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Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.

Found 136 products of "Topoisomerase"

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  • Indotecan
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    Indotecan

    CAS:
    <p>Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).</p>
    Formula:C26H26N2O7
    Purity:97% - 98%
    Color and Shape:Solid
    Molecular weight:478.49

    Ref: TM-T15578

  • Garenoxacin mesylate hydrate
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    Garenoxacin mesylate hydrate

    CAS:
    <p>Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains</p>
    Formula:C23H20F2N2O4·CH4O3S·H2O
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:540.53

    Ref: TM-T7804

  • Exatecan Mesylate
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    Exatecan Mesylate

    CAS:
    <p>Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).</p>
    Formula:C25H26FN3O7S
    Purity:97.32% - 99.9%
    Color and Shape:Solid
    Molecular weight:531.55

    Ref: TM-TQ0088

  • Topovale
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    Topovale

    CAS:
    <p>Topovale (ARC111) is a potent inhibitor of topoisomerase I.</p>
    Formula:C23H23N3O5
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:421.45

    Ref: TM-T9088

  • Nitidine chloride
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    Nitidine chloride

    CAS:
    1.
    Formula:C21H18ClNO4
    Purity:96.59% - 99.55%
    Color and Shape:Solid
    Molecular weight:383.82

    Ref: TM-T5S0761

  • Prulifloxacin
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    Prulifloxacin

    CAS:
    <p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>
    Formula:C21H20FN3O6S
    Purity:99.47%
    Color and Shape:Yellow Or Slightly Yellow Power
    Molecular weight:461.46

    Ref: TM-T5394

  • NU2058
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    NU2058

    CAS:
    <p>NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.</p>
    Formula:C12H17N5O
    Purity:99.34% - 99.92%
    Color and Shape:Solid
    Molecular weight:247.3

    Ref: TM-T3186

  • Rabdosiin
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    Rabdosiin

    CAS:
    <p>Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.</p>
    Formula:C36H30O16
    Purity:98.64% - 99.49%
    Color and Shape:Solid
    Molecular weight:718.61

    Ref: TM-T12651

  • 9-Methoxycamptothecin
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    9-Methoxycamptothecin

    CAS:
    9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
    Formula:C21H18N2O5
    Purity:98.49% - 99.56%
    Color and Shape:Solid
    Molecular weight:378.38

    Ref: TM-T5S1952

  • Mitoxantrone
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    Mitoxantrone

    CAS:
    <p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>
    Formula:C22H28N4O6
    Purity:96.29% - 98.74%
    Color and Shape:Blue Powder
    Molecular weight:444.48

    Ref: TM-T6588

  • β-Lapachone
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    β-Lapachone

    CAS:
    <p>β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.</p>
    Formula:C15H14O3
    Purity:99.76% - 99.88%
    Color and Shape:Solid
    Molecular weight:242.27

    Ref: TM-T6407

  • Ellipticine hydrochloride
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    Ellipticine hydrochloride

    CAS:
    <p>Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.</p>
    Formula:C17H15ClN2
    Purity:97.18%
    Color and Shape:Solid
    Molecular weight:282.76

    Ref: TM-T4614

  • Coralyne chloride
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    Coralyne chloride

    CAS:
    <p>Coralyne chloride is a protoberberine with strong anticancer activity.</p>
    Formula:C22H22ClNO4
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:399.87

    Ref: TM-T31011

  • Amsacrine hydrochloride
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    Amsacrine hydrochloride

    CAS:
    <p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>
    Formula:C21H20ClN3O3S
    Purity:99.05% - 99.92%
    Color and Shape:Solid
    Molecular weight:429.92

    Ref: TM-T5820

  • Amonafide
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    Amonafide

    CAS:
    <p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>
    Formula:C16H17N3O2
    Purity:99.39%
    Color and Shape:Solid
    Molecular weight:283.33

    Ref: TM-T6336

  • Groenlandicine
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    Groenlandicine

    CAS:
    <p>Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.</p>
    Formula:C19H16NO4
    Purity:98.59% - 99.77%
    Color and Shape:Solid
    Molecular weight:322.34

    Ref: TM-TN1037

  • Irinotecan
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    Irinotecan

    CAS:
    <p>Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.</p>
    Formula:C33H38N4O6
    Purity:98% - 99.92%
    Color and Shape:Solid
    Molecular weight:586.68

    Ref: TM-T6228

  • Dxd
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    Dxd

    CAS:
    <p>Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!</p>
    Formula:C26H24FN3O6
    Purity:98.21% - ≥98%
    Color and Shape:Solid
    Molecular weight:493.48

    Ref: TM-T11249L

  • Levofloxacin
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    Levofloxacin

    CAS:
    Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.
    Formula:C18H20FN3O4
    Purity:98.14% - 99.80%
    Color and Shape:Off-White To Yellow Crystals
    Molecular weight:361.37

    Ref: TM-T6567

  • TAS-103 dihydrochloride
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    TAS-103 dihydrochloride

    CAS:
    <p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>
    Formula:C20H21Cl2N3O2
    Purity:97.78%
    Color and Shape:Solid
    Molecular weight:406.31

    Ref: TM-T7309