Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products of "Topoisomerase"
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Topoisomerase II inhibitor 13
CAS:<p>WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.</p>Formula:C22H23N9Purity:98.4%Color and Shape:SoildMolecular weight:413.48Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61DTS-108
CAS:<p>DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.</p>Formula:C145H233N43O33S2Color and Shape:SolidMolecular weight:3170.8Topoisomerase I inhibitor 10
<p>Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.</p>Purity:98%Color and Shape:Odour SolidAuM1Gly
<p>AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low</p>Purity:98%Color and Shape:Odour Solid(4-NH2)-Exatecan
CAS:<p>(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).</p>Formula:C23H21N3O4Purity:99.89%Color and Shape:SolidMolecular weight:403.43Daun02
CAS:<p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>Formula:C41H44N2O20Purity:98%Color and Shape:SolidMolecular weight:884.79Genz-644282
CAS:<p>Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.</p>Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.421,4-Naphthoquinone
CAS:<p>1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.</p>Formula:C10H6O2Purity:99.24% - 99.56%Color and Shape:SolidMolecular weight:158.15Berberine
CAS:<p>1.</p>Formula:C20H18NO4Purity:95.71% - 99.67%Color and Shape:SolidMolecular weight:336.36Voreloxin hydrochloride
CAS:<p>Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.</p>Formula:C18H20ClN5O4SPurity:99.84%Color and Shape:SolidMolecular weight:437.9Idarubicin hydrochloride
CAS:<p>Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).</p>Formula:C26H27NO9·HClPurity:98.91% - 99.96%Color and Shape:SolidMolecular weight:533.95Phenoxodiol
CAS:<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>Formula:C15H12O3Purity:98.07%Color and Shape:SolidMolecular weight:240.25Aurintricarboxylic acid
CAS:<p>Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.</p>Formula:C22H14O9Purity:97.1%Color and Shape:Deep Red Coarse Crystalline PowderMolecular weight:422.34
