Purity:98% - 99.06%Color and Shape:SolidMolecular weight:364.35PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formula:C32H35NO13Purity:98.24%Color and Shape:SolidMolecular weight:641.62Ref: TM-T16557
1mg87.00€5mg178.00€10mg326.00€25mg537.00€50mg735.00€100mg964.00€1mL*10mM (DMSO)263.00€Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formula:C20H16N2O4Purity:99.52% - 99.88%Color and Shape:Solid PowderMolecular weight:348.35Ellipticine
CAS:Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Formula:C17H14N2Purity:97.26% - 99.88%Color and Shape:SolidMolecular weight:246.31IID432
IID432 is a TopoII (topoisomerase II) inhibitor against Trypanosoma cruzi with an EC50 of 8 nM, achieving recurrence-free parasite clearance in chronic Chagas disease mouse models.Formula:C19H19N7OMolecular weight:361.4T638
CAS:T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formula:C18H16N4OSColor and Shape:SolidMolecular weight:336.41BNS-22
CAS:BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.Formula:C24H25NO5Purity:99.62%Color and Shape:SolidMolecular weight:407.46Exatecan mesylate dihydrate
CAS:Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].Formula:C25H30FN3O9SPurity:98%Color and Shape:SolidMolecular weight:567.58PluriSIn #2
CAS:PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formula:C11H8FN3O3Purity:98% - 99.79%Color and Shape:SolidMolecular weight:249.2Daniquidone
CAS:Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormula:C15H11N3OPurity:98.39% - 99.52%Color and Shape:SolidMolecular weight:249.27Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurity:99.2% - 99.34%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46Aldoxorubicin
CAS:Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Formula:C37H42N4O13Purity:98%Color and Shape:SolidMolecular weight:750.75Pyrazoloacridine
CAS:Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formula:C19H21N5O3Purity:99.72%Color and Shape:SolidMolecular weight:367.4Pegamotecan
CAS:Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormula:C52H48N6O14Purity:96.40% - 97.83%Color and Shape:SolidMolecular weight:980.984LMP744 hydrochloride
CAS:LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
Formula:C24H25ClN2O7Purity:99.59% - 99.85%Color and Shape:SolidMolecular weight:488.92SDOX
CAS:SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formula:C69H97NO20S2Purity:98%Color and Shape:SolidMolecular weight:1324.63ARN-21934
CAS:ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formula:C21H24N6Purity:99.8%Color and Shape:SolidMolecular weight:360.46Ref: TM-T36968
1mg62.00€2mg89.00€5mg135.00€10mg212.00€25mg373.00€50mg509.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)149.00€Anticancer agent 216
CAS:Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formula:C23H21N3O6Color and Shape:SolidMolecular weight:435.43Ac-Exatecan
CAS:Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.Formula:C26H24FN3O5Purity:97.09%Color and Shape:SolidMolecular weight:477.48Topoisomerase inhibitor 2
CAS:Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].Formula:C23H23N5O4Purity:98%Color and Shape:SolidMolecular weight:433.46Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormula:C23H15Br2FN2Purity:98%Color and Shape:SolidMolecular weight:498.19NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formula:C30H30F4N4O7Purity:98%Color and Shape:SolidMolecular weight:634.58Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormula:C22H18ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:428.84Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurity:98%Color and Shape:SolidMolecular weight:348.44Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Color and Shape:SolidMolecular weight:481.498Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formula:C23H22FN3O4Color and Shape:SolidMolecular weight:423.44Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Formula:C18H13ClN2O3Color and Shape:SolidMolecular weight:340.76Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purity:98.47%Color and Shape:SolidMolecular weight:447.48LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Color and Shape:SolidMolecular weight:410.4TH1338
CAS:TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.
Formula:C22H21N3O4Purity:98.77%Color and Shape:SolidMolecular weight:391.42Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formula:C20H21N3OSColor and Shape:SolidMolecular weight:351.47Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Formula:C25H28N2O4SiPurity:98%Color and Shape:SolidMolecular weight:448.59Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formula:C29H28N4O11Purity:98%Color and Shape:SolidMolecular weight:608.55Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formula:C18H10O7Color and Shape:SolidMolecular weight:338.27
